Digitalis: new actions for an old drug (Q36284056)

13 August 2017

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title

Digitalis: new actions for an old drug (English)

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13 August 2017

J Andrew Wasserstrom

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13 August 2017

Gary L Aistrup

series ordinal

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13 August 2017

publication date

1 November 2005

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American Journal of Physiology Heart and Circulatory Physiology

13 August 2017

published in

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13 August 2017

volume

289

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13 August 2017

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13 August 2017

page(s)

H1781-93

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Ouabain- and marinobufagenin-induced proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5.

13 August 2017

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21 January 2018

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A specific binding protein for cardiac glycosides exists in bovine serum.

21 January 2018

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Ouabain augments Ca(2+) transients in arterial smooth muscle without raising cytosolic Na(+).

21 January 2018

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The cellular mechanism of action of cardiotonic steroids: a new hypothesis

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No effect of preoperative selective gut decontamination on endotoxemia and cytokine activation during cardiopulmonary bypass: a randomized, placebo-controlled study

21 January 2018

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Transport and pharmacological properties of nine different human Na, K-ATPase isozymes

21 January 2018

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Effects of chronic excess salt ingestion. Genetic influence on the development of salt hypertension in parabiotic rats: evidence for a humoral factor

21 January 2018

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The alpha2 isoform of Na,K-ATPase mediates ouabain-induced cardiac inotropy in mice

21 January 2018

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Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation.

21 January 2018

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Inhibition of Na/K ATPase From Rat Aorta by Two Na/K Pump Inhibitors, Ouabain and Marinobufagenin Evidence of Interaction With Different α-Subunit Isoforms

21 January 2018

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Marinobufagenin, an endogenous alpha-1 sodium pump ligand, in hypertensive Dahl salt-sensitive rats

21 January 2018

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Coordinated shifts in Na/K-ATPase isoforms and their endogenous ligands during cardiac hypertrophy and failure in NaCl-sensitive hypertension

21 January 2018

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Endogenous ligand of alpha(1) sodium pump, marinobufagenin, is a novel mediator of sodium chloride--dependent hypertension

21 January 2018

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Digitalis arrhythmias: role of oscillatory afterpotentials

21 January 2018

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Marinobufagenin, an endogenous ligand of alpha-1 sodium pump, is a marker of congestive heart failure severity

21 January 2018

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Two functionally different Na/K pumps in cardiac ventricular myocytes

21 January 2018

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Isoform-specific stimulation of cardiac Na/K pumps by nanomolar concentrations of glycosides

21 January 2018

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Subunit assembly and functional maturation of Na,K-ATPase

21 January 2018

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Src-mediated inter-receptor cross-talk between the Na+/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases

21 January 2018

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Positive inotropic effects of the endogenous Na+/K(+)-transporting ATPase inhibitor from the hypothalamus

21 January 2018

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Identification and characterization of a ouabain-like compound from human plasma

21 January 2018

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Observations on the nature, biosynthesis, secretion and significance of endogenous ouabain

21 January 2018

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No evidence for a role in signal‐transduction of Na+/K+‐ATPase interaction with putative endogenous ouabain

21 January 2018

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21 January 2018

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Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Distinct distribution of different Na+ pump alpha subunit isoforms in plasmalemma. Physiological implications

21 January 2018

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Na+ pump low and high ouabain affinity alpha subunit isoforms are differently distributed in cells

21 January 2018

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Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres

21 January 2018

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Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases

21 January 2018

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Purification and characterization of ouabain-binding protein in human plasma

21 January 2018

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The brain and salt-sensitive hypertension

21 January 2018

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A role for sodium/calcium exchange in the action potential shortening caused by strophanthidin in guinea pig ventricular myocytes

21 January 2018

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The cellular actions of digitalis glycosides on the heart.

21 January 2018

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Circulating bufodienolide and cardenolide sodium pump inhibitors in preeclampsia.

21 January 2018

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Structure-activity relationships for the hypertensinogenic activity of ouabain: role of the sugar and lactone ring

21 January 2018

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Plasma ouabain-like factor during acute and chronic changes in sodium balance in essential hypertension.

21 January 2018

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Effects of intracellular calcium injection on steady state membrane currents in isolated single ventricular cells

21 January 2018

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Effect of R56865 on cardiac sarcoplasmic reticulum function and its role as an antagonist of digoxin at the sarcoplasmic reticulum calcium release channel.

21 January 2018

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Digoxin activates sarcoplasmic reticulum Ca(2+)-release channels: a possible role in cardiac inotropy.

21 January 2018

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Cell signaling microdomain with Na,K-ATPase and inositol 1,4,5-trisphosphate receptor generates calcium oscillations

21 January 2018

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Inhibition of Na-K pump current in guinea pig ventricular myocytes by dihydroouabain occurs at high- and low-affinity sites

21 January 2018

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Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2

21 January 2018

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Positive inotropic effect of ouabain on isolated heart is accompanied by activation of signal pathways that link Na+/K+-ATPase to ERK1/2.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Use of flexible polymers as probes of glomerular pore size

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Positive inotropic effects of ouabain in isolated cat ventricular myocytes in sodium-free conditions

21 January 2018

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Mechanism of action of therapeutic levels of cardiac glycosides

21 January 2018

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Ouabain binding kinetics of the rat alpha two and alpha three isoforms of the sodium-potassium adenosine triphosphate

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Determination of bufalin-like immunoreactivity in serum of humans and rats by time-resolved fluoroimmunoassay for using a monoclonal antibody

21 January 2018

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Partial inhibition of Na+/K+-ATPase by ouabain induces the Ca2+-dependent expressions of early-response genes in cardiac myocytes.

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Structure-function relationships in the Na,K-ATPase alpha subunit: site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Effect of green tea extract on cardiac hypertrophy following 5/6 nephrectomy in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Effect of cardiac glycosides on action potential characteristics and contractility in cat ventricular myocytes: role of calcium overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Activation of cardiac ryanodine receptors by cardiac glycosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Endogenous cardiac glycosides, a new class of steroid hormones

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Substitution of transmembrane residues with hydrogen-bonding potential in the .alpha. subunit of sodium-potassium ATPase reveals alterations in ouabain sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

The Na, K-ATPase in the failing human heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Distribution of proteins implicated in excitation-contraction coupling in rat ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Characterisation of Na/K-ATPase, its isoforms, and the inotropic response to ouabain in isolated failing human hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Pulse pressure correlates in humans with a proscillaridin A immunoreactive compound

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Immunologic identification of Na+,K(+)-ATPase isoforms in myocardium. Isoform change in deoxycorticosterone acetate-salt hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Sodium pump isoform specificity for the digitalis-like factor isolated from human peritoneal dialysate

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

The T-cell suppressive effect of bufadienolides: structural requirements for their immunoregulatory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Localization and function of the Na+/Ca2+-exchanger in normal and detubulated rat cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Involvement of mitogen-activated protein kinases and reactive oxygen species in the inotropic action of ouabain on cardiac myocytes. A potential role for mitochondrial K(ATP) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Sodium-calcium exchange in mammalian heart: current-voltage relation and intracellular calcium concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Na+-Ca2+ exchange activity is localized in the T-tubules of rat ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

High-affinity ouabain binding site and low-dose positive inotropic effect in rat myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

Coupling of the Na+/Ca2+exchanger, Na+/K+ pump and sarcoplasmic reticulum in smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00707.2004

10.1152/AJPHEART.00707.2004

21 January 2018

Identifiers

DOI

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13 August 2017

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