(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction (Q35670379)

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scientific article published on 30 December 2011

Language	Label	Description	Also known as
English	(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction	scientific article published on 30 December 2011

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

(1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

author name string

Yue Pan

1

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9 August 2017

Madina R Gerasimov

2

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9 August 2017

Trine Kvist

3

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9 August 2017

Petrine Wellendorph

4

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9 August 2017

Karsten K Madsen

5

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9 August 2017

Elena Pera

6

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9 August 2017

Hyunbeom Lee

7

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9 August 2017

Arne Schousboe

8

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9 August 2017

Mary Chebib

9

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9 August 2017

Hans Bräuner-Osborne

10

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9 August 2017

Cheryl M Craft

11

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9 August 2017

Jonathan D Brodie

12

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9 August 2017

Wynne K Schiffer

13

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9 August 2017

Stephen L Dewey

14

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9 August 2017

Steven R Miller

15

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9 August 2017

Richard B Silverman

16

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9 August 2017

language of work or name

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publication date

30 December 2011

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9 August 2017

Journal of Medicinal Chemistry

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9 August 2017

55

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9 August 2017

1

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9 August 2017

357-366

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9 August 2017

Electroretinogram Changes in a Pediatric Population With Epilepsy: Is Vigabatrin Acting Alone?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Neurochemicals for the investigation of GABA(C) receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Visual field loss in patients with refractory partial epilepsy treated with vigabatrin: final results from an open-label, observational, multicentre study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Randomized, double-blind, placebo-controlled trial of vigabatrin for the treatment of cocaine dependence in Mexican parolees

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

The four human gamma-aminobutyric acid (GABA) transporters: pharmacological characterization and validation of a highly efficient screening assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Vigabatrin: 2008 update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Taurine deficiency is a cause of vigabatrin-induced retinal phototoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Gamma-vinyl GABA inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats by a non-dopaminergic mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

New treatments for cocaine dependence: a focused review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Molecular targets for antiepileptic drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Structure-activity relationships of selective GABA uptake inhibitors.

1 reference

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12 July 2018

Vigabatrin, the GABA-transaminase inhibitor, damages cone photoreceptors in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Ocular phototoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity

1 reference

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12 July 2018

A pharmacologic strategy for the treatment of nicotine addiction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

A novel strategy for the treatment of cocaine addiction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Effects of pharmacologic increases in brain GABA levels on cocaine-induced changes in extracellular dopamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected].

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Basic aspects of GABA-transaminase in neuropsychiatric disorders.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Chronic toxicity studies with vigabatrin, a GABA-transaminase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Effects of single and multiple increasing doses of vigabatrin on brain gaba metabolism and correlation with vigabatrin plasma concentration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

4-amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

12 July 2018

Registry initiated to characterize vision loss associated with vigabatrin therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

25 September 2018

Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

25 September 2018

Safety and efficacy of gamma-vinyl GABA (GVG) for the treatment of methamphetamine and/or cocaine addiction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

25 September 2018

Acute vigabatrin retinotoxicity in albino rats depends on light but not GABA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

25 September 2018

Design, synthesis, and biological activity of a difluoro-substituted, conformationally rigid vigabatrin analogue as a potent gamma-aminobutyric acid aminotransferase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

25 September 2018

Treating cocaine addiction: from preclinical to clinical trial experience with gamma-vinyl GABA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

25 September 2018

Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

25 September 2018

Systemic administration of 1R,4S-4-amino-cyclopent-2-ene-carboxylic acid, a reversible inhibitor of GABA transaminase, blocks expression of conditioned place preference to cocaine and nicotine in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

25 September 2018

The effects of cyclopentane and cyclopentene analogues of GABA at recombinant GABA(C) receptors

1 reference

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25 September 2018

Multifocal ERG and full-field ERG in patients on long-term vigabatrin medication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

25 September 2018

The effect of gamma-vinyl-GABA on the consumption of concurrently available oral cocaine and ethanol in the rat.

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25 September 2018

Co-administration of gamma-vinyl GABA and cocaine: preclinical assessment of safety

1 reference

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25 September 2018

Gamma-vinyl GABA inhibits methamphetamine, heroin, or ethanol-induced increases in nucleus accumbens dopamine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3257419

25 September 2018

Implication of the GABA(B) receptor in gamma vinyl-GABA's inhibition of cocaine-induced increases in nucleus accumbens dopamine

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25 September 2018

Reduction of Plasma Alanine Aminotransferase During Vigabatrin Treatment

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25 September 2018

Mechanism-based enzyme inactivators

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https://pubmed.ncbi.nlm.nih.gov/22128851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vigabatrin and tiagabine are pharmacologically different drugs. A pre-clinical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/22128851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Separating the retinal electrophysiologic effects of vigabatrin: treatment versus field loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/22128851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperative modulation of [3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines

1 reference

https://pubmed.ncbi.nlm.nih.gov/22128851

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM201231W

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Europe PubMed Central

PubMed publication ID

9 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 August 2017

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