Stress-impaired transcription factor expression and insulin secretion in transplanted human islets. (Q36867289)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27064285%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

title

Stress-impaired transcription factor expression and insulin secretion in transplanted human islets (English)

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1 April 2020

author

Christopher H. Emfinger

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1 April 2020

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1 April 2020

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1 April 2020

Chunhua Dai

1 reference

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1 April 2020

Nora S Kayton

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1 April 2020

Alena Shostak

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1 April 2020

Greg Poffenberger

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1 April 2020

Holly A Cyphert

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1 April 2020

Radhika Aramandla

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1 April 2020

Courtney Thompson

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1 April 2020

Ioannis G Papagiannis

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1 April 2020

Masakazu Shiota

1 reference

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1 April 2020

Dale L Greiner

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1 April 2020

Leonard D Shultz

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1 April 2020

Roland Stein

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1 April 2020

Alvin C Powers

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1 April 2020

language of work or name

English

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publication date

11 April 2016

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Journal of Clinical Investigation

1 April 2020

published in

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1 April 2020

volume

126

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1 April 2020

issue

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1 April 2020

page(s)

1857-1870

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describes a project that uses

1 April 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4855919/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

29 September 2017

1 reference

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Fatty acids induce amylin expression and secretion by pancreatic beta-cells.

29 September 2017

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Glucolipotoxicity of the pancreatic beta cell.

29 September 2017

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Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion.

29 September 2017

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Glucolipotoxicity: fuel excess and beta-cell dysfunction.

29 September 2017

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Reactive oxygen species as a signal in glucose-stimulated insulin secretion

29 September 2017

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Glucose infusion in mice: a new model to induce beta-cell replication

29 September 2017

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MafB is required for islet beta cell maturation

29 September 2017

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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

29 September 2017

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29 September 2017

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Regulation of the insulin gene by glucose and fatty acids

29 September 2017

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The unique cytoarchitecture of human pancreatic islets has implications for islet cell function

29 September 2017

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Beta-cell function, insulin sensitivity, and glucose tolerance in obese diabetic and nondiabetic adolescents and young adults

29 September 2017

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Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy

29 September 2017

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The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells

29 September 2017

1 reference

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Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells

29 September 2017

1 reference

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Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element

29 September 2017

1 reference

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Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

29 September 2017

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Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells

29 September 2017

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

29 September 2017

1 reference

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Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

29 September 2017

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Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Stimulated endocrine cell proliferation and differentiation in transplanted human pancreatic islets: effects of the ob gene and compensatory growth of the implantation organ.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Determinants of glucose toxicity and its reversibility in the pancreatic islet beta-cell line, HIT-T15.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Glucotoxicity inhibits late steps of insulin exocytosis.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Intraislet endothelial cells contribute to revascularization of transplanted pancreatic islets

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

β-cell metabolic alterations under chronic nutrient overload in rat and human islets

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Susceptibility to fatty acid-induced β-cell dysfunction is enhanced in prediabetic diabetes-prone biobreeding rats: a potential link between β-cell lipotoxicity and islet inflammation

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Control of pancreatic β cell regeneration by glucose metabolism.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Amyloid oligomers in diabetic and nondiabetic human pancreas

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Pancreatic beta-cell mass in European subjects with type 2 diabetes

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Combination of the dipeptidyl peptidase IV inhibitor LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] with the angiotensin II type 1 receptor antagonist valsartan [N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]m

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

A novel high-affinity peptide antagonist to the insulin receptor

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.

4 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855919

Chronic inflammation exacerbates glucose metabolism disorders in C57BL/6J mice fed with high-fat diet.

4 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27064285

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression of human islet amyloid polypeptide/amylin impairs insulin secretion in mouse pancreatic beta cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27064285

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI83657

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27064285%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27064285%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

PubMed publication ID

27064285

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27064285%20AND%20SRC:MED&resulttype=core&format=json