Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression (Q35742357)

25650659

10 August 2017

title

Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression (English)

1 reference

10 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25650659%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25650659%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25650659%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25650659%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25650659%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Sabrina Strano

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25650659%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Giovanni Blandino

series ordinal

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1 June 2020

language of work or name

English

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publication date

1 March 2015

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10 August 2017

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1 June 2020

volume

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issue

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1 June 2020

page(s)

5547-5566

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25650659%20AND%20SRC:MED&resulttype=core&format=json

The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele

1 June 2020

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Expression of TP53 mutation-associated microRNAs predicts clinical outcome in head and neck squamous cell carcinoma patients.

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TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.

27 July 2018

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A Pin1/mutant p53 axis promotes aggressiveness in breast cancer

27 July 2018

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27 July 2018

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ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters.

27 July 2018

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Modulation of the vitamin D3 response by cancer-associated mutant p53

27 July 2018

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The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis.

27 July 2018

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Meta-analysis of gene expression profiles related to relapse-free survival in 1,079 breast cancer patients.

27 July 2018

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The disruption of the protein complex mutantp53/p73 increases selectively the response of tumor cells to anticancer drugs

27 July 2018

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An oncogene-induced DNA damage model for cancer development

27 July 2018

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An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations

27 July 2018

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Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence

27 July 2018

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TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer

27 July 2018

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DNA damage checkpoints: from initiation to recovery or adaptation

27 July 2018

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Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

27 July 2018

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Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species.

27 July 2018

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Hypoxia-induced down-regulation of BRCA1 expression by E2Fs.

27 July 2018

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Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

27 July 2018

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability

27 July 2018

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27 July 2018

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27 July 2018

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Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

27 July 2018

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27 July 2018

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Cancer susceptibility and the functions of BRCA1 and BRCA2

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467386

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467386

Mutant p53 cooperates with ETS and selectively up-regulates human MDR1 not MRP1.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467386

A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467386

Genomic structure and mutation screening of the E2F4 gene in human tumors

27 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467386

27 July 2018

The Hallmarks of Cancer

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p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467386

DNA end-joining catalyzed by human cell-free extracts

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467386

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467386

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

25 September 2018

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miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467386

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

25 September 2018

1 reference

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Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467386

Genetic alterations of hepatocellular carcinoma by random amplified polymorphic DNA analysis and cloning sequencing of tumor differential DNA fragment

25 September 2018

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

25 September 2018

1 reference

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ONCOMINE: a cancer microarray database and integrated data-mining platform

25 September 2018

1 reference

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The interaction of p53 with the nuclear matrix is mediated by F-actin and modulated by DNA damage.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467386

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467386

Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4467386

Downregulation of RAD17 in head and neck cancer

15 November 2018

1 reference

12 December 2020

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

1 reference

12 December 2020

Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells

1 reference

12 December 2020

Allelic expression imbalance of TP53 mutated and polymorphic alleles in head and neck tumors

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12 December 2020

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

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12 December 2020

Identifiers

DOI

10.18632/ONCOTARGET.2587

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25650659%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25650659%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

25650659

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25650659%20AND%20SRC:MED&resulttype=core&format=json