Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114 (Q35608637)

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30 December 2019

title

Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114 (English)

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30 December 2019

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30 December 2019

Irene T Weber

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30 December 2019

Fengling Liu

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30 December 2019

Sofiya Leshchenko

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30 December 2019

Arun K Ghosh

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30 December 2019

John M Louis

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30 December 2019

Robert W Harrison

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30 December 2019

language of work or name

English

0 references

publication date

4 August 2006

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Journal of Molecular Biology

30 December 2019

published in

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30 December 2019

volume

363

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issue

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30 December 2019

page(s)

161-173

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SHELXL: high-resolution refinement

30 December 2019

cites work

1 reference

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Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M.

12 July 2018

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Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.

12 July 2018

1 reference

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TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates

12 July 2018

1 reference

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Beta-lactam compounds as apparently uncompetitive inhibitors of HIV-1 protease

12 July 2018

1 reference

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Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor

12 July 2018

1 reference

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New approaches toward anti-HIV chemotherapy

12 July 2018

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Adaptive inhibitors of the HIV-1 protease

12 July 2018

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Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor

12 July 2018

1 reference

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The CCP4 suite: programs for protein crystallography

12 July 2018

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Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.

12 July 2018

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A graphical user interface to the CCP4 program suite

12 July 2018

1 reference

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Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments

12 July 2018

1 reference

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Polyoxometalate HIV-1 protease inhibitors. A new mode of protease inhibition.

12 July 2018

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Structural and kinetic analysis of drug resistant mutants of HIV-1 protease

12 July 2018

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Further additions to MolScript version 1.4, including reading and contouring of electron-density maps

12 July 2018

1 reference

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Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere

12 July 2018

1 reference

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Inhibitors of HIV-1 protease: a major success of structure-assisted drug design

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781337

Sequence requirements of the HIV-1 protease flap region determined by saturation mutagenesis and kinetic analysis of flap mutants

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1781337

Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases.

12 July 2018

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

12 July 2018

1 reference

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Update of the drug resistance mutations in HIV-1: Fall 2005.

12 July 2018

1 reference

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High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains

25 September 2018

1 reference

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Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site

25 September 2018

1 reference

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N-H...O, O-H...O, and C-H...O hydrogen bonds in protein-ligand complexes: strong and weak interactions in molecular recognition

25 September 2018

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The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

25 September 2018

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Phenotypic and genotypic analysis of clinical HIV-1 isolates reveals extensive protease inhibitor cross-resistance: a survey of over 6000 samples.

25 September 2018

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3-year suppression of HIV viremia with indinavir, zidovudine, and lamivudine

25 September 2018

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25 September 2018

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Overview of the effectiveness of triple combination therapy in antiretroviral-naive HIV-1 infected adults

7 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16962136

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16962136

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Processing of X-ray diffraction data collected in oscillation mode

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16962136

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.JMB.2006.08.007

1 reference

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30 December 2019

1 reference

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30 December 2019

PubMed publication ID

16962136

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16962136%20AND%20SRC:MED&resulttype=core&format=json