Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data (Q36795109)

16 August 2017

Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: comparison with experimental data (English)

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16 August 2017

1 reference

L T Baxter

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16 August 2017

R K Jain

series ordinal

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16 August 2017

language of work or name

English

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publication date

1 February 1996

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British Journal of Cancer

16 August 2017

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16 August 2017

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16 August 2017

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16 August 2017

447-456

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16 August 2017

Pharmacokinetic modeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2074453

The experimental development of bioreductive drugs and their role in cancer therapy.

29 September 2017

1 reference

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Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent

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1 reference

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EO9: relationship between DT-diaphorase levels and response in vitro and in vivo

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The single cell gel electrophoresis assay (comet assay): A European review

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Antibody directed enzymes revive anti-cancer prodrugs concept

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Anti-tumor effects of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate

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Microvascular permeability of normal and neoplastic tissues

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Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay

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1 reference

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Definitive evidence for hypoxic cells influencing cure in cancer therapy

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Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors

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AQ4N: an alkylaminoanthraquinone N-oxide showing bioreductive potential and positive interaction with radiation in vivo

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A cytotoxic agent can be generated selectively at cancer sites

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The dynamics of tumor cords in an irradiated mouse mammary carcinoma with a large hypoxic cell component.

27 June 2018

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A modeling analysis of monoclonal antibody percolation through tumors: a binding-site barrier.

27 June 2018

1 reference

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1 reference

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Specific activation of the prodrug mitomycin phosphate by a bispecific anti-CD30/anti-alkaline phosphatase monoclonal antibody

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Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism

27 June 2018

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Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.

27 June 2018

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Three-step monoclonal antibody tumor targeting in carcinoembryonic antigen-positive patients

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Ablation of human choriocarcinoma xenografts in nude mice by antibody-directed enzyme prodrug therapy (ADEPT) with three novel compounds

27 June 2018

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Bifunctional antibody: a binary radiopharmaceutical delivery system for imaging colorectal carcinoma

27 June 2018

1 reference

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Molecular and functional characterisation of a fusion protein suited for tumour specific prodrug activation

27 June 2018

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Specific activation of glucuronide prodrugs by antibody-targeted enzyme conjugates for cancer therapy

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Hypobaric hypoxia: A method for testing bioreductive drugs in vivo

27 June 2018

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Monoclonal antibody-beta-lactamase conjugates for the activation of a cephalosporin mustard prodrug

27 June 2018

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1 reference

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A distributed pharmacokinetic model of two-step imaging and treatment protocols: application to streptavidin-conjugated monoclonal antibodies and radiolabeled biotin.

27 June 2018

1 reference

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Streptavidin distribution in metastatic tumors pretargeted with a biotinylated monoclonal antibody: theoretical and experimental pharmacokinetics.

5 September 2018

1 reference

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Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.

5 September 2018

1 reference

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In vitro and in vivo activities of monoclonal antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate

5 September 2018

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Barriers to drug delivery in solid tumors

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Extravascular diffusion in normal and neoplastic tissues

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Variability in the expression of xenobiotic-metabolizing enzymes during the growth cycle of rat hepatoma cells

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Investigations of avidin and biotin for imaging applications

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Growth fraction measured using the comet assay

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Prodrugs of doxorubicin and melphalan and their activation by a monoclonal antibody-penicillin-G amidase conjugate

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Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice

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Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone

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Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure

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Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbB2 p185

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Radiation-induced reoxygenation in the SCCVII murine tumour: evidence for a decrease in oxygen consumption and an increase in tumour perfusion

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Aliphatic amine N-oxides of DNA binding agents as bioreductive drugs

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Enhancement of the in vitro and in vivo antitumor activities of phosphorylated mitomycin C and etoposide derivatives by monoclonal antibody-alkaline phosphatase conjugates

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Identifiers

DOI

10.1038/BJC.1996.80

1 reference

16 August 2017

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16 August 2017

PubMed publication ID

8595158

1 reference