Selective activation of ATF6 and PERK endoplasmic reticulum stress signaling pathways prevent mutant rhodopsin accumulation (Q36327872)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956602%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Selective activation of ATF6 and PERK endoplasmic reticulum stress signaling pathways prevent mutant rhodopsin accumulation (English)

1 reference

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12 February 2020

main subject

endoplasmic reticulum

0 references

1 reference

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12 February 2020

Nobuhiko Hiramatsu

1 reference

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12 February 2020

Carissa Messah

series ordinal

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12 February 2020

Heike Kroeger

series ordinal

1 reference

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12 February 2020

Jonathan H Lin

series ordinal

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12 February 2020

language of work or name

English

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publication date

1 October 2012

1 reference

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Investigative Ophthalmology Visual Science

12 February 2020

published in

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12 February 2020

volume

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12 February 2020

issue

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12 February 2020

page(s)

7159-7166

1 reference

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ER stress in retinal degeneration in S334ter Rho rats

12 February 2020

cites work

1 reference

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IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin

30 September 2017

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The unfolded protein response: from stress pathway to homeostatic regulation

30 September 2017

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Activating transcription factor 6 limits intracellular accumulation of mutant α(1)-antitrypsin Z and mitochondrial damage in hepatoma cells.

30 September 2017

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Monitoring and Manipulating Mammalian Unfolded Protein Response

30 September 2017

1 reference

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Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation

30 September 2017

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Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

30 September 2017

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30 September 2017

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Severe retinal degeneration caused by a novel rhodopsin mutation.

30 September 2017

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Divergent effects of PERK and IRE1 signaling on cell viability

30 September 2017

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Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death

30 September 2017

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Pharmacological manipulation of gain-of-function and dominant-negative mechanisms in rhodopsin retinitis pigmentosa.

30 September 2017

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IRE1 signaling affects cell fate during the unfolded protein response

30 September 2017

1 reference

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Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes.

30 September 2017

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Signal integration in the endoplasmic reticulum unfolded protein response

30 September 2017

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Transport of truncated rhodopsin and its effects on rod function and degeneration

30 September 2017

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Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy

30 September 2017

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Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

30 September 2017

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Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

30 September 2017

1 reference

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

30 September 2017

1 reference

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A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.

30 September 2017

1 reference

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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

30 September 2017

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Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa

30 September 2017

1 reference

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ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

30 September 2017

1 reference

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The cellular fate of mutant rhodopsin: quality control, degradation and aggresome formation.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474590

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

30 September 2017

1 reference

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

30 September 2017

1 reference

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

30 September 2017

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

30 September 2017

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A chemical switch for inhibitor-sensitive alleles of any protein kinase

30 September 2017

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

30 September 2017

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

30 September 2017

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Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

30 September 2017

1 reference

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Retinitis pigmentosa. The Friedenwald Lecture

30 September 2017

1 reference

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High-mannose chains of mammalian glycoproteins

30 September 2017

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Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474590

The relationship of photoreceptor degeneration to retinal vascular development and loss in mutant rhodopsin transgenic and RCS rats

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474590

Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474590

ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474590

Structure and function in rhodopsin. 7. Point mutations associated with autosomal dominant retinitis pigmentosa

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474590

Analysis of Disease-Linked Rhodopsin Mutations Based on Structure, Function, and Protein Stability Calculations

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474590

Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474590

Photoreceptor degeneration in Pro23His and S334ter transgenic rats

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474590

Retinoids assist the cellular folding of the autosomal dominant retinitis pigmentosa opsin mutant P23H.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474590

Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474590

A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474590

The carboxyl-terminal domain is essential for rhodopsin transport in rod photoreceptors

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474590

Characterization of rhodopsin mis-sorting and constitutive activation in a transgenic rat model of retinitis pigmentosa.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474590

Visual field changes in cone-rod degenerations

22 September 2018

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12 December 2020

Optimizing hydrolysis of N-linked high-mannose oligosaccharides by endo-beta-N-acetylglucosaminidase H

1 reference

12 December 2020

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

1 reference

12 December 2020

ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum

1 reference

12 December 2020

A time-dependent phase shift in the mammalian unfolded protein response

1 reference

12 December 2020

Identifiers

DOI

10.1167/IOVS.12-10222

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956602%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956602%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

22956602

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22956602%20AND%20SRC:MED&resulttype=core&format=json