Targeting N-type and T-type calcium channels for the treatment of pain (Q36437519)

14 August 2017

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title

Targeting N-type and T-type calcium channels for the treatment of pain (English)

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14 August 2017

Joseph G McGivern

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14 August 2017

language of work or name

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1 March 2006

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14 August 2017

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14 August 2017

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14 August 2017

issue

5-6

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14 August 2017

page(s)

245-253

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Lost Productive Time and Cost Due to Common Pain Conditions in the US Workforce

14 August 2017

cites work

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7 January 2021

The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord

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7 January 2021

Update on the neurophysiology of pain transmission and modulation: focus on the NMDA-receptor

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7 January 2021

Pain threshold changes in adjuvant-induced inflammation: a possible model of chronic pain in the mouse

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7 January 2021

Evidence that adjuvant arthritis in the rat is associated with chronic pain

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7 January 2021

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

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7 January 2021

Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain.

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7 January 2021

Calcium dependence of axotomized sensory neurons excitability.

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7 January 2021

Pharmacological strategies in relieving neuropathic pain

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7 January 2021

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.

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7 January 2021

A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury.

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7 January 2021

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat

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7 January 2021

Voltage-gated calcium channels as targets for the treatment of chronic pain

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7 January 2021

Ziconotide: neuronal calcium channel blocker for treating severe chronic pain

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7 January 2021

Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception.

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7 January 2021

Biochemical properties and subcellular distribution of an N-type calcium channel alpha 1 subunit

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7 January 2021

Regulation of presynaptic calcium channels by synaptic proteins

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7 January 2021

Localization of Ca2+ channel subtypes on rat spinal motor neurons, interneurons, and nerve terminals.

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7 January 2021

Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats.

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7 January 2021

Dorsal root ganglion neurons show increased expression of the calcium channel alpha2delta-1 subunit following partial sciatic nerve injury

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7 January 2021

Changes in expression of voltage-dependent ion channel subunits in dorsal root ganglia of rats with radicular injury and pain

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7 January 2021

Localization of N-type Ca2+ channels in the rat spinal cord following chronic constrictive nerve injury

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7 January 2021

Plastic change of N-type Ca channel expression after preconditioning is responsible for prostaglandin E2-induced long-lasting allodynia

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7 January 2021

Purification and sequence of a presynaptic peptide toxin from Conus geographus venom

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7 January 2021

Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom

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7 January 2021

Characteristics of [125I]omega-conotoxin MVIIA binding to rat neocortical membranes

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7 January 2021

Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes

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7 January 2021

Functional and physical coupling of voltage-sensitive calcium channels with exocytotic proteins: ramifications for the secretion mechanism

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7 January 2021

Release of calcitonin gene-related peptide like-immunoreactivity induced by electrical field stimulation from rat spinal afferents is mediated by conotoxin-sensitive calcium channels

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7 January 2021

Voltage-dependent calcium channel subtypes controlling somatic substance P release in the peripheral nervous system

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7 January 2021

The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Effects of spinally delivered N- and P-type voltage-dependent calcium channel antagonists on dorsal horn neuronal responses in a rat model of neuropathy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Actions of intrathecal omega-conotoxins CVID, GVIA, MVIIA, and morphine in acute and neuropathic pain in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Differential nociceptive responses in mice lacking the alpha(1B) subunit of N-type Ca(2+) channels

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Altered nociceptive response in mice deficient in the alpha(1B) subunit of the voltage-dependent calcium channel

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Adverse effects associated with the intrathecal administration of ziconotide

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7 January 2021

Antisympathetic and hemodynamic property of a dual L/N-type Ca(2+) channel blocker cilnidipine in rats

1 reference

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7 January 2021

Cardiovascular and autonomic effects of omega-conotoxins MVIIA and CVID in conscious rabbits and isolated tissue assays

1 reference

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7 January 2021

Cell-specific alternative splicing increases calcium channel current density in the pain pathway

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7 January 2021

Gabapentin: in postherpetic neuralgia

1 reference

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7 January 2021

Randomized double-blind study comparing the efficacy of gabapentin with amitriptyline on diabetic peripheral neuropathy pain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Gabapentin is a first line drug for the treatment of neuropathic pain in spinal cord injury

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Gabapentin for neuropathic cancer pain: a randomized controlled trial from the Gabapentin Cancer Pain Study Group

1 reference

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7 January 2021

Pregabalin relieves symptoms of painful diabetic neuropathy: a randomized controlled trial

1 reference

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7 January 2021

Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Relief of painful diabetic peripheral neuropathy with pregabalin: a randomized, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Pregabalin for the treatment of fibromyalgia syndrome: results of a randomized, double-blind, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Auxiliary subunits: essential components of the voltage-gated calcium channel complex.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Mechanism of action of alpha2delta ligands: voltage sensitive calcium channel (VSCC) modulators.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Gabapentin inhibits calcium currents in isolated rat brain neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

The effects of gabapentin on different ligand- and voltage-gated currents in isolated cortical neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

A study comparing the actions of gabapentin and pregabalin on the electrophysiological properties of cultured DRG neurones from neonatal rats

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Gabapentin may inhibit synaptic transmission in the mouse spinal cord dorsal horn through a preferential block of P/Q-type Ca2+ channels

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Gabapentin actions on ligand- and voltage-gated responses in cultured rodent neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Effects of phenytoin, carbamazepine, and gabapentin on calcium channels in hippocampal granule cells from patients with temporal lobe epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Gabapentin inhibits presynaptic Ca(2+) influx and synaptic transmission in rat hippocampus and neocortex

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Preferential action of gabapentin and pregabalin at P/Q-type voltage-sensitive calcium channels: inhibition of K+-evoked [3H]-norepinephrine release from rat neocortical slices

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Gabapentin fails to alter P/Q-type Ca2+ channel-mediated synaptic transmission in the hippocampus in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Gabapentin-mediated inhibition of voltage-activated Ca2+ channel currents in cultured sensory neurones is dependent on culture conditions and channel subunit expression.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Reduction by gabapentin of K+-evoked release of [3H]-glutamate from the caudal trigeminal nucleus of the streptozotocin-treated rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Evidence that gabapentin reduces neuropathic pain by inhibiting the spinal release of glutamate

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Chronic oral gabapentin reduces elements of central sensitization in human experimental hyperalgesia

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Gabapentin (neurontin) and S‐(+)‐3‐isobutylgaba represent a novel class of selective antihyperalgesic agents

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Gabapentin and pregabalin suppress tactile allodynia and potentiate spinal cord stimulation in a model of neuropathy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Calcium currents in rat thalamocortical relay neurones: kinetic properties of the transient, low-threshold current.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

A novel T-type current underlies prolonged Ca(2+)-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Calcium current variation between acutely isolated adult rat dorsal root ganglion neurons of different size

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Multiple Ca2+ currents elicited by action potential waveforms in acutely isolated adult rat dorsal root ganglion neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Cloning and characterization of alpha1H from human heart, a member of the T-type Ca2+ channel gene family

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Molecular characterization of a neuronal low-voltage-activated T-type calcium channel

1 reference

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7 January 2021

Nickel block of three cloned T-type calcium channels: low concentrations selectively block alpha1H.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Two new scorpion toxins that target voltage-gated Ca2+ and Na+ channels

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2)

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

A family of gamma-like calcium channel subunits

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Novel vistas of calcium-mediated signalling in the thalamus

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Low threshold calcium currents in rat cerebellar Purkinje cell dendritic spines are mediated by T-type calcium channels.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

T-type calcium channels mediate the transition between tonic and phasic firing in thalamic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Transient low-threshold Ca2+ current triggers burst firing through an afterdepolarizing potential in an adult mammalian neuron

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Calcium and calcium-activated currents in vagotomized rat primary vagal afferent neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Voltage-gated calcium currents in axotomized adult rat cutaneous afferent neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Axotomy- and autotomy-induced changes in Ca2+ and K+ channel currents of rat dorsal root ganglion neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Painful neuropathy decreases membrane calcium current in mammalian primary afferent neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Loss of T-type calcium current in sensory neurons of rats with neuropathic pain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Regulation of firing response gain by calcium-dependent mechanisms in vestibular nucleus neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Selective coupling of T-type calcium channels to SK potassium channels prevents intrinsic bursting in dopaminergic midbrain neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Wind-up of spinal cord neurones and pain sensation: much ado about something?

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Different kinetic properties of two T-type Ca2+ currents of rat reticular thalamic neurones and their modulation by enflurane

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Thalamus and neurogenic pain: physiological, anatomical and clinical data.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Thalamic Control of Visceral Nociception Mediated by T-Type Ca 2+ Channels

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Block of cloned human T-type calcium channels by succinimide antiepileptic drugs.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

On the action of the anti-absence drug ethosuximide in the rat and cat thalamus.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Effects of ethosuximide, a T-type Ca(2+) channel blocker, on dorsal horn neuronal responses in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Reversal of experimental neuropathic pain by T-type calcium channel blockers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Comparison of the effects of anticonvulsant drugs with diverse mechanisms of action in the formalin test in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Suggestion for another anti-epileptic drug to use for migraine prophylaxis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Mechanisms of T-type calcium channel blockade by zonisamide.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Open-label zonisamide for refractory migraine

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Successful use of zonisamide for central poststroke pain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

The effect of systemic zonisamide (Zonegran) on thermal hyperalgesia and mechanical allodynia in rats with an experimental mononeuropathy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

Nomenclature of voltage-gated calcium channels

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2805%2903662-7

7 January 2021

10.1016/S1359-6446(05)03662-7

Identifiers

DOI

1 reference

14 August 2017

1 reference