Proteasome malfunction activates macroautophagy in the heart (Q35536300)

8 August 2017

title

Proteasome malfunction activates macroautophagy in the heart (English)

1 reference

8 August 2017

Qingwen Zheng

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8 August 2017

Huabo Su

series ordinal

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8 August 2017

Zongwen Tian

series ordinal

1 reference

8 August 2017

Xuejun Wang

series ordinal

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8 August 2017

publication date

28 July 2011

1 reference

American journal of cardiovascular disease

8 August 2017

published in

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8 August 2017

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8 August 2017

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8 August 2017

page(s)

214-226

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Autophagy and p62 in cardiac proteinopathy.

8 August 2017

cites work

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Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts

12 July 2018

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p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

12 July 2018

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12 July 2018

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

12 July 2018

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The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective

12 July 2018

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Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

12 July 2018

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12 July 2018

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Misfolded proteins partition between two distinct quality control compartments

12 July 2018

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Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy

12 July 2018

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12 July 2018

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Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

12 July 2018

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Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

12 July 2018

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Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

12 July 2018

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In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases

12 July 2018

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Autophagosome formation: core machinery and adaptations

12 July 2018

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

12 July 2018

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The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

12 July 2018

1 reference

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Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II).

12 July 2018

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Heart failure and protein quality control

12 July 2018

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Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival.

12 July 2018

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The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor

12 July 2018

1 reference

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Autophagy is activated for cell survival after endoplasmic reticulum stress

12 July 2018

1 reference

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Protein degradation by the 26S proteasome system in the normal and stressed myocardium

12 July 2018

1 reference

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Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes

12 July 2018

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Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes

12 July 2018

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Autophagy and its possible roles in nervous system diseases, damage and repair

12 July 2018

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

12 July 2018

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

12 July 2018

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Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts

12 July 2018

1 reference

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

12 July 2018

1 reference

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A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

The mammalian unfolded protein response

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

12 July 2018

1 reference

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Autophagy: a regulated bulk degradation process inside cells

12 July 2018

1 reference

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Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditions

12 July 2018

1 reference

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Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells

12 July 2018

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Potent and selective inhibitors of the proteasome: dipeptidyl boronic acids

12 July 2018

1 reference

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Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis

12 July 2018

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Proteasome inhibitors: valuable new tools for cell biologists

12 July 2018

1 reference

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Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

Optimal determination of heart tissue 26S-proteasome activity requires maximal stimulating ATP concentrations.

12 July 2018

1 reference

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ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

Aberrant protein aggregation is essential for a mutant desmin to impair the proteolytic function of the ubiquitin-proteasome system in cardiomyocytes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

Endoplasmic reticulum stress compromises the ubiquitin-proteasome system

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

Involvement of macroautophagy in the dissolution of neuronal inclusions

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

Role of proteasomes in the degradation of short-lived proteins in human fibroblasts under various growth conditions

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

Involvement of lysosomes in the pathogenesis of CAG repeat diseases

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3211094

Proteasome inhibition measurements: clinical application

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22081794

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

PMC publication ID

3211094

1 reference

8 August 2017

1 reference