Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein (Q36574049)

15 August 2017

Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein (English)

1 reference

15 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26683377%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Marton I Siklos

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26683377%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Esther L Calderon-Gierszal

1 reference

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9 June 2020

Lamiaa El-Shennawy

1 reference

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9 June 2020

Gergana Georgieva

1 reference

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9 June 2020

Emily N Thayer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26683377%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Gregory R J Thatcher

1 reference

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9 June 2020

Jonna Frasor

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26683377%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

language of work or name

English

0 references

publication date

18 December 2015

1 reference

Journal of Biological Chemistry

15 August 2017

1 reference

inferred from page(s)

published in

1 reference

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9 June 2020

volume

291

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9 June 2020

issue

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9 June 2020

page(s)

3639-3647

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26683377%20AND%20SRC:MED&resulttype=core&format=json

A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties.

9 June 2020

cites work

1 reference

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PHLDA1 expression is controlled by an estrogen receptor-NFκB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres

30 September 2017

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30 September 2017

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The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.

30 September 2017

1 reference

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Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism

30 September 2017

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30 September 2017

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Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling

30 September 2017

1 reference

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ErbB receptor tyrosine kinase/NF-κB signaling controls mammosphere formation in human breast cancer

30 September 2017

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Minireview: Inflammation: an instigator of more aggressive estrogen receptor (ER) positive breast cancers

30 September 2017

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CBP mediates NF-κB-dependent histone acetylation and estrogen receptor recruitment to an estrogen response element in the BIRC3 promoter

30 September 2017

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30 September 2017

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Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells

30 September 2017

1 reference

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Hallmarks of Cancer: The Next Generation

30 September 2017

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Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

30 September 2017

1 reference

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Genome-wide analysis of estrogen receptor alpha DNA binding and tethering mechanisms identifies Runx1 as a novel tethering factor in receptor-mediated transcriptional activation

30 September 2017

1 reference

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Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation

30 September 2017

1 reference

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An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

30 September 2017

1 reference

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The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies

30 September 2017

1 reference

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Association of reactive oxygen species levels and radioresistance in cancer stem cells

30 September 2017

1 reference

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Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis.

30 September 2017

1 reference

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Inactivation of NF-kappaB components by covalent binding of (-)-dehydroxymethylepoxyquinomicin to specific cysteine residues

30 September 2017

1 reference

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Cancer stem cells in breast: current opinion and future challenges.

30 September 2017

1 reference

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Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy

30 September 2017

1 reference

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Shared principles in NF-kappaB signaling

30 September 2017

1 reference

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Cancer stem cells: implications for the progression and treatment of metastatic disease.

30 September 2017

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IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells

30 September 2017

1 reference

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NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

30 September 2017

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Inhibitors of NF-kappaB signaling: 785 and counting

30 September 2017

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NF-kappaB and IKK as therapeutic targets in cancer

30 September 2017

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Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.

30 September 2017

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Activation of nuclear factor-kappaB (NFkappaB) identifies a high-risk subset of hormone-dependent breast cancers.

30 September 2017

1 reference

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In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

30 September 2017

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Prospective identification of tumorigenic breast cancer cells

30 September 2017

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NF-kappaB and breast cancer

30 September 2017

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A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

30 September 2017

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NF-kappaB in cancer: from innocent bystander to major culprit

30 September 2017

1 reference

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Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751401

Dimethylfumarate is an inhibitor of cytokine-induced nuclear translocation of NF-kappa B1, but not RelA in normal human dermal fibroblast cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751401

Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA

30 September 2017

1 reference

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Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer

30 September 2017

1 reference

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IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

30 September 2017

1 reference

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Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growth

30 September 2017

1 reference

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NF-kappa B, KBF1, dorsal, and related matters

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4751401

Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B.

30 September 2017

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Nuclear NF-κB/p65 expression and response to neoadjuvant chemotherapy in breast cancer

30 September 2017

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Dimethylfumarate inhibits NF-{kappa}B function at multiple levels to limit airway smooth muscle cell cytokine secretion.

21 September 2018

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Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens

21 September 2018

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Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype

21 September 2018

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Long-term safety aspects of systemic therapy with fumaric acid esters in severe psoriasis

21 September 2018

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Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition

21 September 2018

1 reference

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Dimethylfumarate inhibits TNF-induced nuclear entry of NF-kappa B/p65 in human endothelial cells

21 September 2018

1 reference

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The second wave in kinase cancer drugs

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26683377

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M115.679704

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26683377%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26683377%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

PubMed publication ID

26683377

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26683377%20AND%20SRC:MED&resulttype=core&format=json