Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis (Q36618989)

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scientific article published on 30 October 2015

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English	Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis	scientific article published on 30 October 2015

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26528756%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis (English)

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28 February 2020

platelet aggregation

1 reference

based on heuristic

inferred from title

cancer metastasis

1 reference

based on heuristic

inferred from title

5

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28 February 2020

6

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28 February 2020

author name string

Yao-Wen Chang

1

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28 February 2020

Pei-Wen Hsieh

2

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28 February 2020

Yu-Tsui Chang

3

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28 February 2020

Meng-Hong Lu

4

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28 February 2020

Hsiang-Ruei Liao

7

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28 February 2020

Ju-Chien Cheng

8

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28 February 2020

Ching-Ping Tseng

9

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28 February 2020

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1 December 2015

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28 February 2020

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28 February 2020

6

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28 February 2020

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28 February 2020

42733-42748

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28 February 2020

A platform of C-type lectin-like receptor CLEC-2 for binding O-glycosylated podoplanin and nonglycosylated rhodocytin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Anti-platelet agents augment cisplatin nanoparticle cytotoxicity by enhancing tumor vasculature permeability and drug delivery

1 reference

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30 September 2017

Disabled-2 is required for efficient hemostasis and platelet activation by thrombin in mice

1 reference

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30 September 2017

Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis.

1 reference

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30 September 2017

Mechanistic explanation for platelet contribution to cancer metastasis

1 reference

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30 September 2017

Inhibitory effects of polypeptides derived from a snake venom C-type lectin, aggretin, on tumor cell-induced platelet aggregation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Platelets promote tumor growth and metastasis via direct interaction between Aggrus/podoplanin and CLEC-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

PDK1 regulates platelet activation and arterial thrombosis

1 reference

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30 September 2017

Inhibition of MCF-7 breast cancer cell-induced platelet aggregation using a combination of antiplatelet drugs

1 reference

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30 September 2017

Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors

1 reference

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30 September 2017

The impact of Aggrus/podoplanin on platelet aggregation and tumour metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Podoplanin: emerging functions in development, the immune system, and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

PI3K-PKB/Akt pathway

1 reference

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30 September 2017

Chimeric anti-podoplanin antibody suppresses tumor metastasis through neutralization and antibody-dependent cellular cytotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Differential inhibition of tumour cell-induced platelet aggregation by the nicotinate aspirin prodrug (ST0702) and aspirin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

The Syk-kinase inhibitor R406 impairs platelet activation and monocyte tissue factor expression triggered by heparin-PF4 complex directed antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Novel platelet activation receptor CLEC-2: from discovery to prospects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

High-level expression of podoplanin in benign and malignant soft tissue tumors: Immunohistochemical and quantitative real-time RT-PCR analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

The synthesis and biologic evaluation of anti-platelet and cytotoxic β-nitrostyrenes

1 reference

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30 September 2017

Tumor lymphangiogenesis and metastasis to lymph nodes induced by cancer cell expression of podoplanin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Akt signaling in platelets and thrombosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

GPVI and CLEC-2 in hemostasis and vascular integrity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Deadly allies: the fatal interplay between platelets and metastasizing cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Novel interactions in platelet biology: CLEC-2/podoplanin and laminin/GPVI.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Use of low-molecular-weight heparin to decrease mortality in mice after intracardiac injection of tumor cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

The role of podoplanin in tumor progression and metastasis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Platelet aggregation in the formation of tumor metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Renal cells activate the platelet receptor CLEC-2 through podoplanin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

The evaluation and structure-activity relationships of 2-benzoylaminobenzoic esters and their analogues as anti-inflammatory and anti-platelet aggregation agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

The potential role of podoplanin in tumour invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4767466

30 September 2017

Anti-metastatic effect of a non-anticoagulant low-molecular-weight heparin versus the standard low-molecular-weight heparin, enoxaparin

1 reference

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30 September 2017

The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2.

1 reference

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30 September 2017

Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition.

1 reference

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30 September 2017

Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet-aggregation-stimulating domain

1 reference

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30 September 2017

Platelets and metastasis revisited: a novel fatty link

1 reference

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30 September 2017

Platelet--cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation

1 reference

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30 September 2017

Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GpIIb/IIIa antagonist XV454.

1 reference

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30 September 2017

Antimetastatic effect of tinzaparin, a low-molecular-weight heparin

1 reference

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30 September 2017

Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets

1 reference

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Role of von Willebrand factor in tumour cell-induced platelet aggregation: differential regulation by NO and prostacyclin

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30 September 2017

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1 reference

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28 June 2018

Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

1 reference

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28 June 2018

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1 reference

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28 June 2018

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1 reference

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20 September 2018

A novel targeting therapy of malignant mesothelioma using anti-podoplanin antibody.

1 reference

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Prevention of hematogenous metastasis by neutralizing mice and its chimeric anti‐Aggrus/podoplanin antibodies

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20 September 2018

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1 reference

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20 September 2018

Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosine kinase inhibitor

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Prognostic value of podoplanin expression in oral squamous cell carcinoma--a regression model auxiliary to UICC classification

1 reference

https://pubmed.ncbi.nlm.nih.gov/26528756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significance of lymphangiogenesis as assessed by immunohistochemistry for podoplanin in patients with esophageal carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26528756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity

1 reference

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12 December 2020

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Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of high podoplanin expression after chemoradiotherapy in esophageal squamous cell carcinoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/26528756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired thrombin generation in Reelin-deficient mice: a potential role of plasma Reelin in hemostasis

1 reference

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12 December 2020

based on heuristic

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The effects of an inhibitor of diglyceride lipase on collagen-induced platelet activation

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https://pubmed.ncbi.nlm.nih.gov/26528756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.18632/ONCOTARGET.5811

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Europe PubMed Central

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28 February 2020

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Europe PubMed Central

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28 February 2020

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Europe PubMed Central

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28 February 2020

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