Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis (Q36330655)

13 August 2017

Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis (English)

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13 August 2017

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John S Munger

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Paul H Weinreb

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Khalid Puthawala

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13 August 2017

Nicos Hadjiangelis

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13 August 2017

Steven C Jacoby

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13 August 2017

Emmanuel Bayongan

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13 August 2017

Zhicheng Zhao

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13 August 2017

Zhiwei Yang

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13 August 2017

Mary Louise Devitt

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13 August 2017

Gerald S Horan

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13 August 2017

Matvey E Lukashev

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13 August 2017

Shelia M Violette

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13 August 2017

Kristen S Grant

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13 August 2017

Cristina Colarossi

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13 August 2017

Silvia C Formenti

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13 August 2017

language of work or name

English

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publication date

4 October 2007

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American Journal of Respiratory and Critical Care Medicine

13 August 2017

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13 August 2017

177

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13 August 2017

82-90

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describes a project that uses

13 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2176115/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse.

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Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury.

30 September 2017

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Prevention of radiation-induced pneumonitis by recombinant adenovirus-mediated transferring of soluble TGF-beta type II receptor gene

30 September 2017

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Profiles of global gene expression in ionizing-radiation-damaged human diploid fibroblasts reveal synchronization behind the G1 checkpoint in a G0-like state of quiescence

30 September 2017

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30 September 2017

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Non-small cell lung cancer therapy-related pulmonary toxicity: an update on radiation pneumonitis and fibrosis

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Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity

30 September 2017

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Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis.

30 September 2017

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Latent TGF-beta binding proteins: extracellular matrix association and roles in TGF-beta activation

30 September 2017

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Integrin alphaVbeta6-mediated activation of latent TGF-beta requires the latent TGF-beta binding protein-1.

30 September 2017

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Smad3 as a mediator of the fibrotic response

30 September 2017

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Disorders of lung matrix remodeling

30 September 2017

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Transforming Growth Factor-β-Dependent and -Independent Pathways of Induction of Tubulointerstitial Fibrosis in β6−/− Mice

30 September 2017

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Making sense of latent TGFbeta activation

30 September 2017

1 reference

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Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

30 September 2017

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The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1

30 September 2017

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The integrin alphaVbeta6 binds and activates latent TGFbeta3.

30 September 2017

1 reference

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TGF-beta is a critical mediator of acute lung injury

30 September 2017

1 reference

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Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology

30 September 2017

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Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis

30 September 2017

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30 September 2017

TGF-beta and fibrosis

1 reference

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The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

30 September 2017

1 reference

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Thrombospondin-1 is a major activator of TGF-beta1 in vivo

30 September 2017

1 reference

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Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung

30 September 2017

1 reference

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Differential regulation of airway epithelial integrins by growth factors

30 September 2017

1 reference

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Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin

30 September 2017

1 reference

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Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells

30 September 2017

1 reference

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Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

30 September 2017

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Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes

30 September 2017

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Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema

29 June 2018

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A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the intermediate and late phases.

29 June 2018

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A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the early phase

29 June 2018

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Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species.

29 June 2018

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TGF-beta concentration specifies differential signaling profiles of growth arrest/differentiation and apoptosis in podocytes.

22 September 2018

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Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis.

22 September 2018

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Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation

22 September 2018

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12 December 2020

All-trans-retinoic acid prevents radiation- or bleomycin-induced pulmonary fibrosis

1 reference

12 December 2020

Universal and radiation-specific loci influence murine susceptibility to radiation-induced pulmonary fibrosis

1 reference

12 December 2020

Plasma TGFβ level in rats after hemithoracic irradiation

1 reference

12 December 2020

Radiation-induced hypoxia may perpetuate late normal tissue injury

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12 December 2020

A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis

1 reference

12 December 2020

A simplified method for the analysis of hydroxyproline in biological tissues

1 reference

12 December 2020

10.1164/RCCM.200706-806OC

Identifiers

DOI

1 reference

13 August 2017

1 reference

13 August 2017

PubMed publication ID

17916808

1 reference