Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multidrug resistance (Q35699612)

9 August 2017

title

Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multidrug resistance (English)

1 reference

9 August 2017

main subject

multiple drug resistance

1 reference

1 reference

Daniel I S Rosenbloom

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038564%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038564%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038564%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Martin A Nowak

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038564%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Stefany Moreno-Gamez

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038564%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Alison L Hill

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038564%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

language of work or name

English

0 references

publication date

18 May 2015

1 reference

Proceedings of the National Academy of Sciences of the United States of America

9 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038564%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

112

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12 June 2020

issue

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12 June 2020

page(s)

E2874-83

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038564%20AND%20SRC:MED&resulttype=core&format=json

Spatial heterogeneity in drug concentrations can facilitate the emergence of resistance to cancer therapy

12 June 2020

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the male and female genital tract

12 July 2018

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Multidrug-resistant tuberculosis not due to noncompliance but to between-patient pharmacokinetic variability

12 July 2018

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12 July 2018

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Hepatitis B virus resistance to antiviral drugs: where are we going?

12 July 2018

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12 July 2018

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Therapy failure following selection of enfuvirtide-resistant HIV-1 in cerebrospinal fluid

12 July 2018

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Vancomycin in combination with other antibiotics for the treatment of serious methicillin-resistant Staphylococcus aureus infections

12 July 2018

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The rate at which asexual populations cross fitness valleys

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Stochastic tunnels in evolutionary dynamics

12 July 2018

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12 July 2018

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12 July 2018

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The evolution of drug-resistant malaria: the role of drug elimination half-life

12 July 2018

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Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy

12 July 2018

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The penetration of anti-infectives into the central nervous system

12 July 2018

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Drug concentration heterogeneity facilitates the evolution of drug resistance.

12 July 2018

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12 July 2018

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Lamivudine‐Resistant Human Immunodeficiency Virus Type 1 Variants (184V) Require Multiple Amino Acid Changes to Become Co‐Resistant to Zidovudine In Vivo

12 July 2018

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12 July 2018

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12 July 2018

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Evolutionary rescue in structured populations

12 July 2018

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25 September 2018

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Long-term probability of detecting drug-resistant HIV in treatment-naive patients initiating combination antiretroviral therapy

25 September 2018

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Effect of vancomycin plus rifampicin in the treatment of nosocomial methicillin-resistant Staphylococcus aureus pneumonia

25 September 2018

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Antibiotic interactions that select against resistance

25 September 2018

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Evolution of multi-drug resistant hepatitis B virus during sequential therapy

25 September 2018

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Efficacy of cerebrospinal fluid (CSF)-penetrating antiretroviral drugs against HIV in the neurological compartment: different patterns of phenotypic resistance in CSF and plasma

25 September 2018

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Recombination in HIV and the evolution of drug resistance: for better or for worse?

25 September 2018

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Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock

25 September 2018

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The frequency of resistant mutant virus before antiviral therapy

25 September 2018

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25 September 2018

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25 September 2018

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25 September 2018

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The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy

21 January 2018

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Mutational Pathway Determines Whether Drug Gradients Accelerate Evolution of Drug-Resistant Cells

21 January 2018

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1424184112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038564%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038564%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26038564%20AND%20SRC:MED&resulttype=core&format=json