Targeting signal transduction as a strategy to treat inflammatory diseases. (Q36506311)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16773072%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

review article

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title

Targeting signal transduction as a strategy to treat inflammatory diseases (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16773072%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

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Luke A J O'Neill

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16773072%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

14 August 2017

publication date

9 June 2006

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16773072%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

29 January 2020

published in

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29 January 2020

volume

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issue

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29 January 2020

page(s)

549-563

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New drugs for rheumatoid arthritis

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TNF alpha--a pivotal role in rheumatoid arthritis?

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Interleukin-17 family and IL-17 receptors

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A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

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Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

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The Toll-IL-1 receptor adaptor family grows to five members.

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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

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Triggering the interferon antiviral response through an IKK-related pathway

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Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

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Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

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Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction

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Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

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Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium

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Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

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RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

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A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses

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The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense

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Identification of a peptide derived from vaccinia virus A52R protein that inhibits cytokine secretion in response to TLR-dependent signaling and reduces in vivo bacterial-induced inflammation.

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RDP58 is a novel and potentially effective oral therapy for ulcerative colitis.

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

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Signalling pathways and molecular interactions of NOD1 and NOD2

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NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

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Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

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Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

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NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

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Unraveling the NALP-3/IL-1beta inflammasome: a big lesson from a small mutation

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Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.

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Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa.

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New advances and potential therapies for the treatment of asthma

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