Sigma-1R agonist improves motor function and motoneuron survival in ALS mice (Q36345436)

13 August 2017

Sigma-1R agonist improves motor function and motoneuron survival in ALS mice (English)

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amyotrophic lateral sclerosis

13 August 2017

1 reference

Xavier Navarro

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Renzo Mancuso

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Caty Casas

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Sara Oliván

1 reference

13 August 2017

Amaya Rando

series ordinal

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13 August 2017

Rosario Osta

series ordinal

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13 August 2017

1 October 2012

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13 August 2017

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13 August 2017

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13 August 2017

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13 August 2017

814-826

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describes a project that uses

13 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3480575/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Sigma receptor agonist 2-(4-morpholinethyl)1 phenylcyclohexanecarboxylate (Pre084) increases GDNF and BiP expression and promotes neuroprotection after root avulsion injury

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Calcium dysregulation in amyotrophic lateral sclerosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Microglia in ALS: the good, the bad, and the resting

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

The pharmacology of sigma-1 receptors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Cytoskeletal and activity-related changes in spinal motoneurons after root avulsion

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Ligand-dependent localization and intracellular stability of sigma-1 receptors in CHO-K1 cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Molecular biology of amyotrophic lateral sclerosis: insights from genetics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Immunocytochemical localization of the sigma(1) receptor in the adult rat central nervous system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Anti-amnesic and neuroprotective actions of the sigma-1 receptor agonist (-)-MR22 in rats with selective cholinergic lesion and amyloid infusion.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480575

Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-beta1.

29 June 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

Immunohistochemical localization of the sigma1-receptor in oligodendrocytes in the rat central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

Sigma receptors suppress multiple aspects of microglial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

The sigma receptor as a ligand-regulated auxiliary potassium channel subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

Sigma receptor activation reduces infarct size at 24 hours after permanent middle cerebral artery occlusion in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

Electrophysiological analysis of a murine model of motoneuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

H reflex restitution and facilitation after different types of peripheral nerve injury and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

Evolution of gait abnormalities in SOD1(G93A) transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

Fragment C of tetanus toxin, more than a carrier. Novel perspectives in non-viral ALS gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

Sera from amyotrophic lateral sclerosis patients induce the non-canonical activation of NMDA receptors "in vitro".

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

Reduction in the motoneuron inhibitory/excitatory synaptic ratio in an early-symptomatic mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

Effect of genetic background on onset and disease progression in the SOD1-G93A model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

Amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13311-012-0140-Y

The localization of the motoneurons supplying the hindlimb muscles of the mouse

21 January 2018

1 reference

12 December 2020

Progressive motor neuron impairment in an animal model of familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man

1 reference

12 December 2020

Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

12 December 2020

Selective loss of alpha motoneurons innervating the medial gastrocnemius muscle in a mouse model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Appearance of phagocytic microglia adjacent to motoneurons in spinal cord tissue from a presymptomatic transgenic rat model of amyotrophic lateral sclerosis

1 reference

12 December 2020

Estimation of nuclear population from microtome sections

1 reference

12 December 2020

Distinct neuroprotective profiles for sigma ligands against N-methyl-D-aspartate (NMDA), and hypoxia-mediated neurotoxicity in neuronal culture toxicity studies

1 reference

12 December 2020

Activation of the sigma receptor 1 suppresses NMDA responses in rat retinal ganglion cells

1 reference

12 December 2020

10.1007/S13311-012-0140-Y

Identifiers

DOI

1 reference

13 August 2017

1 reference

13 August 2017

PubMed publication ID

22935988

1 reference