Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine. (Q35683922)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22291509%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

title

Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine (English)

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21 January 2020

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Maria Virginia Soldovieri

21 January 2020

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21 January 2020

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21 January 2020

Fabio Arturo Iannotti

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21 January 2020

Vincenzo Barrese

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21 January 2020

Maria Roberta Cilio

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21 January 2020

Maurizio Taglialatela

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21 January 2020

language of work or name

English

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publication date

7 December 2010

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Clinical Pharmacology: Advances and Applications

21 January 2020

published in

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21 January 2020

volume

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21 January 2020

page(s)

225-236

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Creative Commons Attribution-NonCommercial 3.0 Unported

21 January 2020

start time

1 December 2010

1 reference

April 2022 Public Data File from Crossref

copyrighted

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Retigabine: in partial seizures

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels

12 July 2018

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12 July 2018

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12 July 2018

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Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability

12 July 2018

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Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity

12 July 2018

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Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy

12 July 2018

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KCNQ4, a K+ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway.

12 July 2018

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The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits

12 July 2018

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12 July 2018

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Retigabine N-glucuronidation and its potential role in enterohepatic circulation

12 July 2018

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KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness

12 July 2018

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12 July 2018

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A potassium channel mutation in neonatal human epilepsy

12 July 2018

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A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family

12 July 2018

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A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns

12 July 2018

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The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells

12 July 2018

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12 July 2018

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D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures

12 July 2018

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12 July 2018

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Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

12 July 2018

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12 July 2018

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12 July 2018

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Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder.

12 July 2018

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The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site

25 September 2018

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25 September 2018

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25 September 2018

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Low expression of Kv7/M channels facilitates intrinsic and network bursting in the developing rat hippocampus

25 September 2018

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In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models

25 September 2018

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Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization.

25 September 2018

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K+ M-current regulates the transition to seizures in immature and adult hippocampus

25 September 2018

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Phenytoin- and carbamazepine-resistant spontaneous bursting in rat entorhinal cortex is blocked by retigabine in vitro

25 September 2018

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25 September 2018

Epilepsy and cognition

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Pre- and postsynaptic activation of M-channels by a novel opener dampens neuronal firing and transmitter release

25 September 2018

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The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels

25 September 2018

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Retigabine and flupirtine exert neuroprotective actions in organotypic hippocampal cultures.

25 September 2018

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Epileptiform activity induced by pharmacologic reduction of M-current in the developing hippocampus in vitro

25 September 2018

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The role of Gilbert's syndrome and frequent NAT2 slow acetylation polymorphisms in the pharmacokinetics of retigabine

25 September 2018

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Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.

25 September 2018

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The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate

25 September 2018

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Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior.

25 September 2018

1 reference

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Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties

25 September 2018

1 reference

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Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study

25 September 2018

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Pharmacokinetic interaction between retigabine and lamotrigine in healthy subjects

25 September 2018

1 reference

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Age-dependent modulation of hippocampal excitability by KCNQ-channels

25 September 2018

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Effects of age and sex on the disposition of retigabine

25 September 2018

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Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine.

25 September 2018

1 reference

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Effects of retigabine on rhythmic synchronous activity of human neocortical slices

25 September 2018

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Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262367

Antioxidant properties of the triaminopyridine, flupirtine

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262367

D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3262367

Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone

25 September 2018

1 reference

12 December 2020

Anticonvulsant properties of D-20443 in genetically epilepsy-prone rats: prediction of clinical response

1 reference

12 December 2020

Correlating the clinical and genetic features of benign familial neonatal seizures (BFNS) with the functional consequences of underlying mutations

1 reference

12 December 2020

Characterization of the K+ channel opening effect of the anticonvulsant retigabine in PC12 cells

1 reference

12 December 2020

Identifiers

DOI

10.2147/CPAA.S15369

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22291509%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22291509%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

PubMed publication ID

22291509

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22291509%20AND%20SRC:MED&resulttype=core&format=json