Regulation of the DNA replication fork: a way to fight genomic instability (Q35858504)

10 August 2017

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title

Regulation of the DNA replication fork: a way to fight genomic instability (English)

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10 August 2017

Magali Toueille

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10 August 2017

Ulrich Hübscher

series ordinal

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10 August 2017

publication date

6 August 2004

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10 August 2017

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10 August 2017

volume

113

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10 August 2017

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10 August 2017

page(s)

113-125

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Functional interaction between the Werner Syndrome protein and DNA polymerase delta

10 August 2017

cites work

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12 December 2020

Mechanisms of human DNA repair: an update

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12 December 2020

Checkpoint-mediated control of replisome–fork association and signalling in response to replication pausing

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12 December 2020

A unified view of the DNA-damage checkpoint

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12 December 2020

Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae

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12 December 2020

Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes

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12 December 2020

Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen.

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12 December 2020

The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21

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12 December 2020

Replication protein A-mediated recruitment and activation of Rad17 complexes

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12 December 2020

Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability

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12 December 2020

Structure-function analysis of fission yeast Hus1-Rad1-Rad9 checkpoint complex

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12 December 2020

Colocalization of human Rad17 and PCNA in late S phase of the cell cycle upon replication block

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12 December 2020

Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA

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12 December 2020

Isolation and characterization of new proliferating cell nuclear antigen (POL30) mutator mutants that are defective in DNA mismatch repair

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12 December 2020

The DNA replication fork in eukaryotic cells.

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12 December 2020

The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.

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12 December 2020

Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event

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12 December 2020

Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300

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12 December 2020

A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function

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12 December 2020

Nuclear factories for signalling and repairing DNA double strand breaks in living fission yeast.

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12 December 2020

hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci

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12 December 2020

Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18.

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12 December 2020

Purification and characterization of human DNA damage checkpoint Rad complexes

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12 December 2020

Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

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12 December 2020

Targeting of human DNA polymerase iota to the replication machinery via interaction with PCNA.

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12 December 2020

CDC 45 is required in conjunction with CDC 7/ DBF 4 to trigger the initiation of DNA replication

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12 December 2020

The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase

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12 December 2020

Quality control by DNA repair

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12 December 2020

Smart machines at the DNA replication fork.

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12 December 2020

Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication

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12 December 2020

Resistance of human nucleotide excision repair synthesis in vitro to p21Cdn1.

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12 December 2020

Proliferating cell nuclear antigen (PCNA): a dancer with many partners

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12 December 2020

High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading

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12 December 2020

Two checkpoint complexes are independently recruited to sites of DNA damage in vivo

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12 December 2020

hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation

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12 December 2020

Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA

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12 December 2020

Molecular architecture of the mouse DNA polymerase alpha-primase complex

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12 December 2020

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

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12 December 2020

DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae

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12 December 2020

Properties and functions of human uracil-DNA glycosylase from the UNG gene

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12 December 2020

Interaction with PCNA is essential for yeast DNA polymerase eta function

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12 December 2020

Defective DNA polymerase-delta proofreading causes cancer susceptibility in mice

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12 December 2020

mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p

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12 December 2020

Molecular anatomy of the human excision nuclease assembled at sites of DNA damage

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12 December 2020

Mechanism of 5'-directed excision in human mismatch repair

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12 December 2020

Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene

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12 December 2020

Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint

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12 December 2020

The DNA damage response: putting checkpoints in perspective

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12 December 2020

Cut5 Is Required for the Binding of Atr and DNA Polymerase α to Genotoxin-damaged Chromatin

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12 December 2020

DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading

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12 December 2020

DNA polymerase switching: II. Replication factor C abrogates primer synthesis by DNA polymerase alpha at a critical length

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12 December 2020

Long patch base excision repair with purified human proteins. DNA ligase I as patch size mediator for DNA polymerases delta and epsilon

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12 December 2020

Chk1 activation requires Rad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1

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12 December 2020

The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides

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12 December 2020

Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC.

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12 December 2020

Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis

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12 December 2020

Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex

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12 December 2020

The reconstituted human Chl12-RFC complex functions as a second PCNA loader

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12 December 2020

Structure of the replicating complex of a pol alpha family DNA polymerase

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12 December 2020

Role of Saccharomyces single-stranded DNA-binding protein RPA in the strand invasion step of double-strand break repair

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12 December 2020

Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication

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12 December 2020

Checkpoint activation regulates mutagenic translesion synthesis

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12 December 2020

Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases, alpha and delta

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12 December 2020

The Rad51-dependent pairing of long DNA substrates is stabilized by replication protein A.

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12 December 2020

Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA.

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12 December 2020

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

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12 December 2020

Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast

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12 December 2020

Physical and functional interactions of human DNA polymerase eta with PCNA

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12 December 2020

Stimulation of 3'-->5' exonuclease and 3'-phosphodiesterase activities of yeast apn2 by proliferating cell nuclear antigen

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12 December 2020

Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs

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12 December 2020

Eukaryotic DNA Polymerases

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12 December 2020

Lagging strand DNA synthesis by calf thymus DNA polymerases alpha, beta, delta and epsilon in the presence of auxiliary proteins

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12 December 2020

Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy

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12 December 2020

FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair.

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12 December 2020

ELG1, a yeast gene required for genome stability, forms a complex related to replication factor C

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12 December 2020

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

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12 December 2020

Replication of the lagging strand: a concert of at least 23 polypeptides

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12 December 2020

Multiple competition reactions for RPA order the assembly of the DNA polymerase delta holoenzyme.

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12 December 2020

Okazaki fragment processing: modulation of the strand displacement activity of DNA polymerase delta by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap endonuclease-1.

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12 December 2020

Replication protein A as a "fidelity clamp" for DNA polymerase alpha

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12 December 2020

ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome

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12 December 2020

Mammalian base excision repair by DNA polymerases delta and epsilon

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12 December 2020

RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes

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12 December 2020

DNA replication machinery: functional characterization of a complex containing DNA polymerase alpha, DNA polymerase delta, and replication factor C suggests an asymmetric DNA polymerase dimer

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12 December 2020

Activation of the DNA replication checkpoint through RNA synthesis by primase

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12 December 2020

Pathway correcting DNA replication errors in Saccharomyces cerevisiae

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12 December 2020

Eukaryotic MCM proteins: beyond replication initiation

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12 December 2020

GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast

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12 December 2020

Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro

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12 December 2020

The nature of the 5'-terminus is a major determinant for DNA processing by Schizosaccharomyces pombe Rad2p, a FEN-1 family nuclease

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12 December 2020

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses.

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12 December 2020

The 3' 5' exonucleases

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12 December 2020

Detection of nucleotide excision repair incisions in human fibroblasts by immunostaining for PCNA.

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12 December 2020

A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair

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12 December 2020

A coordinated interplay: proteins with multiple functions in DNA replication, DNA repair, cell cycle/checkpoint control, and transcription

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12 December 2020

Order of assembly of human DNA repair excision nuclease

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12 December 2020

Regulation of eukaryotic DNA replication at the initiation step

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12 December 2020

Schizosaccharomyces pombe cells lacking the amino-terminal catalytic domains of DNA polymerase epsilon are viable but require the DNA damage checkpoint control

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12 December 2020

Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex

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12 December 2020

Okazaki fragment maturation in yeast. I. Distribution of functions between FEN1 AND DNA2.

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12 December 2020

Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair

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12 December 2020

Multiple roles for kinases in DNA replication

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12 December 2020

Visualization of replication factories attached to nucleoskeleton

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12 December 2020

A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication

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12 December 2020

The comings and goings of nucleotide excision repair factors on damaged DNA

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12 December 2020

Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes

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12 December 2020

In eukaryotic flap endonuclease 1, the C terminus is essential for substrate binding

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12 December 2020

Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats

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12 December 2020

Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21.

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12 December 2020

Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint

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12 December 2020

Retention of the human Rad9 checkpoint complex in extraction-resistant nuclear complexes after DNA damage

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12 December 2020

Characterization of the alternative excision repair pathway of UV-damaged DNA in Schizosaccharomyces pombe.

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12 December 2020

Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase Cdk.

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12 December 2020

Essential role of Sna41/Cdc45 in loading of DNA polymerase alpha onto minichromosome maintenance proteins in fission yeast.

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12 December 2020

DNA ligase I competes with FEN1 to expand repetitive DNA sequences in vitro

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12 December 2020

The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy

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12 December 2020

Destabilization of yeast micro- and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase delta (pol3-t).

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12 December 2020

Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms

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12 December 2020

Interactions between two catalytically distinct MCM subgroups are essential for coordinated ATP hydrolysis and DNA replication

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12 December 2020

Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA

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12 December 2020

Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.

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12 December 2020

Okazaki fragment maturation in yeast. II. Cooperation between the polymerase and 3'-5'-exonuclease activities of Pol delta in the creation of a ligatable nick

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12 December 2020

Xenopus Cut5 is essential for a CDK-dependent process in the initiation of DNA replication

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12 December 2020

Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro

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12 December 2020

Partial reconstitution of human interstrand cross-link repair in vitro: characterization of the roles of RPA and PCNA.

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12 December 2020

Effect of XPA gene mutations on UV-induced immunostaining of PCNA in fibroblasts from xeroderma pigmentosum group A patients

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12 December 2020

ELG1, a regulator of genome stability, has a role in telomere length regulation and in silencing

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12 December 2020

Genome maintenance mechanisms for preventing cancer

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12 December 2020

Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro

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12 December 2020

Biochemical characterization of the WRN-FEN-1 functional interaction

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12 December 2020

XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis

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12 December 2020

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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12 December 2020

Enigmatic variations: divergent modes of regulating eukaryotic DNA replication

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12 December 2020

Elg1 forms an alternative RFC complex important for DNA replication and genome integrity

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12 December 2020

10.1007/S00412-004-0303-7

Identifiers

DOI

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10 August 2017

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