Is angiopoietin-2 necessary for the initiation of tumor angiogenesis? (Q35754557)

10 August 2017

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title

Is angiopoietin-2 necessary for the initiation of tumor angiogenesis? (English)

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10 August 2017

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K Alitalo

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J Laurén

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10 August 2017

Y Gunji

series ordinal

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10 August 2017

language of work or name

English

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publication date

1 November 1998

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The American Journal of Pathology

10 August 2017

published in

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10 August 2017

volume

153

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10 August 2017

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10 August 2017

page(s)

1333-1339

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The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R

10 August 2017

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Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization

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2 October 2017

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Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2

2 October 2017

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Angiopoietin-1 induces sprouting angiogenesis in vitro

2 October 2017

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Expression of Tie2/Tek in breast tumour vasculature provides a new marker for evaluation of tumour angiogenesis

2 October 2017

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Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth

2 October 2017

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Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

2 October 2017

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Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

2 October 2017

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A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis

2 October 2017

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2 October 2017

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2 October 2017

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Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

2 October 2017

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Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

2 October 2017

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Blood vessel formation: what is its molecular basis?

2 October 2017

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2 October 2017

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The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

2 October 2017

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2 October 2017

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Endothelial Tie growth factor receptor provides antigenic marker for assessment of breast cancer angiogenesis

2 October 2017

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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

2 October 2017

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

2 October 2017

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Adhesion in cell migration

2 October 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1853422

Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells.

2 October 2017

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Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system

2 October 2017

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Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells

2 October 2017

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Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta

2 October 2017

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2 October 2017

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2 October 2017

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2 October 2017

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Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo

2 October 2017

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Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors.

2 October 2017

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2 October 2017

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Angiogenesis in cancer, vascular, rheumatoid and other disease

2 October 2017

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Between molecules and morphology. Extracellular matrix and creation of vascular form.

2 October 2017

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Endothelial receptor tyrosine kinases involved in angiogenesis.

2 October 2017

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Multiple essential functions of neuregulin in development

2 October 2017

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Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein

2 October 2017

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Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells

2 October 2017

1 reference

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An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes

2 October 2017

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Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture

2 October 2017

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Expression of the high molecular weight melanoma-associated antigen by pericytes during angiogenesis in tumors and in healing wounds.

2 October 2017

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What Is the Evidence That Tumors Are Angiogenesis Dependent?

2 October 2017

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A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains

2 October 2017

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Epidermal growth factor receptor at endothelial cell and pericyte interdigitation in human granulation tissue

2 October 2017

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Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis

2 October 2017

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Antiangiogenic tumour therapy: will it work?

12 July 2018

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Signaling angiogenesis and lymphangiogenesis

12 July 2018

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A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF.

12 July 2018

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12 July 2018

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Signaling Vascular Morphogenesis and Maintenance

12 July 2018

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12 July 2018

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12 July 2018

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Cell autonomous functions of the receptor tyrosine kinase TIE in a late phase of angiogenic capillary growth and endothelial cell survival during murine development

12 July 2018

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12 July 2018

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12 July 2018

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tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors

12 July 2018

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Capillary endothelial cells secrete a heparin-binding mitogen for pericytes

12 July 2018

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12 July 2018

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Regulation of angiopoietin-2 mRNA levels in bovine microvascular endothelial cells by cytokines and hypoxia.

12 July 2018

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Isolation of the zebrafish homologues for the tie-1 and tie-2 endothelium-specific receptor tyrosine kinases

25 September 2018

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Aortic Smooth Muscle Cells Interact with Tenascin-C through Its Fibrinogen-like Domain

25 September 2018

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Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues

25 September 2018

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Tie2 receptor expression and phosphorylation in cultured cells and mouse tissues

25 September 2018

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The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors.

25 September 2018

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Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family

25 September 2018

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Vascularization of the mouse embryo: A study of flk‐1, tek, tie, and vascular endothelial growth factor expression during development

25 September 2018

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Pieces of eight: bioactive fragments of extracellular proteins as regulators of angiogenesis

25 September 2018

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Tenascin-C hexabrachion assembly is a sequential two-step process initiated by coiled-coil alpha-helices

7 January 2021

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Analysis of Tie receptor tyrosine kinase in haemopoietic progenitor and leukaemia cells

7 January 2021

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Increased vascularization in mice overexpressing angiopoietin-1

7 January 2021

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Pericyte involvement in capillary sprouting during angiogenesis in situ

7 January 2021

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Rat aortic smooth muscle cells become pericytes during angiogenesis in vitro

7 January 2021

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PubMed

https://pubmed.ncbi.nlm.nih.gov/9811321

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Enhanced expression of the tie receptor tyrosine kinase mesenger RNA in the vascular endothelium of metastatic melanomas

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9811321

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/S0002-9440(10)65717-3

1 reference

10 August 2017

1 reference

10 August 2017

1 reference