Genetics of autoimmune diseases--disorders of immune homeostasis (Q36670483)

15 August 2017

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title

Genetics of autoimmune diseases--disorders of immune homeostasis (English)

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15 August 2017

Peter K Gregersen

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15 August 2017

Timothy W Behrens

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15 August 2017

publication date

1 December 2006

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15 August 2017

published in

Nature Reviews Genetics

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15 August 2017

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15 August 2017

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15 August 2017

page(s)

917-928

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Paul Ehrlich, archives and the history of immunology

15 August 2017

cites work

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

21 January 2018

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21 January 2018

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Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.

21 January 2018

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Familial lupus erythematosus. Clinical and immunologic features of 125 multiplex families

21 January 2018

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A central role for central tolerance

21 January 2018

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Genetic lesions in T-cell tolerance and thresholds for autoimmunity.

21 January 2018

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Regulatory T cells in immunologic self-tolerance and autoimmune disease

21 January 2018

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In vivo instruction of suppressor commitment in naive T cells

21 January 2018

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

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Control of regulatory T cell development by the transcription factor Foxp3

21 January 2018

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

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A function for interleukin 2 in Foxp3-expressing regulatory T cells

21 January 2018

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How do CD4+CD25+ regulatory T cells control autoimmunity?

21 January 2018

1 reference

Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

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The cellular mechanism of Aire control of T cell tolerance.

21 January 2018

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Positional cloning of the APECED gene

21 January 2018

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Autoimmune polyendocrine syndromes

21 January 2018

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Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individuals

21 January 2018

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Remapping the insulin gene/IDDM2 locus in type 1 diabetes

21 January 2018

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The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

21 January 2018

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Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

21 January 2018

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Association of the TSHR gene with Graves' disease: the first disease specific locus

21 January 2018

1 reference

Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome

21 January 2018

1 reference

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

21 January 2018

1 reference

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

21 January 2018

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

21 January 2018

1 reference

Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease

21 January 2018

1 reference

Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

21 January 2018

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Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

21 January 2018

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The dichotomous role of IL-2: tolerance versus immunity.

21 January 2018

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Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms

21 January 2018

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The B7/CD28 costimulatory family in autoimmunity

21 January 2018

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CD28 and ICOS: similar or separate costimulators of T cells?

21 January 2018

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Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity

21 January 2018

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

21 January 2018

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CTLA4 gene polymorphism and autoimmunity

21 January 2018

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

21 January 2018

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Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4

21 January 2018

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Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

21 January 2018

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Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

21 January 2018

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A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

21 January 2018

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New battlefields for costimulation

21 January 2018

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Tissue expression of PD-L1 mediates peripheral T cell tolerance.

21 January 2018

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21 January 2018

The B7 family revisited

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Role of PTPN22 in type 1 diabetes and other autoimmune diseases

21 January 2018

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Identification of substrates of human protein-tyrosine phosphatase PTPN22

21 January 2018

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A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

21 January 2018

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A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis

21 January 2018

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Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus

21 January 2018

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Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.

21 January 2018

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Association of the PTPN22*R620W polymorphism with autoimmune myasthenia gravis.

21 January 2018

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Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

21 January 2018

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PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells

21 January 2018

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PTPN22: setting thresholds for autoimmunity

21 January 2018

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PTPN22 and autoimmune disease

21 January 2018

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Gaining insight into PTPN22 and autoimmunity

21 January 2018

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The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis

21 January 2018

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Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations

21 January 2018

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PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis

21 January 2018

1 reference

The effects of human population structure on large genetic association studies

21 January 2018

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European population substructure: clustering of northern and southern populations

21 January 2018

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Principal components analysis corrects for stratification in genome-wide association studies

21 January 2018

1 reference

Fcgamma receptors: old friends and new family members

21 January 2018

1 reference

Fc receptors and their role in immune regulation and autoimmunity

21 January 2018

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A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor

21 January 2018

1 reference

Haplotype structure of TNFRSF5-TNFSF5 (CD40-CD40L) and association analysis in systemic lupus erythematosus

21 January 2018

1 reference

C1q: its functions within the innate and adaptive immune responses and its role in lupus autoimmunity

21 January 2018

1 reference

Pathogen recognition and innate immunity

21 January 2018

1 reference

Intracellular pattern recognition receptors in the host response

21 January 2018

1 reference

Genetics of Crohn disease, an archetypal inflammatory barrier disease

21 January 2018

1 reference

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

21 January 2018

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Toll-like receptors, endogenous ligands, and systemic autoimmune disease.

21 January 2018

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Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

21 January 2018

1 reference

The type I interferon system in systemic lupus erythematosus

21 January 2018

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The emerging role of interferon in human systemic lupus erythematosus

21 January 2018

1 reference

Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus

21 January 2018

1 reference

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

21 January 2018

1 reference

Genetic analysis of genome-wide variation in human gene expression

21 January 2018

1 reference

The central role of the alternative complement pathway in human disease

21 January 2018

1 reference

Systemic lupus erythematosus, complement deficiency, and apoptosis

21 January 2018

1 reference

Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus

21 January 2018

1 reference

Mannose binding lectin (MBL) polymorphisms associated with low MBL production in patients with dermatomyositis.

21 January 2018

1 reference

Protective molecules--C-reactive protein (CRP), serum amyloid P (SAP), pentraxin3 (PTX3), mannose-binding lectin (MBL), and apolipoprotein A1 (Apo A1), and their autoantibodies: prevalence and clinical significance in autoimmunity

21 January 2018

1 reference

A Tlr7 translocation accelerates systemic autoimmunity in murine lupus

21 January 2018

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Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication

21 January 2018

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Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

21 January 2018

1 reference

Systemic lupus erythematosus in a multi-ethnic cohort (LUMINA) XXXII: [corrected] contributions of admixture and socioeconomic status to renal involvement

21 January 2018

1 reference

Ethnicity and mortality from systemic lupus erythematosus in the US.

21 January 2018

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Replication validity of genetic association studies

21 January 2018

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Complement factor H polymorphism in age-related macular degeneration

21 January 2018

1 reference

The allelic architecture of human disease genes: common disease-common variant... or not?

21 January 2018

1 reference

Genome-wide association studies for common diseases and complex traits

21 January 2018

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Genome-wide association studies: theoretical and practical concerns

21 January 2018

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Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in women

21 January 2018

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A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination

21 January 2018

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The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide

21 January 2018

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Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles

21 January 2018

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A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis

21 January 2018

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Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis

21 January 2018

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Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure

21 January 2018

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Genes, environment and the value of prospective cohort studies

21 January 2018

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Genetic analysis of autoimmune disease

21 January 2018

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Genetic control of autoimmunity in Type I diabetes and associated disorders

21 January 2018

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Susceptibility genes in thyroid autoimmunity

21 January 2018

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HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course

21 January 2018

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Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus.

21 January 2018

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Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope

21 January 2018

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The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

21 January 2018

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Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

21 January 2018

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Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

21 January 2018

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Rheumatoid arthritis is already expensive during the first year of the disease (the Swedish TIRA project)

21 January 2018

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Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus

31 March 2020

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Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes

31 March 2020

1 reference

Trophoblast CD274 (B7-H1) is differentially expressed across gestation: influence of oxygen concentration

31 March 2020

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Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus

31 March 2020

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A haplotype map of the human genome

31 March 2020

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Influence of the HLA-DRB1 locus on susceptibility and severity in rheumatoid arthritis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG1944

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15 August 2017

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