Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. II. RSU 1069 (Q36080498)

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English	Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. II. RSU 1069	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. II. RSU 1069 (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

0 references

author name string

P L Olive

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

language of work or name

0 references

publication date

1 March 1995

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

British Journal of Cancer

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

71

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

537-542

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: with particular reference to in vivo methods of evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033631

2 October 2017

Oxygen in human tumors: correlations between methods of measurement and response to therapy. Summary of a workshop held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033631

2 October 2017

Intermittent blood flow in a murine tumor: radiobiological effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033631

2 October 2017

Studies of the in vivo and in vitro cytotoxicity of the drug RSU-1069.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033631

2 October 2017

The differential cytotoxicity of RSU 1069: cell survival studies indicating interaction with DNA as a possible mode of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033631

2 October 2017

Cell selection from a murine tumour using the fluorescent probe Hoechst 33342

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033631

2 October 2017

Induction and rejoining of radiation-induced DNA single-strand breaks: “tail moment” as a function of position in the cell cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033631

11 July 2018

Pharmacology of the mixed-function radio- and chemosensitizers CB 1954 and RSU 1069.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033631

11 July 2018

Induction of DNA strand breaks by RSU-1069, a nitroimidazole-aziridine radiosensitizer. Role of binding of both unreduced and radiation-reduced forms to DNA, in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033631

11 July 2018

A comparison of the techniques of alkaline filter elution and alkaline sucrose sedimentation used to assess DNA damage induced by 2-nitroimidazoles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033631

11 July 2018

Pharmacologic/pharmacokinetic evaluation of emesis induced by analogs of RSU 1069 and its control by antiemetic agents.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033631

11 July 2018

Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033631

23 September 2018

Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033631

23 September 2018

Toxicity of RSU-1069 for KHT cells treated in vivo or in vitro: evidence for a diffusible toxic product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2033631

23 September 2018

Detection of hypoxic cells in a murine tumor with the use of the comet assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of bioreductive drugs in multicell spheroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation-induced reoxygenation in the SCCVII murine tumour: evidence for a decrease in oxygen consumption and an increase in tumour perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RSU 1069, a nitroimidazole containing an aziridine group. Bioreduction greatly increases cytotoxicity under hypoxic conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the toxicity of RSU-1069

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of DNA crosslinks in vitro upon reduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxicity of RSU 1069 in spheroids and murine tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetic contribution to the improved therapeutic selectivity of a novel bromoethylamino prodrug (RB 6145) of the mixed-function hypoxic cell sensitizer/cytotoxin ?-(1-aziridinomethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069)

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908)

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/7880736

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/BJC.1995.106

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

0 references

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