Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions. (Q36300799)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16257830%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

review article

1 reference

title

Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16257830%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

main subject

multiple drug resistance

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16257830%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16257830%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Femke M van de Water

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16257830%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

language of work or name

English

0 references

publication date

1 January 2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16257830%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

published in

Drug Metabolism Reviews

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8 January 2020

volume

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8 January 2020

issue

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8 January 2020

page(s)

443-471

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16257830%20AND%20SRC:MED&resulttype=core&format=json

Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump

8 January 2020

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Steroid hormone receptors and drug discovery: therapeutic opportunities and assay designs

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MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer

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Mutations in ABCC6 cause pseudoxanthoma elasticum

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Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver

21 January 2018

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Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis

21 January 2018

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cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats

21 January 2018

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Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine

21 January 2018

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Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10)

21 January 2018

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Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11)

21 January 2018

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Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats

21 January 2018

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Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats

21 January 2018

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Differential Transactivation by Two Isoforms of the Orphan Nuclear Hormone Receptor CAR

21 January 2018

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Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

21 January 2018

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Dexamethasone modulation of multidrug transporters in normal tissues.

21 January 2018

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Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat.

21 January 2018

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Organ-specific alterations in RAR alpha:RXR alpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis

21 January 2018

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Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver.

21 January 2018

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Enhanced expression of basolateral multidrug resistance protein isoforms Mrp3 and Mrp5 in rat liver by LPS

21 January 2018

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Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

21 January 2018

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Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia

21 January 2018

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Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA

21 January 2018

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Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport

21 January 2018

1 reference

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MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine

21 January 2018

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Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia.

21 January 2018

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Rapid regulation of P-glycoprotein at the blood-brain barrier by endothelin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Analysis of the structure and expression pattern of MRP7 (ABCC10), a new member of the MRP subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Analysis of the drug resistance profile of multidrug resistance protein 7 (ABCC10): resistance to docetaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6).

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530500205275

Influence of cluster formation of acidic phospholipids on decrease in the affinity for ATP of DnaA protein.

21 January 2018

1 reference

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Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects

21 January 2018

1 reference

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ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2

21 January 2018

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The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

cDNA cloning and genomic organization of the murine MRP7, a new ATP-binding cassette transporter

21 January 2018

1 reference

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Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

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Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530500205275

Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Polyspecific organic cation transporters: their functions and interactions with drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

MRP3, an organic anion transporter able to transport anti-cancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

The MRP family of drug efflux pumps

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Regulation of drug and bile salt transporters in liver and intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Analysis of the MRP4 drug resistance profile in transfected NIH3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Demonstration of glutathione-dependent vincristine transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Induction of proteins involved in multidrug resistance (P-glycoprotein, MRP1, MRP2, LRP) and of CYP 3A4 by rifampicin in LLC-PK1 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport-deficient (TR-) rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Impact of drug transporter studies on drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Gender differences in the membrane transport of endogenous and exogenous compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Role of microtubules in estradiol-17beta-D-glucuronide-induced alteration of canalicular Mrp2 localization and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Role of NO in endothelin-regulated drug transport in the renal proximal tubule

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Involvement of guanylyl cyclase and cGMP in the regulation of Mrp2-mediated transport in the proximal tubule

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

A unified nomenclature system for the nuclear receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Increased expression of multidrug resistance-associated protein 1 (mrp1) in hepatocyte basolateral membrane and renal tubular epithelia after bile duct ligation in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Tissue and cell distribution of the multidrug resistance-associated protein (MRP) in mouse intestine and kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Hepatocanalicular organic-anion transport is regulated by protein kinase C

21 January 2018

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Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine.

21 January 2018

1 reference

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Molecular aspects of renal anionic drug transport

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530500205275

MRP6 (ABCC6) detection in normal human tissues and tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Tissue distribution and induction of human multidrug resistant protein 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Characterization of the mouse Abcc12 gene and its transcript encoding an ATP-binding cassette transporter, an orthologue of human ABCC12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Subcellular localization and N-glycosylation of human ABCC6, expressed in MDCKII cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Cellular localization and up-regulation of multidrug resistance-associated protein 3 in hepatocytes and cholangiocytes during obstructive cholestasis in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Regulation of Drug Transporter Gene Expression by Nuclear Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Role of multidrug resistance protein 2 (MRP2) in glutathione-bimane efflux from Caco-2 and rat renal proximal tubule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Effect of dexamethasone treatment on the expression and function of transport proteins in sandwich-cultured rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Molecular cloning and expression of a cyclic AMP-activated chloride conductance regulator: a novel ATP-binding cassette transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Molecular and cellular physiology of renal organic cation and anion transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530500205275

10.1080/03602530500205275

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16257830%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16257830%20AND%20SRC:MED&resulttype=core&format=json