The hybrid state of tRNA binding is an authentic translation elongation intermediate (Q35205553)

7 August 2017

title

The hybrid state of tRNA binding is an authentic translation elongation intermediate (English)

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7 August 2017

Silke Dorner

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7 August 2017

Julie L Brunelle

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7 August 2017

Divya Sharma

series ordinal

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7 August 2017

Rachel Green

series ordinal

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7 August 2017

language of work or name

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26 February 2006

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Nature Structural & Molecular Biology

7 August 2017

published in

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

234-241

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describes a project that uses

7 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1687179/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

The interaction between C75 of tRNA and the A loop of the ribosome stimulates peptidyl transferase activity

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An active role for tRNA in decoding beyond codon:anticodon pairing

28 July 2018

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Initiation of protein synthesis in bacteria

28 July 2018

1 reference

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tRNA dynamics on the ribosome during translation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

EF-G-independent reactivity of a pre-translocation-state ribosome complex with the aminoacyl tRNA substrate puromycin supports an intermediate (hybrid) state of tRNA binding

28 July 2018

1 reference

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Locking and unlocking of ribosomal motions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

Structural insights into peptide bond formation

28 July 2018

1 reference

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Crystal structure of the ribosome at 5.5 A resolution

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

The structural basis of ribosome activity in peptide bond synthesis

28 July 2018

1 reference

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Intact aminoacyl-tRNA is required to trigger GTP hydrolysis by elongation factor Tu on the ribosome

28 July 2018

1 reference

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Mutations at nucleotides G2251 and U2585 of 23 S rRNA perturb the peptidyl transferase center of the ribosome

28 July 2018

1 reference

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Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome

28 July 2018

1 reference

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A base pair between tRNA and 23S rRNA in the peptidyl transferase centre of the ribosome

28 July 2018

1 reference

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28 July 2018

Initiator transfer RNAs

1 reference

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Three tRNA binding sites on Escherichia coli ribosomes

28 July 2018

1 reference

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Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates

28 July 2018

1 reference

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Intermediate states in the movement of transfer RNA in the ribosome

28 July 2018

1 reference

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Nucleotides in yeast tRNAPhe required for the specific recognition by its cognate synthetase

28 July 2018

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Binding of the 3' terminus of tRNA to 23S rRNA in the ribosomal exit site actively promotes translocation

28 July 2018

1 reference

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Extension inhibition analysis of translation initiation complexes

28 July 2018

1 reference

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Affinity purification of in vivo-assembled ribosomes for in vitro biochemical analysis

28 July 2018

1 reference

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Guanine-nucleotide exchange on ribosome-bound elongation factor G initiates the translocation of tRNAs

26 September 2018

1 reference

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Conformational changes of the small ribosomal subunit during elongation factor G-dependent tRNA-mRNA translocation

26 September 2018

1 reference

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Substrate-assisted catalysis of peptide bond formation by the ribosome

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

The active site of the ribosome is composed of two layers of conserved nucleotides with distinct roles in peptide bond formation and peptide release

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

Ribosomal translocation: sparsomycin pushes the button

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

An elongation factor G-induced ribosome rearrangement precedes tRNA-mRNA translocation

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

Catalysis of ribosomal translocation by sparsomycin

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

Rapid kinetic analysis of EF-G-dependent mRNA translocation in the ribosome

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

Coupling of GTP hydrolysis by elongation factor G to translocation and factor recycling on the ribosome

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

GTPase activation of elongation factors Tu and G on the ribosome

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

Accurate translocation of mRNA by the ribosome requires a peptidyl group or its analog on the tRNA moving into the 30S P site.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

Conformational changes in the ribosome induced by translational miscoding agents.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

Energetic contribution of tRNA hybrid state formation to translocation catalysis on the ribosome.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1687179

Translocation in Protein Synthesis: A Hybrid Structure Model

26 September 2018

1 reference

Action of Sparsomycin on Ribosome-catalysed Peptidyl Transfer

21 January 2018

1 reference

Effect of buffer conditions on the position of tRNA on the 70 S ribosome as visualized by cryoelectron microscopy

21 January 2018

1 reference

Base-pairing between 23S rRNA and tRNA in the ribosomal A site

31 March 2020

1 reference

The Conformational Properties of Elongation Factor G and the Mechanism of Translocation

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB1060

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Dimensions Publication ID

7 August 2017

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7 August 2017

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