Dexfenfluramine. A review of its pharmacological properties and therapeutic potential in obesity (Q35329220)

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scientific article published on May 1, 1992

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English	Dexfenfluramine. A review of its pharmacological properties and therapeutic potential in obesity	scientific article published on May 1, 1992

Statements

instance of

scholarly article

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stated in

Europe PubMed Central

PubMed publication ID

1379149

retrieved

7 August 2017

review article

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stated in

Europe PubMed Central

title

Dexfenfluramine. A review of its pharmacological properties and therapeutic potential in obesity (English)

1 reference

stated in

Europe PubMed Central

PubMed publication ID

1379149

retrieved

7 August 2017

main subject

obesity

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based on heuristic

inferred from title

author name string

McTavish D

series ordinal

1

1 reference

stated in

Europe PubMed Central

PubMed publication ID

1379149

retrieved

7 August 2017

D. McTavish

series ordinal

1

1 reference

stated in

Europe PubMed Central

PubMed publication ID

1379149

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1379149

retrieved

20 September 2022

R. C. Heel

series ordinal

2

1 reference

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Europe PubMed Central

PubMed publication ID

1379149

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1379149

retrieved

20 September 2022

language of work or name

English

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National Center for Biotechnology Information

PubMed publication ID

1379149

reference URL

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1379149

retrieved

20 September 2022

publication date

1 May 1992

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stated in

Europe PubMed Central

PubMed publication ID

1379149

retrieved

7 August 2017

published in

Drugs

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Europe PubMed Central

PubMed publication ID

1379149

retrieved

7 August 2017

volume

43

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Europe PubMed Central

PubMed publication ID

1379149

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7 August 2017

issue

5

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Europe PubMed Central

PubMed publication ID

1379149

retrieved

7 August 2017

page(s)

713-733

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Europe PubMed Central

PubMed publication ID

1379149

retrieved

7 August 2017

cites work

Drugs that enhance central serotoninergic transmission diminish elective carbohydrate consumption by rats

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Carbohydrate craving. Relationship between carbohydrate intake and disorders of mood

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Fenfluramine administered systemically or locally increases extracellular serotonin in the lateral hypothalamus as measured by microdialysis

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Serotonin manipulations and the structure of feeding behaviour

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Effect of dexfenfluramine on body weight set-point: study in the rat with hoarding behaviour.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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inferred from PubMed ID database lookup

Progress in assessing the role of serotonin in the control of food intake

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Effect of D-fenfluramine on serotonin release in brains of anaesthetized rats

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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The interaction of metergoline, a 5-HT receptor blocker, and dexfenfluramine in human feeding

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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d-Fenfluramine selectively decreases carbohydrate but not protein intake in obese subjects

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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inferred from PubMed ID database lookup

Permanent administration of d-fenfluramine in rats: paradoxical effects

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Dopaminergic and serotoninergic anorectics differentially antagonize insulin- and 2-DG-induced hyperphagia

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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inferred from PubMed ID database lookup

Modulation of the thermic effect of food by fenfluramine

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Lipostatic and ischymetric mechanisms originate dexfenfluramine-induced anorexia.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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D-, L- and DL-fenfluramine cause long-lasting depletions of serotonin in rat brain

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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inferred from PubMed ID database lookup

Long term actions of d-fenfluramine in two rat models of obesity. I Sustained reductions in body weight and adiposity without depletion of brain serotonin

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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inferred from PubMed ID database lookup

Feeding and satiation observed in the runway: the effects of d-amphetamine and d-fenfluramine compared

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Effects of d-amphetamine and d-fenfluramine on performance of rats in a food maze.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Different effects of fenfluramine isomers and metabolites on extracellular 5-HIAA in nucleus accumbens and hippocampus of freely moving rats

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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inferred from PubMed ID database lookup

Carbohydrate craving, obesity and brain serotonin.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Effects of repeated administration of serotonergic agonists on diet selection and body weight in rats

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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8-OH-DPAT-induced hyperphagia: its neural basis and possible therapeutic relevance

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Chlorophenylpiperazine: a central serotonin agonist causing powerful anorexia in rats

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Treatment of seasonal depression with d-fenfluramine

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Species differences in the kinetics and metabolism of fenfluramine isomers

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Differential effects of d-fenfluramine and p-chloroamphetamine on H7512-induced depletion of 5-hydroxytryptamine and dopamine in the rat brain

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Is receptor activation involved in the mechanism by which (+)-fenfluramine and (+)-norfenfluramine deplete 5-hydroxytryptamine in the rat brain?

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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8-Hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicits eating in free-feeding rats by acting on central serotonin neurons

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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inferred from PubMed ID database lookup

Fenfluramine and brain serotonin

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Carbohydrate cravings: a disorder of food intake and mood

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Dexfenfluramine neurotoxicity in brains of non-human primates

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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The ability of certain anorexic drugs to suppress food consumption depends on the nutrient composition of the test diet

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Decreased incorporation of glucose into lipids and increased lactate production by adipose tissue after long-term treatment of rats with D-fenfluramine

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Neurochemical mechanism of action of drugs which modify feeding via the serotoninergic system

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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d-Fenfluramine selectively suppresses carbohydrate snacking by obese subjects

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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The role of serotonin in eating disorders

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Reduction of food intake by manipulation of central serotonin. Current experimental results

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Food intake and selection pattern of rats treated with dexfenfluramine, fluoxetine and RU 24969.

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Metabolic mechanism of the anorectic and leptogenic effects of the serotonin agonist fenfluramine

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Prolonged use of a very low calorie diet (Cambridge diet) in massively obese patients attending an obesity clinic: safety, efficacy and additional benefit from dexfenfluramine

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Overweight is risking fate. Definition, classification, prevalence, and risks

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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d- and l-isomers of fenfluramine differ markedly in their interaction with brain serotonin and catecholamines in the rat.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Pharmacokinetics of fenfluramine and norfenfluramine in volunteers given D- and DL-fenfluramine for 15 days

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Hypothalamic serotonin: pharmacological, biochemical, and behavioral analyses of its feeding-suppressive action

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Effect of 6 months therapy with dexfenfluramine in obese patients: studies in the United Kingdom

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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inferred from PubMed ID database lookup

Enhancement of the thermic effect of food by d-fenfluramine

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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inferred from PubMed ID database lookup

International trial of long-term dexfenfluramine in obesity.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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d-Fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Effect of dexfenfluramine on gastric emptying of a mixed solid-liquid meal in obese subjects

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Effect of naloxone and naltrexone on the development of satiation measured in the runway: comparisons with d-amphetamine and d-fenfluramine.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Eating caused by neuropeptide-Y injection in the paraventricular hypothalamus: response to (+)-fenfluramine and (+)-amphetamine in rats

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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The role of putative 5-HT1A and 5-HT1B receptors in the control of feeding in rats

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Tolerance to fenfluramine anorexia: fact or fiction?

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Role of 5-HT receptors in the effect of d-fenfluramine on gastric emptying and feeding behaviour as examined in the runway test

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Weight gain and withdrawal symptoms after smoking cessation: a preventive intervention using d-fenfluramine

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Characterization of high affinity and stereospecific [ (3)H ]d- fenfluramine binding to rat brain

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Efficacy and safety of dexfenfluramine in obese patients: a multicenter study.

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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On the mechanism of action of dexfenfluramine: effect on alliesthesia and appetite motivation in lean and obese subjects

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Anorectic agents lower a body weight set point

1 reference

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Management strategies for weight control. Eating, exercise and behaviour

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Sensitivity of the appetite control system in obese subjects to nutritional and serotoninergic challenges

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Effect of (+)- or (−)-enantiomers of fenfluramine or norfenfluramine on nutrient selection by rats

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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D-Fenfluramine and D-norfenfluramine reduce food intake by acting on different serotonin mechanisms in the rat brain

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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inferred from PubMed ID database lookup

Brain serotonin and carbohydrate craving in obesity

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

retrieved

12 December 2020

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Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the rat.

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

retrieved

12 December 2020

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Fenfluramine and fluoxetine spare protein consumption while suppressing caloric intake by rats

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Pulmonary hypertension and dexfenfluramine

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Repeated treatment with d-fenfluramine or metergoline alters cortex binding of 3H-serotonin and serotenergic sensitivity in rats

1 reference

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reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

retrieved

12 December 2020

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inferred from PubMed ID database lookup

Characteristics of feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT).

1 reference

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Effects of methiothepin on changes in brain serotonin release induced by repeated administration of high doses of anorectic serotoninergic drugs

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/1379149

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12 December 2020

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Identifiers

DOI

10.2165/00003495-199243050-00007

1 reference

stated in

Europe PubMed Central

PubMed publication ID

1379149

retrieved

7 August 2017

Dimensions Publication ID

1043108189

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Fatcat ID

release_43r4beqckvag5eur2eeeblvwmu

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Fatcat

reference URL

https://api.fatcat.wiki/v0/release/43r4beqckvag5eur2eeeblvwmu

retrieved

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1379149

1 reference

stated in

Europe PubMed Central

PubMed publication ID

1379149

retrieved

7 August 2017

 

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