N-glycan structure dictates extension of protein folding or onset of disposal (Q36825595)

16 August 2017

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title

N-glycan structure dictates extension of protein folding or onset of disposal (English)

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16 August 2017

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Maurizio Molinari

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16 August 2017

publication date

1 June 2007

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16 August 2017

published in

Nature Chemical Biology

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16 August 2017

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16 August 2017

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16 August 2017

page(s)

313-320

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Setting the standards: quality control in the secretory pathway

16 August 2017

cites work

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Minor folding defects trigger local modification of glycoproteins by the ER folding sensor GT

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Carbohydrates act as sorting determinants in ER-associated degradation of tyrosinase

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The ER protein folding sensor UDP-glucose glycoprotein-glucosyltransferase modifies substrates distant to local changes in glycoprotein conformation

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A window of opportunity: timing protein degradation by trimming of sugars and ubiquitins

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Endoplasmic reticulum-associated degradation of mammalian glycoproteins involves sugar chain trimming to Man6-5GlcNAc2.

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EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.

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EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin

21 January 2018

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21 January 2018

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Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload

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21 January 2018

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21 January 2018

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Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications.

21 January 2018

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21 January 2018

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The role of hydrophobic interactions in initiation and propagation of protein folding

21 January 2018

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Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress

21 January 2018

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Evidence of CFTR function in cystic fibrosis after systemic administration of 4-phenylbutyrate

21 January 2018

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

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Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency

21 January 2018

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Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease

21 January 2018

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Pharmacological chaperones: potential treatment for conformational diseases.

21 January 2018

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Pharmacological chaperones: a new twist on receptor folding.

21 January 2018

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Rescue of folding defects in ABC transporters using pharmacological chaperones

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Glycoproteins form mixed disulphides with oxidoreductases during folding in living cells

21 January 2018

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ERp57 and PDI: multifunctional protein disulfide isomerases with similar domain architectures but differing substrate-partner associations.

21 January 2018

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7 January 2021

Biosynthesis and degradation of CFTR.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO880

7 January 2021

A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation

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https://api.crossref.org/works/10.1038%2FNCHEMBIO880

7 January 2021

The endoplasmic reticulum glucosyltransferase recognizes nearly native glycoprotein folding intermediates

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7 January 2021

Recognition of the oligosaccharide and protein moieties of glycoproteins by the UDP-Glc:glycoprotein glucosyltransferase

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https://api.crossref.org/works/10.1038%2FNCHEMBIO880

7 January 2021

Different fates of the oligosaccharide moieties of lipid intermediates

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https://api.crossref.org/works/10.1038%2FNCHEMBIO880

7 January 2021

EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming

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https://api.crossref.org/works/10.1038%2FNCHEMBIO880

7 January 2021

Degradation from the endoplasmic reticulum: disposing of newly synthesized proteins

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7 January 2021

A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation

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https://api.crossref.org/works/10.1038%2FNCHEMBIO880

7 January 2021

A time-dependent phase shift in the mammalian unfolded protein response

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7 January 2021

Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO880

7 January 2021

Delta F508 CFTR pool in the endoplasmic reticulum is increased by calnexin overexpression.

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO880

7 January 2021

Lack of effect of oral 4-phenylbutyrate on serum alpha-1-antitrypsin in patients with alpha-1-antitrypsin deficiency: a preliminary study

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https://api.crossref.org/works/10.1038%2FNCHEMBIO880

7 January 2021

Getting into the fold

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7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO880

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release_m4s7syycybcpnbk6tzibjg3kjq

16 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/m4s7syycybcpnbk6tzibjg3kjq

24 November 2022

mapped directly with Wikidata item

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