Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based D (Q36370177)
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Language | Label | Description | Also known as |
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English | Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based D |
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Statements
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design (English)
Catherine M Ambler
David R Anderson
Brian P Boscoe
Andrea G Bree
Joanne I Brodfuehrer
Jeanne S Chang
Chulho Choi
Seungwon Chung
Kevin J Curran
Jacqueline E Day
Christoph M Dehnhardt
Ken Dower
Susan E Drozda
Richard K Frisbie
Lori K Gavrin
Joel A Goldberg
Seungil Han
Martin Hegen
David Hepworth
Heidi R Hope
Satwik Kamtekar
Iain C Kilty
Arthur Lee
Lih-Ling Lin
Michael D Lowe
John P Mathias
Heidi M Morgan
Elizabeth A Murphy
Nikolaos Papaioannou
Akshay Patny
Betsy S Pierce
Vikram R Rao
Eddine Saiah
Ivan J Samardjiev
Brian M Samas
Marina W H Shen
Julia H Shin
Holly H Soutter
Joseph W Strohbach
Peter T Symanowicz
Jennifer R Thomason
John D Trzupek
Richard Vargas
Fabien Vincent
Jiangli Yan