Clinical relevance of genetic polymorphisms in the human CYP2C9 gene (Q35594567)

9 August 2017

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title

Clinical relevance of genetic polymorphisms in the human CYP2C9 gene (English)

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9 August 2017

Schwarz UI

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9 August 2017

language of work or name

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1 November 2003

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European Journal of Clinical Investigation

9 August 2017

published in

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9 August 2017

volume

33 Suppl 2

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9 August 2017

page(s)

23-30

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Pharmacogenomics: translating functional genomics into rational therapeutics

9 August 2017

cites work

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Impact of CYP2C9 amino acid polymorphisms on glyburide kinetics and on the insulin and glucose response in healthy volunteers

21 January 2018

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Glyburide and glimepiride pharmacokinetics in subjects with different CYP2C9 genotypes

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Catalytic activity of three variants (Ile, Leu, and Thr) at amino acid residue 359 in human CYP2C9 gene and simultaneous detection using single-strand conformation polymorphism analysis

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Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin

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Genetic polymorphisms and functional characterization of the 5'-flanking region of the human CYP2C9 gene: in vitro and in vivo studies

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Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance.

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Structural forms of phenprocoumon and warfarin that are metabolized at the active site of CYP2C9.

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Altered pharmacokinetics of R- and S-acenocoumarol in a subject heterozygous for CYP2C9*3.

21 January 2018

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21 January 2018

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Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers

21 January 2018

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Effects of CYP2C19 and CYP2C9 genetic polymorphisms on the disposition of and blood glucose lowering response to tolbutamide in humans

21 January 2018

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Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in CYP2C91 heterozygotes.

21 January 2018

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CYP2C9 polymorphism: impact on tolbutamide pharmacokinetics and response

21 January 2018

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The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement

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The role of CYP2C9 genotype in the metabolism of diclofenac in vivo and in vitro

21 January 2018

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Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans

21 January 2018

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Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C

21 January 2018

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Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2.

21 January 2018

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The CYP2C9 genotype predicts the blood pressure response to irbesartan: results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA) trial.

21 January 2018

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Frequency of cytochrome P450 CYP2C9 variants in a Turkish population and functional relevance for phenytoin

21 January 2018

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21 January 2018

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Torsemide metabolism by CYP2C9 variants and other human CYP2C subfamily enzymes

21 January 2018

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Genetic polymorphism of the CYP2C subfamily and excessive serum phenytoin concentration with central nervous system intoxication

21 January 2018

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Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population.

21 January 2018

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High frequency of mutations related to impaired CYP2C9 metabolism in a Caucasian population

21 January 2018

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21 January 2018

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Structural flexibility and functional versatility of cytochrome P450 and rapid evolution

21 January 2018

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21 January 2018

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The warfarin-sulfinpyrazone interaction: stereochemical considerations

21 January 2018

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Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications

21 January 2018

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The possession of the CYP2C9*3 allele is associated with low dose requirement of acenocoumarol

21 January 2018

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Normal metabolism of debrisoquine and theophylline in a slow tolbutamide metaboliser

21 January 2018

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Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver

21 January 2018

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Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9*3 allele

21 January 2018

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In vitro inhibition screening of human hepatic P450 enzymes by five angiotensin-II receptor antagonists

21 January 2018

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10.1046/J.1365-2362.33.S2.6.X

21 January 2018

Identifiers

DOI

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9 August 2017

1 reference