Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression (Q35551497)

8 August 2017

title

Beneficial effects of the β-secretase inhibitor GRL-8234 in 5XFAD Alzheimer's transgenic mice lessen during disease progression (English)

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8 August 2017

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Latha Devi

1 reference

8 August 2017

Jordan Tang

series ordinal

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8 August 2017

Masuo Ohno

series ordinal

1 reference

8 August 2017

publication date

1 January 2015

1 reference

Current Alzheimer Research

8 August 2017

published in

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8 August 2017

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8 August 2017

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8 August 2017

page(s)

13-21

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Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease

8 August 2017

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12 July 2018

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7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease

12 July 2018

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Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice

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Phospho-eIF2α Level Is Important for Determining Abilities of BACE1 Reduction to Rescue Cholinergic Neurodegeneration and Memory Defects in 5XFAD Mice

12 July 2018

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12 July 2018

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Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice

12 July 2018

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12 July 2018

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12 July 2018

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Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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12 July 2018

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BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

12 July 2018

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Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

12 July 2018

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Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

12 July 2018

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Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge

12 July 2018

1 reference

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Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

12 July 2018

1 reference

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12 July 2018

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The neurobiological basis of spontaneous alternation

12 July 2018

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The beta-secretase, BACE: a prime drug target for Alzheimer's disease

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414026

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

12 July 2018

1 reference

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Alzheimer's disease: the amyloid cascade hypothesis

12 July 2018

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A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice

12 July 2018

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Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice

26 September 2018

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PKC ε Activation Prevents Synaptic Loss, Aβ Elevation, and Cognitive Deficits in Alzheimer's Disease Transgenic Mice

26 September 2018

1 reference

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Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414026

alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.

26 September 2018

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Memory deficits and neurochemical changes induced by C-reactive protein in rats: implication in Alzheimer's disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414026

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414026

Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414026

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414026

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414026

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414026

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4414026

10.2174/1567205012666141218125042

26 September 2018

Identifiers

DOI

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8 August 2017

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8 August 2017

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