Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria (Q35860341)

10 August 2017

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria (English)

1 reference

amyotrophic lateral sclerosis

10 August 2017

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author name string

Gábor M Mórotz

1 reference

10 August 2017

Kurt J De Vos

1 reference

10 August 2017

Alessio Vagnoni

1 reference

10 August 2017

Steven Ackerley

1 reference

10 August 2017

Christopher E Shaw

1 reference

10 August 2017

Christopher C J Miller

1 reference

10 August 2017

17 January 2012

1 reference

10 August 2017

Human Molecular Genetics

1 reference

10 August 2017

1 reference

10 August 2017

1 reference

10 August 2017

1979-1988

1 reference

describes a project that uses

10 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3315205/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Trafficking kinesin protein (TRAK)-mediated transport of mitochondria in axons of hippocampal neurons

27 July 2018

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Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1.

27 July 2018

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Characterization of the Properties of a Novel Mutation in VAPB in Familial Amyotrophic Lateral Sclerosis

27 July 2018

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Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B(P56S) neurotoxicity.

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Calcium dysregulation in amyotrophic lateral sclerosis

27 July 2018

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27 July 2018

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Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients

27 July 2018

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ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.

27 July 2018

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The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility

27 July 2018

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GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons

27 July 2018

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Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase

27 July 2018

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Coordinated lipid transfer between the endoplasmic reticulum and the Golgi complex requires the VAP proteins and is essential for Golgi-mediated transport

27 July 2018

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Role of axonal transport in neurodegenerative diseases

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The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors

27 July 2018

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A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism

27 July 2018

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VAPB interacts with and modulates the activity of ATF6.

27 July 2018

1 reference

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Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes.

27 July 2018

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Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent

27 July 2018

1 reference

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The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking

27 July 2018

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Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons

27 July 2018

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The axonal transport of mitochondria.

27 July 2018

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Mutations in the neurofilament light gene linked to Charcot-Marie-Tooth disease cause defects in transport

27 July 2018

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GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin

27 July 2018

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Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit

27 July 2018

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A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis

27 July 2018

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Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments.

27 July 2018

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Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner

27 July 2018

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Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria

27 July 2018

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Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila

27 July 2018

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Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons

27 July 2018

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Cloning and localization of a conventional kinesin motor expressed exclusively in neurons

27 July 2018

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A new generation of Ca2+ indicators with greatly improved fluorescence properties

27 July 2018

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VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

27 July 2018

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Deficits in axonal transport precede ALS symptoms in vivo

24 September 2018

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AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway

24 September 2018

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Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

24 September 2018

1 reference

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Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

FFAT rescues VAPA-mediated inhibition of ER-to-Golgi transport and VAPB-mediated ER aggregation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

New VAPB deletion variant and exclusion of VAPB mutations in familial ALS.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

Visualization and quantification of mitochondrial dynamics in living animal cells.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

Unloading kinesin transported cargoes from the tubulin track via the inflammatory c-Jun N-terminal kinase pathway.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

Mitochondrial trafficking to synapses in cultured primary cortical neurons.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

Syntabulin-mediated anterograde transport of mitochondria along neuronal processes

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

Glutamate decreases mitochondrial size and movement in primary forebrain neurons.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

Glutamate slows axonal transport of neurofilaments in transfected neurons

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

Calcium dysregulation, mitochondrial pathology and protein aggregation in a culture model of amyotrophic lateral sclerosis: mechanistic relationship and differential sensitivity to intervention

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3315205

A VAPB mutant linked to amyotrophic lateral sclerosis generates a novel form of organized smooth endoplasmic reticulum

22 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22258555

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Neuronal Adaptor Protein X11β Reduces Amyloid β-Protein Levels and Amyloid Plaque Formation in the Brains of Transgenic Mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22258555

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDS011

1 reference

10 August 2017

1 reference

10 August 2017

PubMed publication ID

22258555

1 reference