In vivo information-guided prediction approach for assessing the risks of drug-drug interactions associated with circulating inhibitory metabolites (Q36105348)

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English	In vivo information-guided prediction approach for assessing the risks of drug-drug interactions associated with circulating inhibitory metabolites	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

In vivo information-guided prediction approach for assessing the risks of drug-drug interactions associated with circulating inhibitory metabolites (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

drug interaction

0 references

author name string

Zhe-Yi Hu

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Robert B Parker

2

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

S Casey Laizure

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

publication date

4 May 2012

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Drug Metabolism and Disposition

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

40

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

1487-1494

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Warfarin-amiodarone drug-drug interactions: determination of [I](u)/K(I,u) for amiodarone and its plasma metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

2 October 2017

Quantitative Prediction of Cytochrome P450 (CYP) 2D6-Mediated Drug Interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

2 October 2017

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

2 October 2017

Are Circulating Metabolites Important in Drug–Drug Interactions?: Quantitative Analysis of Risk Prediction and Inhibitory Potency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

2 October 2017

Effect of single and repeat doses of casopitant on the pharmacokinetics of CYP450 3A4 substrates midazolam and nifedipine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

2 October 2017

Prediction of pharmacokinetic drug-drug interaction caused by changes in cytochrome P450 activity using in vivo information

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

2 October 2017

Predicting drug-drug interactions from in vitro drug metabolism data: challenges and recent advances

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

2 October 2017

General framework for the quantitative prediction of CYP3A4-mediated oral drug interactions based on the AUC increase by coadministration of standard drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

2 October 2017

Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

2 October 2017

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

2 October 2017

Prediction of pharmacokinetics and drug-drug interactions from in vitro metabolism data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

2 October 2017

Dose of midazolam should be reduced during diltiazem and verapamil treatments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

2 October 2017

Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

2 July 2018

Comparative effects of the diastereoisomers, quinine and quinidine in producing phenocopy debrisoquine poor metabolisers (PMs) in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

2 July 2018

Utilizing drug-drug interaction prediction tools during drug development: enhanced decision making based on clinical risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

23 September 2018

Perpetrators of pharmacokinetic drug-drug interactions arising from altered cytochrome P450 activity: a criteria-based assessment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

23 September 2018

Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

23 September 2018

Prediction of the effect of erythromycin, diltiazem, and their metabolites, alone and in combination, on CYP3A4 inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

23 September 2018

An in vitro mechanistic study to elucidate the desipramine/bupropion clinical drug-drug interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

23 September 2018

Studies to investigate the pharmacokinetic interactions between ranolazine and ketoconazole, diltiazem, or simvastatin during combined administration in healthy subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

23 September 2018

Effect of venlafaxine on imipramine metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

23 September 2018

The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

23 September 2018

Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

23 September 2018

Influence of the antibiotics erythromycin and azithromycin on the pharmacokinetics and pharmacodynamics of midazolam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

23 September 2018

The effects of the systemic antimycotics, itraconazole and fluconazole, on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

23 September 2018

A potentially hazardous interaction between erythromycin and midazolam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400792

23 September 2018

Stereoselective interaction of sulfinpyrazone with racemic warfarin and its separated enantiomorphs in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The warfarin-sulfinpyrazone interaction: stereochemical considerations

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic interaction between intravenous phenytoin and amiodarone in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of desipramine coadministered with sertraline or fluoxetine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Desipramine Pharmacokinetics When Coadministered With Paroxetine or Sertraline in Extensive Metabolizers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of sertraline on the pharmacokinetics of desipramine and imipramine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intestinal and Hepatic Metabolic Activity of Five Cytochrome P450 Enzymes: Impact on Prediction of First-Pass Metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of different approaches to predict metabolic drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential role of intestinal first-pass metabolism in the prediction of drug–drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563046

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/DMD.112.045799

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

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