The consequences of lysosomotropism on the design of selective cathepsin K inhibitors (Q36572175)

15 August 2017

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title

The consequences of lysosomotropism on the design of selective cathepsin K inhibitors (English)

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15 August 2017

W Cameron Black

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15 August 2017

M David Percival

series ordinal

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15 August 2017

publication date

1 October 2006

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15 August 2017

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15 August 2017

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15 August 2017

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15 August 2017

page(s)

1525-1535

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Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design.

15 August 2017

cites work

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The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics

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Cathepsin B inactivation attenuates hepatic injury and fibrosis during cholestasis

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Increased serum cathepsin S in patients with atherosclerosis and diabetes

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Lysosomal cysteine proteases: structure, function and inhibition of cathepsins

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Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis.

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Osteopetrosis and osteoporosis: two sides of the same coin

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Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

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Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl

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Non-covalent cathepsin K inhibitors for the treatment of osteoporosis

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The pH dependencies of individual rate constants in papain-catalyzed reactions.

21 January 2018

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Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.

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Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development

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Crystal structure of human cathepsin K complexed with a potent inhibitor

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Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.

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Activity-based protein profiling: applications to biomarker discovery, in vivo imaging and drug discovery

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21 January 2018

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Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases

21 January 2018

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Activity-based probes that target diverse cysteine protease families

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An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells

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Irreversible inhibitors of serine, cysteine, and threonine proteases

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Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity

21 January 2018

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The potential role of lysosomes in tissue distribution of weak bases

21 January 2018

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The lysosomal cysteine proteases in MHC class II antigen presentation

21 January 2018

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Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption

21 January 2018

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Peptide ketobenzoxazole inhibitors bound to cathepsin K.

21 January 2018

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A novel class of nonpeptidic biaryl inhibitors of human cathepsin K.

21 January 2018

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Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K.

21 January 2018

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Synthesis, structure and conformation of partially-modified retro- and retro-inverso psi[NHCH(CF3)]Gly peptides.

21 January 2018

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Identification of a potent and selective non-basic cathepsin K inhibitor

21 January 2018

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Acute effects of bisphosphonates on new and traditional markers of bone resorption

21 January 2018

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Inhibition of cathepsin K by nitric oxide donors: evidence for the formation of mixed disulfides and a sulfenic acid

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/CBIC.200600149

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15 August 2017

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