Epigenetic inactivation of tumor suppressor genes in hematologic malignancies (Q35916788)

Crossref

https://api.crossref.org/works/10.1532%2FIJH97.04056

Overall survival in aggressive B-cell lymphomas is dependent on the accumulation of alterations in p53, p16, and p27.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1532%2FIJH97.04056

Loss of p16/INK4A protein expression in non-Hodgkin's lymphomas is a frequent finding associated with tumor progression

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1532%2FIJH97.04056

Tumor suppressor genes in normal and malignant hematopoiesis

21 January 2018

1 reference

12 December 2020

Cancer-specific region of hypermethylation identified within the HIC1 putative tumour suppressor gene in acute myeloid leukaemia

1 reference

12 December 2020

Prognostic implications of epigenetic silencing of p15INK4B in acute promyelocytic leukemia

1 reference

12 December 2020

Methylation is an inactivating mechanism of the p16 gene in multiple myeloma associated with high plasma cell proliferation and short survival

1 reference

12 December 2020

Mutation and cancer: statistical study of retinoblastoma

1 reference

12 December 2020

Methylation of p15 and p16 genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance

1 reference

12 December 2020

Aberrant methylation of DAP-kinase in therapy-related acute myeloid leukemia and myelodysplastic syndromes

1 reference

12 December 2020

Profiling aberrant DNA methylation in hematologic neoplasms: a view from the tip of the iceberg

1 reference

12 December 2020

HIC1 hypermethylation is a late event in hematopoietic neoplasms

1 reference

12 December 2020

p16(INK4a) and p15(INK4b) gene methylations in plasma cells from monoclonal gammopathy of undetermined significance

1 reference

12 December 2020

E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia.

1 reference

12 December 2020

Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumors

1 reference

12 December 2020

Methylation profiling in acute myeloid leukemia.

1 reference

12 December 2020

Role of hypermethylation of DAP-kinase CpG island in the development of thyroid lymphoma

1 reference

12 December 2020

Lack of p21(CIP1) DNA methylation in acute lymphocytic leukemia

1 reference

12 December 2020

Reduction of p53 gene expression in human primary hepatocellular carcinoma is associated with promoter region methylation without coding region mutation

1 reference

12 December 2020

De novo methylation of tumour suppressor genes CDKN2A and CDKN2B is a rare finding in B‐cell chronic lymphocytic leukaemia

1 reference

12 December 2020

Expression of p15(ink4b) gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors.

1 reference

12 December 2020

De novo methylation of tumor suppressor gene p16/INK4a is a frequent finding in multiple myeloma patients at diagnosis

1 reference

12 December 2020

Methylation of the p15(INK4B) gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation

1 reference

12 December 2020

Deletion of the p16INK4A gene in ex vivo acute adult T cell lymphoma/leukemia cells and methylation of the p16INK4A promoter in HTLV type I-infected T cell lines.

1 reference

12 December 2020

DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas.

1 reference

12 December 2020

Aberrant p15 gene promoter methylation in therapy-related myelodysplastic syndrome and acute myeloid leukaemia: clinicopathological and karyotypic associations

1 reference

12 December 2020

Frequent alterations of the p14(ARF) and p16(INK4a) genes in primary central nervous system lymphomas

1 reference

12 December 2020

Aberrations of the p53 pathway components p53, MDM2 and CDKN2A appear independent in diffuse large B cell lymphoma.

1 reference

12 December 2020

Frequent hypermethylation of p16 and p15 genes in multiple myeloma

1 reference

12 December 2020

Hypermethylation of the p15INK4B gene in myelodysplastic syndromes

1 reference

12 December 2020

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1 reference

12 December 2020

DAP-kinase loss of expression in various carcinoma and B-cell lymphoma cell lines: possible implications for role as tumor suppressor gene

1 reference

12 December 2020

Hypermethylation of the P15INK4b and P16INK4a in agnogenic myeloid metaplasia (AMM) and AMM in leukaemic transformation

1 reference

12 December 2020

Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia

1 reference

12 December 2020

DNA methylation patterns at relapse in adult acute lymphocytic leukemia

1 reference

12 December 2020

ABL1 promoter methylation can exist independently of BCR-ABL transcription in chronic myeloid leukemia hematopoietic progenitors

1 reference

12 December 2020

The estrogen receptor CpG island is methylated in most hematopoietic neoplasms.

1 reference

12 December 2020

p16INK4a loss and sensitivity in KSHV associated primary effusion lymphoma

1 reference

12 December 2020

Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death

1 reference

12 December 2020

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

1 reference

12 December 2020

p14ARF, p15INK4b, and p16INK4a methylation status in chronic myelogenous leukemia

1 reference

12 December 2020

Expression levels of DNA methyltransferase genes do not correlate with p15INK4B gene methylation in myelodysplastic syndromes.

1 reference

12 December 2020

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

12 December 2020

p16(INK4a) is selectively silenced in the tumoral progression of mycosis fungoides

1 reference

12 December 2020

P15INK4B gene methylation and expression in normal, myelodysplastic, and acute myelogenous leukemia cells and in the marrow cells of cured lymphoma patients

1 reference

12 December 2020

Increased DNA methyltransferase expression in leukaemia

1 reference

12 December 2020

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

1 reference

12 December 2020

Methylation of the p16INK4A gene in multiple myeloma

1 reference

12 December 2020

Methylation analysis of cell cycle control genes in adult T-cell leukemia/lymphoma

1 reference

12 December 2020

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1 reference

12 December 2020

Frequent inactivation of thep73gene by abnormal methylation or LOH in non-Hodgkin's lymphomas

1 reference

12 December 2020

Mutational analysis of the CDKN2 (MTS1/p16ink4A) gene in primary B-cell lymphomas

1 reference

12 December 2020

Aberrant gene promoter methylation in acute promyelocytic leukaemia: profile and prognostic significance

1 reference

12 December 2020

Aberrant DNA methylation of p57(KIP2) gene in the promoter region in lymphoid malignancies of B-cell phenotype

1 reference

12 December 2020

Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment

1 reference

12 December 2020

Role of DNA methylation in the suppression of Apaf-1 protein in human leukaemia

1 reference

12 December 2020

Frequent methylation of p16INK4A and p14ARF genes implicated in the evolution of chronic myeloid leukaemia from its chronic to accelerated phase

1 reference

12 December 2020

Biallelic mutations in the ATM gene in T-prolymphocytic leukemia

1 reference

12 December 2020

Bi-allelic silencing of the Fanconi anaemia gene FANCF in acute myeloid leukaemia

1 reference

12 December 2020

Loss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylation

1 reference

12 December 2020

Ataxia-telangiectasia and T-cell leukemias: no evidence for somatic ATM mutation in sporadic T-ALL or for hypermethylation of the ATM-NPAT/E14 bidirectional promoter in T-PLL.

1 reference

12 December 2020

Different incidence and pattern of p15INK4b and p16INK4a promoter region hypermethylation in Hodgkin's and CD30-Positive non-Hodgkin's lymphomas

1 reference

12 December 2020

Characterization of the human p57KIP2 gene: alternative splicing, insertion/deletion polymorphisms in VNTR sequences in the coding region, and mutational analysis

1 reference

12 December 2020

WAF1, a potential mediator of p53 tumor suppression

1 reference

12 December 2020

Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression

1 reference

12 December 2020

Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies

1 reference

12 December 2020

Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis.

1 reference

12 December 2020

Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia

1 reference

12 December 2020

Cadherin-13, a mediator of calcium-dependent cell-cell adhesion, is silenced by methylation in chronic myeloid leukemia and correlates with pretreatment risk profile and cytogenetic response to interferon alfa

1 reference

12 December 2020

Hypermethylation of p15(INK4B) gene in a patient with acute myelogenous leukemia evolved from paroxysmal nocturnal hemoglobinuria

1 reference

12 December 2020

p16/INK4a gene inactivation by hypermethylation is associated with aggressive variants of monoclonal gammopathies

1 reference

12 December 2020

Increasing methylation of the CDKN2A gene is associated with the progression of adult T-cell leukemia.

1 reference

12 December 2020

Altered expression of retinoblastoma (RB) protein in acute myelogenous leukemia does not result from methylation of the Rb promotor

1 reference

12 December 2020

Concurrent disruption of p16INK4a and the ARF-p53 pathway predicts poor prognosis in aggressive non-Hodgkin's lymphoma.

1 reference

12 December 2020

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

1 reference

12 December 2020

Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and sezary syndrome

1 reference

12 December 2020

Relationship between methylation of the p15 gene and ectopic expression of the EVI-1 gene in myelodysplastic syndromes (MDS)

1 reference

12 December 2020

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1 reference

12 December 2020

Aberrant promoter methylation and silencing of the RASSF1A gene in pediatric tumors and cell lines

1 reference

12 December 2020

Transcriptional silencing of the p16 gene in human myeloma-derived cell lines by hypermethylation

1 reference

12 December 2020

Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia

1 reference

12 December 2020

Continuous infusion of low-dose 5-Aza-2'-deoxycytidine in elderly patients with high-risk myelodysplastic syndrome

1 reference

12 December 2020

p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing

1 reference

12 December 2020

Methylation status of the p15INK4B gene in hematopoietic progenitors and peripheral blood cells in myelodysplastic syndromes

1 reference

12 December 2020

Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.

1 reference

12 December 2020

JunB gene expression is inactivated by methylation in chronic myeloid leukemia

1 reference

12 December 2020

Frequent methylation silencing of p15(INK4b) (MTS2) and p16(INK4a) (MTS1) in B-cell and T-cell lymphomas

1 reference

12 December 2020

Specific patterns of gene methylation in natural killer cell lymphomas : p73 is consistently involved

1 reference

12 December 2020

E-cadherin-catenin: more than a "sticky" molecular complex

1 reference

12 December 2020

Cancer epigenetics and methylation

1 reference

12 December 2020

Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies.

1 reference

12 December 2020

5' CpG island hypermethylation is associated with transcriptional silencing of the p21(CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia

1 reference

12 December 2020

Microsatellite instability and hMLH1 promoter hypermethylation in Richter's transformation of chronic lymphocytic leukemia.

1 reference

12 December 2020

Epigenetic targets in hematopoietic malignancies

1 reference

12 December 2020

Frequent inactivation of CDKN2A and rare mutation of TP53 in PCNSL.

1 reference

12 December 2020

Microsatellite mutations of transforming growth factor-beta receptor type II and caspase-5 occur in human precursor T-cell lymphoblastic lymphomas/leukemias in vivo but are not associated with hMSH2 or hMLH1 promoter methylation

1 reference

12 December 2020

Methylation of promoter region in p27 gene plays a role in the development of lymphoid malignancies

1 reference

12 December 2020

Microsatellite instability is associated with hypermethylation of the hMLH1 gene and reduced gene expression in mycosis fungoides

1 reference

12 December 2020

Genomic p16 abnormalities in the progression of chronic myeloid leukemia into blast crisis

1 reference

12 December 2020

Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.

1 reference

12 December 2020

Methylation of the hMLH1 promoter and its association with microsatellite instability in acute myeloid leukemia.

1 reference

12 December 2020

p16(INK4a) gene alterations are frequent in lesions of mycosis fungoides

1 reference

12 December 2020

Mantle cell lymphoma is characterized by inactivation of the ATM gene

1 reference

12 December 2020

Absence of WAF1 mutations in a variety of human malignancies

1 reference

12 December 2020

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1 reference

12 December 2020

Low-dose 5-aza-2'-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients

1 reference

12 December 2020

Hypermethylation of a 5′ CpG island of p16 is a frequent event in non-Hodgkin’s lymphoma

1 reference

12 December 2020

KG-1 and KG-1a model the p15 CpG island methylation observed in acute myeloid leukemia patients.

1 reference

12 December 2020

Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications

1 reference

12 December 2020

Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias

1 reference

12 December 2020

H-cadherin, a novel cadherin with growth inhibitory functions and diminished expression in human breast cancer

1 reference

12 December 2020

E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas

1 reference

12 December 2020

CpG island methylation of tumor-related genes in three primary central nervous system lymphomas in immunocompetent patients

1 reference

12 December 2020

Aberrant methylation and impaired expression of the p15(INK4b) cell cycle regulatory gene in chronic myelomonocytic leukemia (CMML).

1 reference

12 December 2020

The absence of the p15INK4B gene alterations in adult patients with precursor B-cell acute lymphoblastic leukaemia is a favourable prognostic factor

1 reference

12 December 2020

Hypermethylation of E-cadherin in leukemia

1 reference

12 December 2020

Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic leukemia

1 reference

12 December 2020

TP53is frequently altered by methylation, mutation, and/or deletion in acute lymphoblastic leukaemia

1 reference

12 December 2020

Epigenetic changes in the DAP‐kinase CpG island in pediatric lymphoma

1 reference

12 December 2020

Anticorresponding p15 promoter methylation and microsatellite instability in acute myeloblastic leukemia

1 reference

12 December 2020

Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia

1 reference

12 December 2020

Hypermethylation of death‐associated protein (DAP) kinase CpG island is frequent not only in B‐cell but also in T‐ and natural killer (NK)/T‐cell malignancies

1 reference

12 December 2020

Different patterns of homozygous p16INK4A and p15INK4B deletions in childhood acute lymphoblastic leukemias containing distinct E2A translocations

1 reference

12 December 2020

Quantitative measure of c-abl and p15 methylation in chronic myelogenous leukemia: biological implications

1 reference

12 December 2020

Characterization of p16(INK4A) expression in multiple myeloma and plasma cell leukemia

1 reference

12 December 2020

Induction of Tumors in Mice by Genomic Hypomethylation

1 reference

12 December 2020

The androgen receptor gene is preferentially hypermethylated in follicular non-Hodgkin's lymphomas

1 reference

12 December 2020

Methylation of the ABL1 promoter in chronic myelogenous leukemia: lack of prognostic significance

1 reference

12 December 2020

Cadherin cell adhesion receptors as a morphogenetic regulator

1 reference

12 December 2020

Selective variegated methylation of the p15 CpG island in acute myeloid leukemia

1 reference

12 December 2020

Alterations of the cyclin D1/pRb/p16(INK4A) pathway in multiple myeloma

1 reference

12 December 2020

Hypermethylation of p16INK4A gene promoter during the progression of plasma cell dyscrasia

1 reference

12 December 2020

Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia

1 reference

12 December 2020

Methylation of p15 and p16 genes in adult acute leukemia: lack of prognostic significance

1 reference

12 December 2020

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

1 reference

12 December 2020

Molecular features of primary mediastinal B-cell lymphoma: involvement of p16INK4A, p53 and c-myc

1 reference

12 December 2020

Inactivation of tumor suppressor genes p15(INK4b) and p16(INK4a) in primary cutaneous B cell lymphoma.

1 reference

12 December 2020

Single-site methylation within the p53 promoter region reduces gene expression in a reporter gene construct: possible in vivo relevance during tumorigenesis.

1 reference

12 December 2020

Aberrant promoter CpG methylation as a molecular marker for disease monitoring in natural killer cell lymphomas

1 reference

12 December 2020

Frequent death-associated protein kinase promoter hypermethylation in multiple myeloma

1 reference

12 December 2020

Hypermethylation of p15/ink4b/MTS2 gene is differentially implicated among non-Hodgkin's lymphomas

1 reference

12 December 2020

Aberrant methylation in promoter-associated CpG islands of multiple genes in therapy-related leukemia.

1 reference

12 December 2020

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1 reference

12 December 2020

p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in childhood acute lymphoblastic leukemia with 11q23 translocation.

1 reference

12 December 2020

Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene

1 reference

12 December 2020

CpG methylation inactivates the transcriptional activity of the promoter of the human p53 tumor suppressor gene

1 reference

12 December 2020

The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas

1 reference

12 December 2020

Frequent aberrant promoter hypermethylation of O6-methylguanine-DNA methyltransferase and death-associated protein kinase genes in immunodeficiency-related lymphomas.

1 reference

12 December 2020

DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia

1 reference

12 December 2020

Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors

1 reference

12 December 2020

Extensive intra- and interindividual heterogeneity of p15INK4B methylation in acute myeloid leukemia

1 reference

12 December 2020

Acquisition of p16(INK4A) and p15(INK4B) gene abnormalities between initial diagnosis and relapse in children with acute lymphoblastic leukemia

1 reference

12 December 2020

p57(KIP2) is not mutated in hepatoblastoma but shows increased transcriptional activity in a comparative analysis of the three imprinted genes p57(KIP2), IGF2, and H19

1 reference

12 December 2020

Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia.

1 reference

12 December 2020

Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia

1 reference

12 December 2020

Mutations of the p53 Gene as a Prognostic Factor in Aggressive B-Cell Lymphoma

1 reference

12 December 2020

Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia

1 reference

12 December 2020

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

12 December 2020

Frequent deletion and 5' CpG island methylation of the p16 gene in primary malignant lymphoma of the brain.

1 reference

12 December 2020

Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias

1 reference

12 December 2020

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene

1 reference

12 December 2020

Estrogen receptor methylation is associated with improved survival in adult acute myeloid leukemia

1 reference

12 December 2020

Epigenetic inactivation of INK4/CDK/RB cell cycle pathway in acute leukemias.

1 reference

12 December 2020

A cell cycle regulator potentially involved in genesis of many tumor types

1 reference

12 December 2020

Concurrent methylation of multiple genes in childhood ALL: Correlation with phenotype and molecular subgroup.

1 reference

12 December 2020

Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation

1 reference

12 December 2020

Methylation of CpG dinucleotides and/or CCWGG motifs at the promoter of TP53 correlates with decreased gene expression in a subset of acute lymphoblastic leukemia patients

1 reference

12 December 2020

Clustering of missense mutations in the ataxia-telanglectasia gene in a sporadic T-cell leukaemia

1 reference

12 December 2020

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

1 reference

12 December 2020

Status of methylation of p16 gene in multiple myeloma: a comparative study of three methods for its detection

1 reference

12 December 2020