Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes (Q36796096)

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scientific article published on 28 December 2012

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English	Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes	scientific article published on 28 December 2012

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scholarly article

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21 February 2020

Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes (English)

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21 February 2020

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Mohammed Bensellam

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21 February 2020

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21 February 2020

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Jeng Yie Chan

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21 February 2020

Jude Luzuriaga

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21 February 2020

D Ross Laybutt

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21 February 2020

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28 December 2012

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21 February 2020

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21 February 2020

62

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21 February 2020

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21 February 2020

1557-1568

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21 February 2020

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8 September 2021

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April 2022 Public Data File from Crossref

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1 reference

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The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells

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29 September 2017

Deficiency of Atf3, an adaptive-response gene, protects islets and ameliorates inflammation in a syngeneic mouse transplantation model.

1 reference

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29 September 2017

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Lipid receptors and islet function: therapeutic implications?

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29 September 2017

Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets

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29 September 2017

Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

1 reference

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29 September 2017

The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality.

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GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells

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Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

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Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

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1 reference

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1 reference

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1 reference

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5 September 2018

Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/23274897

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A time-dependent phase shift in the mammalian unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/23274897

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23274897

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB12-0701

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23274897%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23274897%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23274897%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

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