Wilms' tumour: connecting tumorigenesis and organ development in the kidney (Q36234726)

12 August 2017

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title

Wilms' tumour: connecting tumorigenesis and organ development in the kidney (English)

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12 August 2017

Miguel N Rivera

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12 August 2017

Daniel A Haber

series ordinal

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12 August 2017

language of work or name

English

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publication date

1 September 2005

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12 August 2017

published in

Nature Reviews Cancer

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12 August 2017

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12 August 2017

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12 August 2017

page(s)

699-712

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Recent advances in Wilms tumor genetics

12 August 2017

cites work

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Relaxation of imprinted genes in human cancer.

21 January 2018

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Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

21 January 2018

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Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

21 January 2018

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An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor

21 January 2018

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The candidate Wilms' tumour gene is involved in genitourinary development

21 January 2018

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WT-1 is required for early kidney development

21 January 2018

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Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome

21 January 2018

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Donor splice-site mutations in WT1 are responsible for Frasier syndrome

21 January 2018

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Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms.

21 January 2018

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Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome

21 January 2018

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Identical Genetic Changes in Different Histologic Components of Wilms' Tumors

21 January 2018

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Microdissecting the genetic events in nephrogenic rests and Wilms' tumor development

21 January 2018

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Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition

21 January 2018

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Transcript profiling of Wilms tumors reveals connections to kidney morphogenesis and expression patterns associated with anaplasia.

21 January 2018

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WNT and beta-catenin signalling: diseases and therapies

21 January 2018

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Glypican-3 modulates BMP- and FGF-mediated effects during renal branching morphogenesis

21 January 2018

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WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour

21 January 2018

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Evidence for a familial Wilms' tumour gene (FWT1) on chromosome 17q12–q21

21 January 2018

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Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndrome

21 January 2018

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An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome

21 January 2018

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Loss of heterozygosity for the short arm of chromosome 7 in sporadic Wilms tumour.

21 January 2018

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Gain of 1q is associated with adverse outcome in favorable histology Wilms' tumors

21 January 2018

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Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region

21 January 2018

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A mammal-specific exon of WT1 is not required for development or fertility

21 January 2018

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Internal translation initiation generates novel WT1 protein isoforms with distinct biological properties

21 January 2018

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Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histology

21 January 2018

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The Wilms tumour gene WT1 is expressed in murine mesoderm-derived tissues and mutated in a human mesothelioma

21 January 2018

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Wilms' tumour gene 1 (WT1) in human neoplasia.

21 January 2018

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A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization

21 January 2018

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DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1

21 January 2018

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Sequence and structural requirements for high-affinity DNA binding by the WT1 gene product

21 January 2018

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A functional interaction with CBP contributes to transcriptional activation by the Wilms tumor suppressor WT1.

21 January 2018

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Physical interaction between Wilms tumor 1 and p73 proteins modulates their functions.

21 January 2018

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A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1

21 January 2018

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Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1

21 January 2018

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Anlaysis of complementary expression profiles following WT1 induction versus repression reveals the cholesterol/fatty acid synthetic pathways as a possible major target of WT1.

21 January 2018

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Tumor-associated WT1 missense mutants indicate that transcriptional activation by WT1 is critical for growth control

21 January 2018

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WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene

21 January 2018

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The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin

21 January 2018

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E-cadherin is a WT1 target gene

21 January 2018

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The receptor tyrosine kinase regulator Sprouty1 is a target of the tumor suppressor WT1 and important for kidney development

21 January 2018

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WT1 regulates the expression of the major glomerular podocyte membrane protein Podocalyxin

21 January 2018

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The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1.

21 January 2018

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The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1.

21 January 2018

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The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation

21 January 2018

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The Wilms' tumor gene Wt1 is required for normal development of the retina

21 January 2018

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Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

21 January 2018

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Presence of WT1, the Wilm's tumor suppressor gene product, in nuclear poly(A)(+) ribonucleoprotein

21 January 2018

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Identification of WTAP, a novel Wilms' tumour 1-associating protein

21 January 2018

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RNA binding by the Wilms tumor suppressor zinc finger proteins.

21 January 2018

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Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation

21 January 2018

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WT1 proteins: functions in growth and differentiation

21 January 2018

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21 January 2018

The complex life of WT1

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21 January 2018

inferred from DOI database lookup

7 January 2021

based on heuristic

Wilms tumor and the WT1 gene

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Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud

21 January 2018

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Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction

21 January 2018

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The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo.

21 January 2018

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YAC transgenic analysis reveals Wilms' tumour 1 gene activity in the proliferating coelomic epithelium, developing diaphragm and limb.

21 January 2018

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The Wilms tumor suppressor gene wt1 is required for development of the spleen.

21 January 2018

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WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis

21 January 2018

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A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome

21 January 2018

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A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development

21 January 2018

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Murine Denys-Drash syndrome: evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis

21 January 2018

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WT1 expression induces features of renal epithelial differentiation in mesenchymal fibroblasts

21 January 2018

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The Wilms tumor suppressor WT1 directs stage-specific quiescence and differentiation of human hematopoietic progenitor cells

21 January 2018

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Role of the WT1 tumor suppressor in murine hematopoiesis

21 January 2018

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Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation.

21 January 2018

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Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

21 January 2018

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Transcriptional regulation of IGF-I receptor gene expression by novel isoforms of the EWS-WT1 fusion protein

21 January 2018

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Induction of the interleukin-2/15 receptor beta-chain by the EWS-WT1 translocation product.

21 January 2018

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Induction of BAIAP3 by the EWS-WT1 chimeric fusion implicates regulated exocytosis in tumorigenesis.

21 January 2018

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Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein

21 January 2018

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Upregulation of c-MYC in WT1-mutant tumors: assessment of WT1 putative transcriptional targets using cDNA microarray expression profiling of genetically defined Wilms' tumors

21 January 2018

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CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors

21 January 2018

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Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

21 January 2018

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Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1.

21 January 2018

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Wnt-6 is expressed in the ureter bud and induces kidney tubule development in vitro

21 January 2018

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Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development.

21 January 2018

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Uniparental paternal disomy in a genetic cancer-predisposing syndrome

21 January 2018

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The history of cancer epigenetics

21 January 2018

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A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

21 January 2018

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Parental imprinting of the mouse H19 gene

21 January 2018

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Monoallelic expression of the human H19 gene

21 January 2018

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Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome

21 January 2018

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Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15

21 January 2018

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Loss of imprinting of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith-Wiedemann syndrome and is independent of insulin-like growth factor II imprinting

21 January 2018

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A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome

21 January 2018

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Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects

21 January 2018

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Coordinating early kidney development: lessons from gene targeting

21 January 2018

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Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome

21 January 2018

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Cell surface glypicans are low-affinity endostatin receptors

21 January 2018

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Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud.

21 January 2018

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Recent genetic studies of mouse kidney development

21 January 2018

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Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia

21 January 2018

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Renal and neuronal abnormalities in mice lacking GDNF

21 January 2018

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Defects in enteric innervation and kidney development in mice lacking GDNF

21 January 2018

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Renal agenesis and the absence of enteric neurons in mice lacking GDNF

21 January 2018

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Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

21 January 2018

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Haploinsufficiency of NSD1 causes Sotos syndrome

21 January 2018

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Clonality and loss of heterozygosity of WT genes are early events in the pathogenesis of nephroblastomas

21 January 2018

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Infrequent mutation of theWT1 gene in 77 Wilms' tumors

21 January 2018

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Loss of heterozygosity at chromosome 11p15 in Wilms tumors: identification of two independent regions

21 January 2018

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Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour

21 January 2018

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Tumour-suppressor activity of H19 RNA

21 January 2018

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21 January 2018

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Nephrogenic rests, nephroblastomatosis, and the pathogenesis of Wilms' tumor

31 March 2020

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Wilms tumor locus on 11p13 defined by multiple CpG island-associated transcripts

31 March 2020

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Tissue, developmental, and tumor-specific expression of divergent transcripts in Wilms tumor

31 March 2020

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Expression of the Wilms' tumor gene WT1 in the murine urogenital system

31 March 2020

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ASSOCIATION OF WILMS'S TUMOR WITH ANIRIDIA, HEMIHYPERTROPHY AND OTHER CONGENITAL MALFORMATIONS

31 March 2020

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Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour

31 March 2020

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Mutation and cancer: statistical study of retinoblastoma

31 March 2020

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IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedemann syndrome

31 March 2020

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Fine structure analysis of the WT1 gene in sporadic Wilms tumors

31 March 2020

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Loss of Imprinting of Insulin-Like Growth Factor-II (IGF2) Gene in Distinguishing Specific Biologic Subtypes of Wilms Tumor

31 March 2020

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Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations

31 March 2020

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A gene expression signature for relapse of primary wilms tumors

31 March 2020

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Chromosome 1q expression profiling and relapse in Wilms' tumour

31 March 2020

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Aniridia-Wilms’ tumor association: evidence for specific deletion of 11p13

31 March 2020

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Alternative splicing and genomic structure of the Wilms tumor gene WT1

31 March 2020

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Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence

31 March 2020

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A non-AUG translational initiation event generates novel WT1 isoforms

31 March 2020

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RNA editing in the Wilms' tumor susceptibility gene, WT1

31 March 2020

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WT1 mutations associated with incomplete Denys-Drash syndrome define a domain predicted to behave in a dominant-negative fashion

31 March 2020

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Evidence that WT1 mutations in Denys — Drash syndrome patients may act in a dominant-negative fashion

31 March 2020

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Loss of WT1 function leads to ectopic myogenesis in Wilms' tumour

31 March 2020

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New developments in the pathology of Wilms tumor

31 March 2020

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A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1

31 March 2020

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WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis

31 March 2020

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Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70

31 March 2020

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Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain

31 March 2020

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SUMO-1 modification of the Wilms' tumor suppressor WT1

31 March 2020

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The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis

31 March 2020

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Physical and functional interaction between WT1 and p53 proteins

31 March 2020

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Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9

31 March 2020

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WT1 activates a glomerular-specific enhancer identified from the human nephrin gene

31 March 2020

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Truncated WT1 mutants alter the subnuclear localization of the wild-type protein

31 March 2020

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WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes

31 March 2020

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G1 phase arrest induced by Wilms tumor protein WT1 is abrogated by cyclin/CDK complexes

31 March 2020

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A rodent model for Wilms tumors: embryonal kidney neoplasms induced by N-nitroso-N'-methylurea

31 March 2020

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Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): desmoplastic small round-cell tumor and its variants

31 March 2020

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Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor

31 March 2020

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The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour

31 March 2020

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Abnormality of chromosome 11 in patients with features of Beckwith-Wiedemann syndrome

31 March 2020

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Chromosome 11 uniparental isodisomy predisposing to embryonal neoplasms

31 March 2020

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Molecular nature of genetic changes resulting in loss of heterozygosity of chromosome 11 in Wilms' tumours

31 March 2020

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Parental genomic imprinting of the human IGF2 gene

31 March 2020

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Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith–Wiedemann and Simpson–Golabi–Behmel syndromes

31 March 2020

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Epigenetic lesions at the H19 locus in Wilms' tumour patients

31 March 2020

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Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour

31 March 2020

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Parental imprinting of human chromosome region 11p15.3-pter involved in the Beckwith-Wiedemann syndrome and various human neoplasia

31 March 2020

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Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung

31 March 2020

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Clinical and molecular aspects of the Simpson-Golabi-Behmel syndrome

31 March 2020

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The Simpson-Golabi-Behmel gene, GPC3, is not involved in sporadic Wilms tumorigenesis

31 March 2020

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A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye

31 March 2020

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Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1696

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Dimensions Publication ID

12 August 2017

1034028024

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