Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2 (Q35604279)

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scientific article published on 9 September 2011

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English	Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2	scientific article published on 9 September 2011

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scholarly article

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12 February 2020

Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2 (English)

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12 February 2020

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phosphorylation

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based on heuristic

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1

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12 February 2020

Alexandra C. Newton

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Alexandra C Newton

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12 February 2020

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Matt Niederst

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12 February 2020

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9 September 2011

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12 February 2020

Journal of Biological Chemistry

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12 February 2020

286

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12 February 2020

45

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12 February 2020

39122-39129

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12 February 2020

mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling

1 reference

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12 July 2018

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

1 reference

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12 July 2018

Activation of mTORC2 by Association with the Ribosome

1 reference

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mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells

1 reference

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12 July 2018

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

1 reference

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Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

1 reference

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Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

1 reference

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Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

1 reference

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

1 reference

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

1 reference

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

1 reference

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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

1 reference

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Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization.

1 reference

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12 July 2018

The phosphatase PHLPP controls the cellular levels of protein kinase C

1 reference

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12 July 2018

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo

1 reference

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12 July 2018

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

1 reference

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

1 reference

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12 July 2018

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity

1 reference

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12 July 2018

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

1 reference

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12 July 2018

Growing roles for the mTOR pathway

1 reference

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12 July 2018

An expanding role for mTOR in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234737

12 July 2018

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234737

12 July 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

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12 July 2018

Restraining PI3K: mTOR signalling goes back to the membrane.

1 reference

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12 July 2018

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

1 reference

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12 July 2018

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

1 reference

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12 July 2018

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

1 reference

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12 July 2018

The phosphoinositide 3-kinase pathway

1 reference

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12 July 2018

Role of mTOR in the degradation of IRS-1: regulation of PP2A activity

1 reference

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Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1

1 reference

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A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

1 reference

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

1 reference

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The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation

1 reference

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Carboxyl-terminal phosphorylation regulates the function and subcellular localization of protein kinase C betaII.

1 reference

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1 reference

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Akt activation by growth factors is a multiple-step process: the role of the PH domain

1 reference

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12 July 2018

Mechanism of activation and function of protein kinase B.

1 reference

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Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Calpha.

1 reference

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Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

1 reference

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AKT signaling in normal and malignant cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.278747

21 January 2018

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.278747

21 January 2018

Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism

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Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin.

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21 January 2018

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10.1074/JBC.M111.278747

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21908613%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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12 February 2020

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12 February 2020

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