Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist (Q35689753)

9 August 2017

title

Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist (English)

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9 August 2017

John Ridgway

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Daniel Kirchhofer

object named as

Daniel Kirchhofer

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9 August 2017

Charles Eigenbrot

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9 August 2017

Michael T Lipari

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9 August 2017

Lydia Santell

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9 August 2017

Karen L Billeci

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9 August 2017

Henry R Maun

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9 August 2017

Wendy N Sandoval

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9 August 2017

Paul Moran

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9 August 2017

John Ridgway

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9 August 2017

Robert A Lazarus

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9 August 2017

language of work or name

English

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publication date

19 March 2007

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Proceedings of the National Academy of Sciences of the United States of America

9 August 2017

published in

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9 August 2017

volume

104

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9 August 2017

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9 August 2017

page(s)

5306-5311

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Insights into the structure/function of hepatocyte growth factor/scatter factor from studies with individual domains

9 August 2017

cites work

1 reference

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Structural basis of hepatocyte growth factor/scatter factor and MET signalling

12 July 2018

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c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention

12 July 2018

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Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers

12 July 2018

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Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2.

12 July 2018

1 reference

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Hepatocyte growth factor, its receptor, and their potential value in cancer therapies

12 July 2018

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An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice

12 July 2018

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Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling

12 July 2018

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Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor

12 July 2018

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Met, metastasis, motility and more

12 July 2018

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Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation

12 July 2018

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Serine protease mechanism and specificity

12 July 2018

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Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa

12 July 2018

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Prothrombinase assembly and S1 site occupation restore the catalytic activity of FXa impaired by mutation at the sodium-binding site

12 July 2018

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Scatter-factor and semaphorin receptors: cell signalling for invasive growth

12 July 2018

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Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition

12 July 2018

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12 July 2018

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Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo

12 July 2018

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Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease

12 July 2018

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The PAN module: the N-terminal domains of plasminogen and hepatocyte growth factor are homologous with the apple domains of the prekallikrein family and with a novel domain found in numerous nematode proteins

12 July 2018

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12 July 2018

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Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases

12 July 2018

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Molecular evolution and domain structure of plasminogen-related growth factors (HGF/SF and HGF1/MSP)

12 July 2018

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Scatter factor induces blood vessel formation in vivo

12 July 2018

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Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth

12 July 2018

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Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor

12 July 2018

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Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding

12 July 2018

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A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis

12 July 2018

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The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. II. The binding of the pancreatic trypsin inhibitor and of isoleucine-valine and of sequentially related peptides to trypsinogen and to p-guanidinobenzoate-tryp

12 July 2018

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12 July 2018

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Structural basis of the activation and action of trypsin

12 July 2018

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Role of zymogenicity-determining residues of coagulation factor VII/VIIa in cofactor interaction and macromolecular substrate recognition

21 January 2018

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Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1.

21 January 2018

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An uncleavable form of pro–scatter factor suppresses tumor growth and dissemination in mice

21 January 2018

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Zymogen activation in the streptokinase-plasminogen complex. Ile1 is required for the formation of a functional active site

21 January 2018

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12 December 2020

The transition of bovine trypsinogen to a trypsin-like state upon strong ligand binding. The refined crystal structures of the bovine trypsinogen-pancreatic trypsin inhibitor complex and of its ternary complex with Ile-Val at 1.9 A resolution

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12 December 2020

Identification of regions of bovine factor VII essential for binding to tissue factor

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12 December 2020

Activation of hepatocyte growth factor by two homologous proteases, blood-coagulation factor XIIa and hepatocyte growth factor activator

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12 December 2020

Activating a zymogen without proteolytic processing: mutation of Lys15 and Asn194 activates trypsinogen

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0700184104

1 reference

9 August 2017

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9 August 2017

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