Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr (Q35890940)

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scientific article published on September 1, 1997

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English	Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr	scientific article published on September 1, 1997

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261351%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr (English)

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5 November 2019

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S. Mahalingam

1

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11 November 2024

V. Ayyavoo

2

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11 November 2024

M. Patel

3

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11 November 2024

T. Kieber-Emmons

4

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11 November 2024

D. B. Weiner

5

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11 November 2024

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1 September 1997

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5 November 2019

September 1997

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National Center for Biotechnology Information

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11 November 2024

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https://jvi.asm.org/content/jvi/71/9/6339.full.pdf

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11 November 2024

http://jvi.asm.org/cgi/content/abstract/71/9/6339

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11 November 2024

https://europepmc.org/articles/PMC191907

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Europe PubMed Central

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11 November 2024

https://europepmc.org/articles/PMC191907?pdf=render

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Europe PubMed Central

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11 November 2024

https://journals.asm.org/doi/pdf/10.1128/jvi.71.9.6339-6347.1997

1 reference

10.1128/JVI.71.9.6339-6347.1997

https://api.crossref.org/works/10.1128/JVI.71.9.6339-6347.1997

11 November 2024

Journal of Virology

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Europe PubMed Central

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5 November 2019

71

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5 November 2019

9

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5 November 2019

6339-6347

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261351%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

In vitro and in vivo tumor growth suppression by HIV-1 Vpr.

1 reference

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27 July 2018

Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIV(SM).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191907

27 July 2018

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

1 reference

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Antisense phosphorothioate oligodeoxynucleotides targeted to the vpr gene inhibit human immunodeficiency virus type 1 replication in primary human macrophages

1 reference

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Vpx of simian immunodeficiency virus is localized primarily outside the virus core in mature virions.

1 reference

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27 July 2018

Induction of cell differentiation by human immunodeficiency virus 1 vpr.

1 reference

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Context-dependent role of human immunodeficiency virus type 1 auxiliary genes in the establishment of chronic virus producers.

1 reference

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Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions

1 reference

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27 July 2018

Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus.

1 reference

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Mutational analysis of the nucleic acid-binding 17 kDa phosphoprotein of potato leafroll luteovirus identifies an amphipathic alpha-helix as the domain for protein/protein interactions

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27 July 2018

Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate

1 reference

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27 July 2018

Requirement of the Pr55gag precursor for incorporation of the Vpr product into human immunodeficiency virus type 1 viral particles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191907

27 July 2018

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells

1 reference

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Dimerization of thiol-specific antioxidant and the essential role of cysteine 47.

1 reference

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27 July 2018

Serum Vpr regulates productive infection and latency of human immunodeficiency virus type 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191907

27 July 2018

Molecular biology of the human immunodeficiency virus accessory proteins

1 reference

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27 July 2018

Particle assembly and Vpr expression in human immunodeficiency virus type 1-infected cells demonstrated by immunoelectron microscopy

1 reference

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27 July 2018

Progression to AIDS in the absence of a gene for vpr or vpx.

1 reference

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27 July 2018

The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191907

27 July 2018

Biochemical mechanism of HIV-1 Vpr function. Oligomerization mediated by the N-terminal domain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191907

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The glucocorticoid receptor type II complex is a target of the HIV-1 vpr gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191907

27 July 2018

The p6gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particles

1 reference

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A virion-specific inhibitory molecule with therapeutic potential for human immunodeficiency virus type 1

1 reference

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The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle

1 reference

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Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191907

27 July 2018

Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191907

27 July 2018

Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191907

27 July 2018

Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B

1 reference

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Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity

1 reference

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Statistical and functional analyses of viral and cellular proteins with N-terminal amphipathic alpha-helices with large hydrophobic moments: importance to macromolecular recognition and organelle targeting

1 reference

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Disulphide bonds and protein stability

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Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes

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Site-directed mutagenesis by overlap extension using the polymerase chain reaction

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Viral protein R of human immunodeficiency virus types 1 and 2 is dispensable for replication and cytopathogenicity in lymphoid cells.

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Mutational analysis of the human immunodeficiency virus vpr open reading frame.

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Improvements in protein secondary structure prediction by an enhanced neural network

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Human immunodeficiency virus vpr gene encodes a virion-associated protein

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Open reading frame vpr of simian immunodeficiency virus encodes a virion-associated protein

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Human immunodeficiency virus vpr product is a virion-associated regulatory protein

1 reference

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Identification of HIV-1 vpr product and function

1 reference

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Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs

1 reference

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Rev activates expression of the human immunodeficiency virus type 1 vif and vpr gene products

1 reference

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Regulation of human immunodeficiency virus replication

1 reference

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Generation and characterization of the human immunodeficiency virus type 1 mutants

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Nuclear targeting sequences--a consensus?

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Biological characterization of human immunodeficiency virus type 1 and type 2 mutants in human peripheral blood mononuclear cells

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Evolution of the primate lentiviruses: evidence from vpx and vpr

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Empirical Predictions of Protein Conformation

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Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein.

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Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein

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Extracellular Vpr protein increases cellular permissiveness to human immunodeficiency virus replication and reactivates virus from latency.

1 reference

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Mutagenesis of the putative alpha-helical domain of the Vpr protein of human immunodeficiency virus type 1: effect on stability and virion incorporation

1 reference

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24 September 2018

A domain of human immunodeficiency virus type 1 Vpr containing repeated H(S/F)RIG amino acid motifs causes cell growth arrest and structural defects.

1 reference

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The vpr Regulatory Gene of HIV

1 reference

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24 September 2018

Is the hydrophobic effect stabilizing or destabilizing in proteins?

1 reference

https://pubmed.ncbi.nlm.nih.gov/9261351

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of residues in the N-terminal acidic domain of HIV-1 Vpr essential for virion incorporation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9261351

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the conserved dipeptide Gly75 and Cys76 on HIV-1 Vpr function

1 reference

https://pubmed.ncbi.nlm.nih.gov/9261351

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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