Molecular genetics and genomics of heart failure (Q35936390)

11 August 2017

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title

Molecular genetics and genomics of heart failure (English)

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11 August 2017

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Choong-Chin Liew

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11 August 2017

Victor J Dzau

series ordinal

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11 August 2017

publication date

1 November 2004

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11 August 2017

published in

Nature Reviews Genetics

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11 August 2017

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11 August 2017

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11 August 2017

page(s)

811-825

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Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population

11 August 2017

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Autoantibodies activating human beta1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure.

21 January 2018

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Transcriptomal analysis of failing and nonfailing human hearts.

21 January 2018

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Sex dependence and temporal dependence of the left ventricular genomic response to pressure overload

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Differential myocardial gene expression in the development and rescue of murine heart failure

21 January 2018

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Alterations in apoptotic signaling in human idiopathic cardiomyopathic hearts in failure

21 January 2018

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Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray

21 January 2018

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Cardiac intracellular calcium release channels: role in heart failure

21 January 2018

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Microarray gene expression profiles in dilated and hypertrophic cardiomyopathic end-stage heart failure

21 January 2018

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Profiling gene transcription reveals a deficiency of mitochondrial oxidative phosphorylation in Trypanosoma cruzi-infected murine hearts: implications in chagasic myocarditis development

21 January 2018

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Molecular mechanisms of reduced beta-adrenergic signaling in the aged heart as revealed by genomic profiling

21 January 2018

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Alterations of gene expression in failing myocardium following left ventricular assist device support

21 January 2018

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Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract

21 January 2018

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Increased expression of cytoskeletal, linkage, and extracellular proteins in failing human myocardium

21 January 2018

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Reperfusion causes significant activation of heat shock transcription factor 1 in ischemic rat heart

21 January 2018

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Economics of chronic heart failure.

21 January 2018

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Update on therapy for heart failure

31 March 2020

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Epidemiology of heart failure

31 March 2020

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New epidemiologic perspectives concerning mild-to-moderate heart failure

31 March 2020

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Diastolic heart failure--abnormalities in active relaxation and passive stiffness of the left ventricle

31 March 2020

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Diagnosis and outpatient management of congestive heart failure

31 March 2020

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Genetic aspects of arrhythmias

31 March 2020

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31 March 2020

Heart failure in women

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Calcium cycling in congestive heart failure

31 March 2020

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Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure

31 March 2020

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Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure

31 March 2020

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Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function.

31 March 2020

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Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban

31 March 2020

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Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

31 March 2020

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PKC-alpha regulates cardiac contractility and propensity toward heart failure

31 March 2020

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Calstabin deficiency, ryanodine receptors, and sudden cardiac death

31 March 2020

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A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

31 March 2020

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Decoding calcium signals involved in cardiac growth and function

31 March 2020

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Control of cardiac growth and function by calcineurin signaling

31 March 2020

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CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo

31 March 2020

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Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo

31 March 2020

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Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.

31 March 2020

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Endothelial nitric oxide synthase overexpression attenuates congestive heart failure in mice

31 March 2020

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Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms

31 March 2020

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Differential expression of tissue inhibitors of metalloproteinases in the failing human heart

31 March 2020

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Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction

31 March 2020

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Activation of matrix metalloproteinases in the failing human heart: breaking the tie that binds

31 March 2020

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Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro

31 March 2020

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X-linked dilated cardiomyopathy. Molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus

31 March 2020

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Cardiomyopathic features associated with muscular dystrophy are independent of dystrophin absence in cardiovasculature

31 March 2020

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The heart in human dystrophinopathies

31 March 2020

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Mutations in the human delta-sarcoglycan gene in familial and sporadic dilated cardiomyopathy

31 March 2020

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β–sarcoglycan: characterization and role in limb–girdle muscular dystrophy linked to 4q12

31 March 2020

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Disruption of heart sarcoglycan complex and severe cardiomyopathy caused by beta sarcoglycan mutations

31 March 2020

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Decrease in sarcoglycans and dystrophin in failing heart following acute myocardial infarction

31 March 2020

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Intermediate filaments and the function of the dystrophin-protein complex

31 March 2020

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Heart-specific localization of emerin: new insights into Emery-Dreifuss muscular dystrophy

31 March 2020

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Sensing stretch is fundamental

31 March 2020

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The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy

31 March 2020

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Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload

31 March 2020

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Consequences of pressure overload on sarcomere protein mutation-induced hypertrophic cardiomyopathy.

31 March 2020

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The Genetic Basis for Cardiomyopathy

31 March 2020

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The Sympathetic Nervous System and the Renin–Angiotensin–Aldosterone System in Cardiovascular Disease

31 March 2020

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Direct actions of urotensin II on the heart: implications for cardiac fibrosis and hypertrophy

31 March 2020

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Congestive heart failure and expression of myocardial urotensin II.

31 March 2020

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beta-Blocker therapy in heart failure: scientific review

31 March 2020

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Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure

31 March 2020

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A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor

31 March 2020

1 reference

Manipulating cardiac contractility in heart failure: data from mice and men.

31 March 2020

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Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level

31 March 2020

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Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.

31 March 2020

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Recent insights into the role of tumor necrosis factor in the failing heart.

31 March 2020

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Tumor necrosis factor-alpha and tumor necrosis factor receptors in the failing human heart

31 March 2020

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Myoglobin protects the heart from inducible nitric-oxide synthase (iNOS)-mediated nitrosative stress

31 March 2020

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Big endothelin in chronic heart failure: marker of disease severity or genetic determination?

31 March 2020

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An in situ quantitative immunohistochemical study of cytokines and IL-2R+ in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens

31 March 2020

1 reference

Effect of chagasic sera on the rat isolated atrial preparation: immunological, morphological and function aspects

31 March 2020

1 reference

Autoantibodies against beta-adrenoceptors in human idiopathic dilated cardiomyopathy

31 March 2020

1 reference

Circulating cardiac autoantibodies in dilated cardiomyopathy and myocarditis: pathogenetic and clinical significance.

31 March 2020

1 reference

Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy

31 March 2020

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Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

31 March 2020

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Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity

31 March 2020

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Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents

31 March 2020

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Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors

31 March 2020

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A decade of discoveries in cardiac biology

31 March 2020

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Apoptosis in heart: basic mechanisms and implications in cardiovascular diseases

31 March 2020

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A mechanistic role for cardiac myocyte apoptosis in heart failure

31 March 2020

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Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms

31 March 2020

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Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis

31 March 2020

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ErbB2 is essential in the prevention of dilated cardiomyopathy.

31 March 2020

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Complexity in simplicity: monogenic disorders and complex cardiomyopathies

31 March 2020

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Bioinformatics. Gene counters struggle to get the right answer

31 March 2020

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Chromosomal distribution of the human cardiovascular transcriptome

31 March 2020

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Multiple quantitative trait loci modify the heart failure phenotype in murine cardiomyopathy.

31 March 2020

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Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays

31 March 2020

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Construction of a human cardiovascular cDNA microarray: portrait of the failing heart

31 March 2020

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The gene expression fingerprint of human heart failure

31 March 2020

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Sex- and age-dependent human transcriptome variability: implications for chronic heart failure

31 March 2020

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Gene expression profiling during the transition to failure in TNF-alpha over-expressing mice demonstrates the development of autoimmune myocarditis

31 March 2020

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Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy

31 March 2020

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DNA microarray analysis of in vivo progression mechanism of heart failure

31 March 2020

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Expression profiling of human idiopathic dilated cardiomyopathy

31 March 2020

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Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart

31 March 2020

1 reference

Microarray analysis of changes in gene expression in a murine model of chronic chagasic cardiomyopathy.

31 March 2020

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B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: fibrosis, myofibroblast conversion, proliferation, and inflammation

31 March 2020

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Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy

31 March 2020

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Altered patterns of gene expression in response to myocardial infarction

31 March 2020

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Differential gene expression and genomic patient stratification following left ventricular assist device support

31 March 2020

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Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction

31 March 2020

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Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks.

31 March 2020

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Effects of olmesartan, an angiotensin II receptor blocker, on mechanically-modulated genes in cardiac myocytes

31 March 2020

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Individuality and variation in gene expression patterns in human blood

31 March 2020

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Gene profiling identifies secreted protein transcripts from peripheral blood cells in coronary artery disease.

31 March 2020

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Microarray analysis of gene expression in peripheral blood mononuclear cells derived from long-surviving renal recipients

31 March 2020

1 reference

Interferon and granulopoiesis signatures in systemic lupus erythematosus blood

31 March 2020

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Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats

31 March 2020

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Differential remodeling of the left and right heart after norepinephrine treatment in rats: studies on cytokines and collagen

31 March 2020

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Cardiomyocyte-specific desmin rescue of desmin null cardiomyopathy excludes vascular involvement

31 March 2020

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Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice

31 March 2020

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AlphaB-crystallin modulates protein aggregation of abnormal desmin

31 March 2020

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Skeletal and smooth muscle alpha-actin mRNA in endomyocardial biopsy samples of dilated cardiomyopathy patients

31 March 2020

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Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure

31 March 2020

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Modulation of gene expression in transgenic mouse hearts overexpressing calsequestrin

31 March 2020

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Rapid ventricular pacing of dogs to heart failure: biochemical and physiological studies

31 March 2020

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Enzyme-linked immunosorbent assay for anti-tropomyosin antibodies and its clinical application to various heart diseases

31 March 2020

1 reference

Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome

31 March 2020

1 reference

Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: tissue parasitism and endogenous IFN-gamma as important determinants of chemokine mRNA expression during infection with Trypanosoma cruzi

31 March 2020

2 references

31 March 2020

inferred from DOI database lookup

7 January 2021

based on heuristic

A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection

1 reference

Combined blockade of the chemokine receptors CCR1 and CCR5 attenuates chronic rejection

31 March 2020

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Identification, functional analysis and expression in a heterotopic heart transplant model of CXCL9 in the rat.

31 March 2020

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Cloning and relative expression analysis of rat stromal cell derived factor-1 (SDF-1)1: SDF-1 alpha mRNA is selectively induced in rat model of myocardial infarction

31 March 2020

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Cardiovascular diabetology in the core of a novel interleukins classification: the bad, the good and the aloof

31 March 2020

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Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling

31 March 2020

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Beta-blockers: new standard therapy for heart failure

31 March 2020

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Therapeutic role of angiotensin II receptor blockers in the treatment of heart failure

31 March 2020

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New therapeutics for chronic heart failure

31 March 2020

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Kinases as therapeutic targets for heart failure

31 March 2020

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Hypertrophy of the heart: a new therapeutic target?

31 March 2020

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Cardiomyocyte transplantation into the failing heart-new therapeutic approach for heart failure?

31 March 2020

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Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation

31 March 2020

1 reference

Dilated cardiomyopathy: learning to live with yourself.

31 March 2020

1 reference

Phospholamban: a crucial regulator of cardiac contractility

31 March 2020

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Myocyte hypertrophy and apoptosis: a balancing act.

31 March 2020

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31 March 2020

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The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Expression profiling--best practices for data generation and interpretation in clinical trials

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRG1470

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11 August 2017

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