Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations (Q35571185)

8 August 2017

title

Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations (English)

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8 August 2017

Ian J Wilson

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Rita Horvath

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David C Samuels

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Mauro Santibanez-Korev

series ordinal

object named as

Mauro Santibanez-Koref

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8 August 2017

Patrick F Chinnery

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8 August 2017

Brendan A I Payne

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8 August 2017

Charlotte A Hateley

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8 August 2017

D Ashley Price

series ordinal

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8 August 2017

language of work or name

English

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publication date

26 June 2011

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8 August 2017

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8 August 2017

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8 August 2017

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8 August 2017

page(s)

806-810

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Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

8 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Coronary aging in HIV-infected patients

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Quantification of mitochondrial DNA mutation load

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

The diversity present in 5140 human mitochondrial genomes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Aging and infectious diseases: workshop on HIV infection and aging: what is known and future research directions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Normal levels of wild-type mitochondrial DNA maintain cytochrome c oxidase activity for two pathogenic mitochondrial DNA mutations but not for m.3243A-->G.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Higher frequency of dementia in older HIV-1 individuals: the Hawaii Aging with HIV-1 Cohort

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Twinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNA

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Premature ageing in mice expressing defective mitochondrial DNA polymerase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Human mitochondrial DNA with large deletions repopulates organelles faster than full-length genomes under relaxed copy number control

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Relaxed replication of mtDNA: A model with implications for the expression of disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Differential accumulations of 4,977 bp deletion in mitochondrial DNA of various tissues in human ageing.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Basic local alignment search tool

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Pyrobayes: an improved base caller for SNP discovery in pyrosequences.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Mitochondrial DNA alterations in blood of the humans exposed to N,N-dimethylformamide

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Is selection required for the accumulation of somatic mitochondrial DNA mutations in post-mitotic cells?

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Changes in mitochondrial DNA as a marker of nucleoside toxicity in HIV-infected patients

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3223397

Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function

26 September 2018

1 reference

12 December 2020

Remarkable infidelity of polymerase gammaA associated with mutations in POLG1 exonuclease domain

1 reference

12 December 2020

Effects of physical activity and age on mitochondrial function

1 reference

12 December 2020

Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle

1 reference

12 December 2020

Low frequency of mtDNA point mutations in patients with PEO associated with POLG1 mutations

1 reference

12 December 2020

Tissue-specific associations between mitochondrial DNA levels and current treatment status in HIV-infected individuals

1 reference

12 December 2020

Mitochondrial (mt)DNA changes in tissue may not be reflected by depletion of mtDNA in peripheral blood mononuclear cells in HIV-infected patients

1 reference

12 December 2020

Reduced aerobic capacity and physical functioning in older HIV-infected men

1 reference

12 December 2020

Prevalence of and risk factors for HIV-associated neuropathy in Melbourne, Australia 1993-2006

1 reference

12 December 2020

HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty

1 reference

12 December 2020

Identifiers

DOI

10.1038/NG.863

1 reference

Dimensions Publication ID

8 August 2017

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8 August 2017

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