Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B. (Q36370851)

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13 February 2020

title

Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B (English)

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13 February 2020

Shuyun Rao

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13 February 2020

Sang-Yun Lee

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Jacqueline Perrigoue

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Roshan J Thapa

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13 February 2020

John R Jeffers

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13 February 2020

Michele Rhodes

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13 February 2020

Stephen Anderson

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13 February 2020

Tamas Oravecz

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13 February 2020

Roman A Timakhov

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13 February 2020

Rugang Zhang

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13 February 2020

Siddharth Balachandran

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Gerard P Zambetti

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13 February 2020

Joseph R Testa

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13 February 2020

A Thomas Look

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13 February 2020

Stephen P Hunger

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13 February 2020

language of work or name

English

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publication date

13 September 2012

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13 February 2020

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13 February 2020

volume

120

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issue

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page(s)

3764-3773

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Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma

13 February 2020

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Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis

30 September 2017

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Developmental arrest of T cells in Rpl22-deficient mice is dependent upon multiple p53 effectors

30 September 2017

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LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms

30 September 2017

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30 September 2017

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Ribosome-Mediated Specificity in Hox mRNA Translation and Vertebrate Tissue Patterning

30 September 2017

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Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis

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The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

30 September 2017

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30 September 2017

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LIN28 alters cell fate succession and acts independently of the let-7 microRNA during neurogliogenesis in vitro

30 September 2017

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An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

30 September 2017

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Ribosomal protein S7 is both a regulator and a substrate of MDM2

30 September 2017

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Lin28 promotes transformation and is associated with advanced human malignancies

30 September 2017

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High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

30 September 2017

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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

30 September 2017

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Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

30 September 2017

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A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

30 September 2017

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30 September 2017

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Selective blockade of microRNA processing by Lin28

30 September 2017

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30 September 2017

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30 September 2017

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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

30 September 2017

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30 September 2017

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Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint

30 September 2017

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Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma

30 September 2017

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30 September 2017

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

30 September 2017

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Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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21 September 2018

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21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22976955

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Retroviral-mediated insertional mutagenesis in zebrafish

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22976955

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Successful T-cell acute lymphoblastic leukemia treatment with proteasome inhibitor bortezomib based on evaluation of nuclear factor-κB activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22976955

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2012-03-415349

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13 February 2020

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13 February 2020

PubMed publication ID

22976955

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