Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells (Q36378400)

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10 March 2020

title

Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells (English)

1 reference

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Human Induced Pluripotent Stem Cells

10 March 2020

main subject

hemopoiesis

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1 reference

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10 March 2020

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10 March 2020

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10 March 2020

Stella T Chou

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10 March 2020

Marta Byrska-Bishop

1 reference

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10 March 2020

Joanna M Tober

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10 March 2020

Yu Yao

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10 March 2020

Daniel Vandorn

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10 March 2020

Joanna B Opalinska

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10 March 2020

Jason A Mills

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10 March 2020

John Kim Choi

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10 March 2020

Nancy A Speck

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10 March 2020

Paul Gadue

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10 March 2020

Deborah L French

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10 March 2020

language of work or name

English

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publication date

8 October 2012

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Proceedings of the National Academy of Sciences of the United States of America

10 March 2020

published in

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10 March 2020

volume

109

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10 March 2020

issue

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10 March 2020

page(s)

17573-17578

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Perturbation of fetal liver hematopoietic stem and progenitor cell development by trisomy 21

10 March 2020

cites work

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Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells

30 September 2017

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Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.

30 September 2017

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30 September 2017

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30 September 2017

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A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

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Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis

30 September 2017

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Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

30 September 2017

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Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine.

30 September 2017

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Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome

30 September 2017

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30 September 2017

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The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

30 September 2017

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Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis

30 September 2017

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A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis.

30 September 2017

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Hematopoietic and endothelial differentiation of human induced pluripotent stem cells

30 September 2017

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Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome

30 September 2017

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30 September 2017

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Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

30 September 2017

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Trisomy 21 enhances human fetal erythro-megakaryocytic development

30 September 2017

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Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis

30 September 2017

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30 September 2017

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30 September 2017

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Highly penetrant myeloproliferative disease in the Ts65Dn mouse model of Down syndrome

30 September 2017

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Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures

30 September 2017

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Leukosialin (CD43) defines hematopoietic progenitors in human embryonic stem cell differentiation cultures

30 September 2017

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NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

30 September 2017

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Embryonic development of the human hematopoietic system

30 September 2017

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Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development

30 September 2017

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Origins of leukaemia in children with Down syndrome

30 September 2017

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Chromosome 21 and down syndrome: from genomics to pathophysiology

30 September 2017

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30 September 2017

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Gene expression from the aneuploid chromosome in a trisomy mouse model of down syndrome

30 September 2017

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Summaries of Affymetrix GeneChip probe level data

30 September 2017

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Hematopoietic cytokines, transcription factors and lineage commitment

30 September 2017

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30 September 2017

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To err (meiotically) is human: the genesis of human aneuploidy

30 September 2017

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Hematopoietic commitment during embryonic stem cell differentiation in culture

30 September 2017

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Embryonic----Fetal Hb switch in humans: studies on erythroid bursts generated by embryonic progenitors from yolk sac and liver

30 September 2017

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Human embryonic hemopoiesis. Kinetics of progenitors and precursors underlying the yolk sac----liver transition

30 September 2017

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30 September 2017

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Abnormalities in the myeloid progenitor compartment in Down syndrome fetal liver precede acquisition of GATA1 mutations

28 June 2018

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An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis

21 September 2018

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Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse.

21 September 2018

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Hematological abnormalities during the first week of life among neonates with Down syndrome: data from a multihospital healthcare system

21 September 2018

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Hematologic abnormalities in children with Down syndrome

21 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23045704

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hematopoietic defects in the Ts1Cje mouse model of Down syndrome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23045704

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1211175109

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23045704%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23045704%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

PubMed publication ID

23045704

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23045704%20AND%20SRC:MED&resulttype=core&format=json