cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells (Q35983493)

11 August 2017

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells (English)

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11 August 2017

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11 August 2017

Marius Döring

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Tobias Schmidt

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Ulrich Kalinke

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Veit Hornung

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11 August 2017

Jennifer Paijo

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11 August 2017

Julia Spanier

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11 August 2017

Elena Grabski

1 reference

11 August 2017

Mohammed Nooruzzaman

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11 August 2017

Gregor Witte

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11 August 2017

Volkhard Kaever

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11 August 2017

8 April 2016

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11 August 2017

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11 August 2017

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11 August 2017

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11 August 2017

e1005546

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Creative Commons Attribution 4.0 International

11 August 2017

start time

8 April 2016

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April 2022 Public Data File from Crossref

copyrighted

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2 October 2017

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Alveolar Macrophages Isolated Directly From Human Cytomegalovirus (HCMV)-Seropositive Individuals Are Sites of HCMV Reactivation In Vivo

2 October 2017

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Cytosolic RNA:DNA hybrids activate the cGAS-STING axis

2 October 2017

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Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway

2 October 2017

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Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses

2 October 2017

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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

2 October 2017

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Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion

2 October 2017

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Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

2 October 2017

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A peptide inhibitor of cytomegalovirus infection from human hemofiltrate

2 October 2017

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Structural mechanism of cytosolic DNA sensing by cGAS

2 October 2017

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cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

2 October 2017

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The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

2 October 2017

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Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors

2 October 2017

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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

2 October 2017

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Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

2 October 2017

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Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans

2 October 2017

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IFN-α subtypes: distinct biological activities in anti-viral therapy.

2 October 2017

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The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication

2 October 2017

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Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency

2 October 2017

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IFI16 is an innate immune sensor for intracellular DNA

2 October 2017

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Modulation of host innate and adaptive immune defenses by cytomegalovirus: timing is everything

2 October 2017

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Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1.

2 October 2017

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

2 October 2017

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Human cytomegalovirus suppresses type I interferon secretion by plasmacytoid dendritic cells through its interleukin 10 homolog.

2 October 2017

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Human cytomegalovirus interferes with signal transducer and activator of transcription (STAT) 2 protein stability and tyrosine phosphorylation

2 October 2017

1 reference

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

2 October 2017

1 reference

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Lymphotoxin-mediated crosstalk between B cells and splenic stroma promotes the initial type I interferon response to cytomegalovirus

2 October 2017

1 reference

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DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825940

Essential role of IPS-1 in innate immune responses against RNA viruses

2 October 2017

1 reference

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A human cytomegalovirus antagonist of type I IFN-dependent signal transducer and activator of transcription signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825940

Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825940

Major human cytomegalovirus structural protein pp65 (ppUL83) prevents interferon response factor 3 activation in the interferon response

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825940

Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome

2 October 2017

1 reference

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Human cytomegalovirus inhibits cytokine-induced macrophage differentiation

2 October 2017

1 reference

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Human cytomegalovirus induces monocyte differentiation and migration as a strategy for dissemination and persistence

2 October 2017

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VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents

2 October 2017

1 reference

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Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/beta

2 October 2017

1 reference

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Ability of the matrix protein of vesicular stomatitis virus to suppress beta interferon gene expression is genetically correlated with the inhibition of host RNA and protein synthesis

2 October 2017

1 reference

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Diagnosis and management of human cytomegalovirus infection in the mother, fetus, and newborn infant

2 October 2017

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Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo

2 October 2017

1 reference

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Reactivation of latent human cytomegalovirus in CD14(+) monocytes is differentiation dependent

2 October 2017

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Biologic consequences of Stat1-independent IFN signaling.

2 October 2017

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A Toll-like receptor recognizes bacterial DNA

2 October 2017

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The nature of the principal type 1 interferon-producing cells in human blood

2 October 2017

1 reference

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Interferon gamma regulates acute and latent murine cytomegalovirus infection and chronic disease of the great vessels

2 October 2017

1 reference

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Structure of the human type-I interferon gene cluster determined from a YAC clone contig

2 October 2017

1 reference

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M27 expressed by cytomegalovirus counteracts effective type I interferon induction of myeloid cells but not of plasmacytoid dendritic cells

2 October 2017

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Concomitant TLR/RLH signaling of radioresistant and radiosensitive cells is essential for protection against vesicular stomatitis virus infection

11 July 2018

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Independent of plasmacytoid dendritic cell (pDC) infection, pDC triggered by virus-infected cells mount enhanced type I IFN responses of different composition as opposed to pDC stimulated with free virus

11 July 2018

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Self-priming determines high type I IFN production by plasmacytoid dendritic cells

11 July 2018

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Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling

11 July 2018

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Human cytomegalovirus infection of M1 and M2 macrophages triggers inflammation and autologous T-cell proliferation.

11 July 2018

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A cytomegaloviral protein reveals a dual role for STAT2 in IFN-{gamma} signaling and antiviral responses

11 July 2018

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Human cytomegalovirus immediate-early 2 gene expression blocks virus-induced beta interferon production

11 July 2018

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Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells

11 July 2018

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Fusion-active glycoprotein G mediates the cytotoxicity of vesicular stomatitis virus M mutants lacking host shut-off activity

11 July 2018

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Cloning and sequencing of a highly productive, endotheliotropic virus strain derived from human cytomegalovirus TB40/E.

24 September 2018

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Immune evasion by cytomegalovirus--survival strategies of a highly adapted opportunist.

24 September 2018

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Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology

24 September 2018

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TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

21 January 2018

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Natural killer cell-mediated response to human cytomegalovirus-infected macrophages is modulated by their functional polarization

21 January 2018

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Tissue macrophages are infected by human cytomegalovirus in vivo

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12 December 2020

MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo

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12 December 2020

CD11c+ dendritic cells and plasmacytoid DCs are activated by human cytomegalovirus and retain efficient T cell-stimulatory capability upon infection

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12 December 2020

Latency and reactivation of human cytomegalovirus

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12 December 2020

Human cytomegalovirus differentially controls B cell and T cell responses through effects on plasmacytoid dendritic cells

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12 December 2020

Erratum: Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

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12 December 2020

Monocyte-derived dendritic cells are permissive to the complete replicative cycle of human cytomegalovirus

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12 December 2020

10.1371/JOURNAL.PPAT.1005546

Identifiers

DOI

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

27058035

1 reference