TLK-286: a novel glutathione S-transferase-activated prodrug (Q36210931)

12 August 2017

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title

TLK-286: a novel glutathione S-transferase-activated prodrug (English)

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12 August 2017

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Kenneth D Tew

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12 August 2017

language of work or name

English

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publication date

1 August 2005

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Expert Opinion on Investigational Drugs

12 August 2017

published in

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12 August 2017

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12 August 2017

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12 August 2017

page(s)

1047-1054

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Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

12 August 2017

cites work

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The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance

21 January 2018

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Structure, catalytic mechanism, and evolution of the glutathione transferases

21 January 2018

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Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus

21 January 2018

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Glutathione-S-transferase activates novel alkylating agents

21 January 2018

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Synthesis, activation, and cytotoxicity of aldophosphamide analogues.

21 January 2018

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Three models of free radical-induced cell injury

21 January 2018

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Increased myeloproliferation in glutathione S-transferase pi-deficient mice is associated with a deregulation of JNK and Janus kinase/STAT pathways

21 January 2018

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The structure of the human glutathione S-transferase pi gene

21 January 2018

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Overexpression of glutathione S-transferase pi enhances the adduct formation of cisplatin with glutathione in human cancer cells

21 January 2018

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Association between glutathione S-transferase P1, T1, and M1 genetic polymorphism and survival of patients with metastatic colorectal cancer

21 January 2018

1 reference

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The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells.

21 January 2018

1 reference

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Multi-institutional phase 2 study of TLK286 (TELCYTA, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer

21 January 2018

1 reference

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10.1517/13543784.14.8.1047

21 January 2018

Identifiers

DOI

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12 August 2017

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