Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4 (Q36661584)

15 August 2017

Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4 (English)

1 reference

15 August 2017

Françoise Meylan

1 reference

15 August 2017

Julio Gomez-Rodriguez

1 reference

15 August 2017

Robin Handon

1 reference

15 August 2017

Erika T Hayes

1 reference

15 August 2017

Stacie M Anderson

1 reference

15 August 2017

Martha R Kirby

1 reference

15 August 2017

Richard M Siegel

1 reference

15 August 2017

Pamela L Schwartzberg

1 reference

15 August 2017

language of work or name

English

0 references

publication date

3 March 2016

1 reference

15 August 2017

Nature Communications

1 reference

15 August 2017

1 reference

15 August 2017

10857

1 reference

Creative Commons Attribution 4.0 International

15 August 2017

start time

3 March 2016

1 reference

April 2022 Public Data File from Crossref

copyrighted

0 references

cites work

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The development and in vivo function of T helper 9 cells

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The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells.

30 September 2017

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TH9 cells are required for tissue mast cell accumulation during allergic inflammation

30 September 2017

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The signaling symphony: T cell receptor tunes cytokine-mediated T cell differentiation

30 September 2017

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Complex interactions of transcription factors in mediating cytokine biology in T cells

30 September 2017

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Nitric oxide enhances Th9 cell differentiation and airway inflammation

30 September 2017

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MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion

30 September 2017

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BCL6 controls Th9 cell development by repressing Il9 transcription

30 September 2017

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Counter-regulation of T cell effector function by differentially activated p38.

30 September 2017

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IRF4 at the crossroads of effector T-cell fate decision

30 September 2017

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Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression

30 September 2017

1 reference

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Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells

30 September 2017

1 reference

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Th9 cells, new players in adaptive immunity.

30 September 2017

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Interferon regulatory factor 4 sustains CD8(+) T cell expansion and effector differentiation

30 September 2017

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Orai1-NFAT signalling pathway triggered by T cell receptor stimulation

30 September 2017

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Early signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct T-helper cell subsets

30 September 2017

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Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

OX40 signaling favors the induction of T(H)9 cells and airway inflammation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Nuclear factor of activated T cells 1 (NFAT1)-induced permissive chromatin modification facilitates nuclear factor-κB (NF-κB)-mediated interleukin-9 (IL-9) transactivation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Activin A and TGF-β promote T(H)9 cell-mediated pulmonary allergic pathology.

30 September 2017

1 reference

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STAT5 is a potent negative regulator of TFH cell differentiation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

STAT6-dependent regulation of Th9 development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross‐regulation of cytokine production and T‐cell fates

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls

30 September 2017

1 reference

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The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.

30 September 2017

1 reference

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Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase

30 September 2017

1 reference

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IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Tec family kinases in T lymphocyte development and function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Selective Itk inhibitors block T-cell activation and murine lung inflammation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Attenuation of Immunological Symptoms of Allergic Asthma in Mice Lacking the Tyrosine Kinase ITK

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

DNA array analysis of interleukin-2-regulated immediate/early genes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Expression of interleukin-9 leads to Th2 cytokine-dominated responses and fatal enteropathy in mice with chronic Schistosoma mansoni infections

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Tec family kinases in lymphocyte signaling and function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Inhibition of interleukin 2 signaling and signal transducer and activator of transcription (STAT)5 activation during T cell receptor-mediated feedback inhibition of T cell expansion

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Expression of interleukin 9 in the lungs of transgenic mice causes airway inflammation, mast cell hyperplasia, and bronchial hyperresponsiveness

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE).

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

The association of a single-nucleotide polymorphism of the IL-2 inducible T-cell Kinase gene with asthma.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

A key role for Itk in both IFN gamma and IL-4 production by NKT cells

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Anti-interleukin-9 antibody treatment inhibits airway inflammation and hyperreactivity in mouse asthma model.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Effect of anti-mIL-9 antibody on the development of pulmonary inflammation and airway hyperresponsiveness in allergic mice

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

20 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4782063

Phenotype and functions of memory Tfh cells in human blood

20 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS10857

Mutation of Tec family kinases alters T helper cell differentiation

21 January 2018

1 reference

12 December 2020

Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytes

1 reference

12 December 2020

IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma

1 reference

12 December 2020

Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice

1 reference

12 December 2020

IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma

1 reference

12 December 2020

Peripheral blood Th9 cells and eosinophil apoptosis in asthma patients

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCOMMS10857

1 reference

15 August 2017

0 references

1 reference

15 August 2017

PubMed publication ID

26936133

1 reference