Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase (Q36693033)

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scientific article published on 14 January 2016

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English	Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase	scientific article published on 14 January 2016

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Structure-based approach to the identification of a novel group of selective glucosamine analogue inhibitors of Trypanosoma cruzi glucokinase (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Trypanosoma cruzi

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Ana Rodriguez

9

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author name string

Edward L D'Antonio

1

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Europe PubMed Central

PMC publication ID

15 August 2017

Mason S Deinema

2

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Europe PubMed Central

PMC publication ID

15 August 2017

Sean P Kearns

3

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Europe PubMed Central

PMC publication ID

15 August 2017

Tyler A Frey

4

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Europe PubMed Central

PMC publication ID

15 August 2017

Scott Tanghe

5

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Europe PubMed Central

PMC publication ID

15 August 2017

Kay Perry

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Timothy A Roy

7

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Hanna S Gracz

8

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Europe PubMed Central

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15 August 2017

Jennifer D'Antonio

10

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Europe PubMed Central

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15 August 2017

language of work or name

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publication date

14 January 2016

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15 August 2017

Molecular and Biochemical Parasitology

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Europe PubMed Central

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15 August 2017

204

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Europe PubMed Central

PMC publication ID

15 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

64-76

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Automated high-content assay for compounds selectively toxic to Trypanosoma cruzi in a myoblastic cell line

1 reference

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Deciphering key features in protein structures with the new ENDscript server

1 reference

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1 reference

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Identification of a new class of glucokinase activators through structure-based design

1 reference

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Ligand efficiency indices for effective drug discovery

1 reference

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1 reference

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1 reference

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1 reference

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The active conformation of human glucokinase is not altered by allosteric activators

1 reference

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Glycolysis in the african trypanosome: targeting enzymes and their subcellular compartments for therapeutic development

1 reference

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Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

1 reference

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Trypanosoma cruzi and Chagas' Disease in the United States

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Activity in vivo of anti-Trypanosoma cruzi compounds selected from a high throughput screening

1 reference

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Quercetin, a fluorescent bioflavanoid, inhibits Trypanosoma brucei hexokinase 1

1 reference

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A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity

1 reference

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1 reference

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Chagas disease in Spain, the United States and other non-endemic countries

1 reference

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Crystallographic model quality at a glance

1 reference

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Challenges and opportunities for primary, secondary, and tertiary prevention of Chagas' disease

1 reference

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The challenges of Chagas Disease-- grim outlook or glimmer of hope

1 reference

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The crystal structure of Trypanosoma cruzi glucokinase reveals features determining oligomerization and anomer specificity of hexose-phosphorylating enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794339

30 September 2017

Inference of macromolecular assemblies from crystalline state

1 reference

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Differences in energy metabolism between trypanosomatidae

1 reference

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30 September 2017

Energy metabolism of trypanosomatids: adaptation to available carbon sources

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794339

30 September 2017

Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794339

30 September 2017

Structural and functional implications of the hexokinase-nickel interaction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4794339

30 September 2017

Hypothesis: structures, evolution, and ancestor of glucose kinases in the hexokinase family

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Chemotherapy of trypanosomiases and leishmaniasis

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Experimental and in silico analyses of glycolytic flux control in bloodstream form Trypanosoma brucei

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Crystal structures of Escherichia coli ATP-dependent glucokinase and its complex with glucose

1 reference

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The CCP4 suite: programs for protein crystallography

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STRIDE: a web server for secondary structure assignment from known atomic coordinates of proteins

1 reference

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Tests of cytoplasmic RNA interference (RNAi) and construction of a tetracycline-inducible T7 promoter system in Trypanosoma cruzi.

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30 September 2017

The trypanosomiases.

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1 reference

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Glycolysis as a target for the design of new anti-trypanosome drugs.

1 reference

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Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase

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Knowledge-based protein secondary structure assignment

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Site-directed mutagenesis studies on the determinants of sugar specificity and cooperative behavior of human beta-cell glucokinase

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Aerobic fermentation of glucose by trypanosomatids

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High resolution crystal structures of yeast hexokinase complexes with substrates, activators, and inhibitors. Evidence for an allosteric control site

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The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1.

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5 September 2018

Molecular and biochemical characterization of novel glucokinases from Trypanosoma cruzi and Leishmania spp.

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Molecular and biochemical characterization of hexokinase from Trypanosoma cruzi

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Sequencing, modeling, and selective inhibition of Trypanosoma brucei hexokinase

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Long term evaluation of etiological treatment of chagas disease with benznidazole.

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Hexose uptake in Trypanosoma cruzi: structure-activity relationship between substrate and transporter.

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Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies

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Aerobic glucose fermentation by Trypanosoma cruzi axenic culture amastigote-like forms during growth and differentiation to epimastigotes

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Yeast Hexokinase Inhibitors Designed from the 3-D Enzyme Structure Rebuilding

1 reference

https://pubmed.ncbi.nlm.nih.gov/26778112

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.MOLBIOPARA.2015.12.004

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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