Development of gene therapy for treatment of age-related macular degeneration (Q35192906)

Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression

21 January 2018

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Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor

21 January 2018

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Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy

21 January 2018

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Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders

21 January 2018

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Novel adeno-associated virus serotypes efficiently transduce murine photoreceptors

21 January 2018

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Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

21 January 2018

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Stable gene transfer to muscle using non-integrating lentiviral vectors

21 January 2018

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A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8

21 January 2018

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Suppression of laser-induced choroidal neovascularization by nontargeted siRNA.

21 January 2018

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Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model

21 January 2018

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Polyethylene glycol-modified pigment epithelial-derived factor: new prospects for treatment of retinal neovascularization

21 January 2018

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Effect of gene therapy on visual function in Leber's congenital amaurosis

21 January 2018

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Ocular gene delivery using lentiviral vectors

21 January 2018

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MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

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A large U3 deletion causes increased in vivo expression from a nonintegrating lentiviral vector

21 January 2018

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The effects of PEDF on cancer biology: mechanisms of action and therapeutic potential

21 January 2018

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Pigment epithelium-derived factor in the monkey retinal pigment epithelium and interphotoreceptor matrix: apical secretion and distribution.

21 January 2018

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The privileged immunity of immune privileged organs: the case of the eye.

21 January 2018

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AAV2 gene therapy readministration in three adults with congenital blindness.

21 January 2018

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Small interfering RNAs induce target-independent inhibition of tumor growth and vasculature remodeling in a mouse model of hepatocellular carcinoma

21 January 2018

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Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

21 January 2018

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Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent

21 January 2018

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Safety and biodistribution of an equine infectious anemia virus-based gene therapy, RetinoStat(®), for age-related macular degeneration

21 January 2018

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Therapeutic targets in age-related macular disease

21 January 2018

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Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation

21 January 2018

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Minimizing variables among hairpin-based RNAi vectors reveals the potency of shRNAs

21 January 2018

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Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo

21 January 2018

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Inhibition of oxygen-induced retinopathy in RTP801-deficient mice

21 January 2018

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Principles of microRNA-target recognition

21 January 2018

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Evaluation of lateral spread of transgene expression following subretinal AAV-mediated gene delivery in dogs

21 January 2018

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A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

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Ocular neovascularization

21 January 2018

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Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial

21 January 2018

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Inhibition of choroidal neovascularization by adenovirus-mediated delivery of short hairpin RNAs targeting VEGF as a potential therapy for AMD.

21 January 2018

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Very low density lipoprotein receptor, a negative regulator of the wnt signaling pathway and choroidal neovascularization

21 January 2018

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Polycistronic RNA polymerase II expression vectors for RNA interference based on BIC/miR-155.

21 January 2018

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Interleukin 6 induces the expression of vascular endothelial growth factor

21 January 2018

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Targeted genome modifications using integrase-deficient lentiviral vectors

21 January 2018

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Protective Antiviral Immunity Conferred by a Nonintegrative Lentiviral Vector-Based Vaccine

21 January 2018

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Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.

21 January 2018

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Inner limiting membrane barriers to AAV-mediated retinal transduction from the vitreous

21 January 2018

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In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous

21 January 2018

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Pigment epithelium-derived factor: a potent inhibitor of angiogenesis

21 January 2018

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Wnt/beta-catenin signaling regulates cytokine-induced human inducible nitric oxide synthase expression by inhibiting nuclear factor-kappaB activation in cancer cells

21 January 2018

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Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system

21 January 2018

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Macrophages in proliferative vitreoretinopathy and proliferative diabetic retinopathy: differentiation of subpopulations

21 January 2018

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Off-target effects by siRNA can induce toxic phenotype

21 January 2018

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21 January 2018

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

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Meta-analysis of genome scans of age-related macular degeneration

21 January 2018

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Angiogenesis in cancer, vascular, rheumatoid and other disease

21 January 2018

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Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss

21 January 2018

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A Hemodynamic Model of the Pathogenesis of Age-related Macular Degeneration

21 January 2018

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Seven new loci associated with age-related macular degeneration

21 January 2018

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Periocular gene transfer of sFlt-1 suppresses ocular neovascularization and vascular endothelial growth factor-induced breakdown of the blood-retinal barrier

21 January 2018

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Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia.

21 January 2018

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Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific vascular endothelial growth factor mutants

21 January 2018

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Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration

21 January 2018

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The Wnt/Wg signal transducer beta-catenin controls fibronectin expression

21 January 2018

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Pegaptanib for neovascular age-related macular degeneration

21 January 2018

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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

21 January 2018

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Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver

21 January 2018

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Correlation of histologic 2-dimensional reconstruction and confocal scanning laser microscopic imaging of choroidal neovascularization in eyes with age-related maculopathy

21 January 2018

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Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration.

21 January 2018

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Inhibition of experimental choroidal neovascularization in mice by anti-VEGFA/VEGFR2 or non-specific siRNA.

21 January 2018

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The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo

21 January 2018

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Vasculotropin/vascular endothelial growth factor is an autocrine growth factor for human retinal pigment epithelial cells cultured in vitro

21 January 2018

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An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration

21 January 2018

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Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6

21 January 2018

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An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

21 January 2018

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Aging: a theory based on free radical and radiation chemistry

21 January 2018

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Regulation of macrophage production of vascular endothelial growth factor (VEGF) by hypoxia and transforming growth factor beta-1.

21 January 2018

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VEGF-A splicing: the key to anti-angiogenic therapeutics?

21 January 2018

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MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling.

21 January 2018

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Treatment of leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial

21 January 2018

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siRNA target site secondary structure predictions using local stable substructures

21 January 2018

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Mouse model of subretinal neovascularization with choroidal anastomosis

21 January 2018

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Sibling correlations and segregation analysis of age-related maculopathy: the Beaver Dam Eye Study.

21 January 2018

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Ranibizumab for treatment of neovascular age-related macular degeneration: a phase I/II multicenter, controlled, multidose study

21 January 2018

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Reliable prediction of Drosha processing sites improves microRNA gene prediction

21 January 2018

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Anatomy and Physiology of the Retina

21 January 2018

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VEGF-Trap: a VEGF blocker with potent antitumor effects

21 January 2018

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The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease

21 January 2018

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Experimental subretinal neovascularization is inhibited by adenovirus-mediated soluble VEGF/flt-1 receptor gene transfection: a role of VEGF and possible treatment for SRN in age-related macular degeneration

21 January 2018

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PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets.

21 January 2018

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The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA.

21 January 2018

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RNAa is conserved in mammalian cells

21 January 2018

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VEGF receptor blockade markedly reduces retinal microglia/macrophage infiltration into laser-induced CNV.

21 January 2018

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Macromolecular diffusion characteristics of ageing human Bruch's membrane: implications for age-related macular degeneration (AMD).

21 January 2018

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Adeno-associated vector (type 8)-mediated expression of soluble Flt-1 efficiently inhibits neovascularization in a murine choroidal neovascularization model

21 January 2018

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Gene therapy for leber congenital amaurosis caused by RPE65 mutations: safety and efficacy in 15 children and adults followed up to 3 years

21 January 2018

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Equine infectious anemia viral vector-mediated codelivery of endostatin and angiostatin driven by retinal pigmented epithelium-specific VMD2 promoter inhibits choroidal neovascularization.

21 January 2018

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MicroRNA-restricted transgene expression in the retina

21 January 2018

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Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

21 January 2018

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Retinoic acid from retinal pigment epithelium induces T regulatory cells

21 January 2018

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Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor

21 January 2018

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21 January 2018

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21 January 2018

Genomics of microRNA.

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The epidemiology of age-related macular degeneration

21 January 2018

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The epidemiology of retinal reticular drusen

21 January 2018

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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

21 January 2018

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Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3.

21 January 2018

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Increased expression of angiogenic growth factors in age-related maculopathy

21 January 2018

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Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease

21 January 2018

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Targeted deletion of Vegfa in adult mice induces vision loss

21 January 2018

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Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys

21 January 2018

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Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates.

21 January 2018

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Comparison between the repression potency of siRNA targeting the coding region and the 3'-untranslated region of mRNA.

21 January 2018

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Matrix metalloproteinase-9 contributes to choroidal neovascularization

21 January 2018

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Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice.

21 January 2018

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VEGF162, a new heparin-binding vascular endothelial growth factor splice form that is expressed in transformed human cells

21 January 2018

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Clinical and histological aspects of CNV formation: studies in an animal model

21 January 2018

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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

21 January 2018

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The nuclear RNase III Drosha initiates microRNA processing

21 January 2018

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MicroRNA genes are transcribed by RNA polymerase II

21 January 2018

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New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites

21 January 2018

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Laser photocoagulation enhances adeno-associated viral vector transduction of mouse retina

21 January 2018

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Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183.

21 January 2018

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Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: initial characterization

21 January 2018

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Defining the optimal parameters for hairpin-based knockdown constructs

21 January 2018

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Preclinical Safety Evaluation of AAV2-sFLT01— A Gene Therapy for Age-related Macular Degeneration

21 January 2018

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Safety and efficacy of gene transfer for Leber's congenital amaurosis

21 January 2018

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Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

21 January 2018

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Extracellular phosphorylation converts pigment epithelium-derived factor from a neurotrophic to an antiangiogenic factor

21 January 2018

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21 January 2018

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Variation in complement factor 3 is associated with risk of age-related macular degeneration

21 January 2018

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Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design.

21 January 2018

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Potency of siRNA versus shRNA mediated knockdown in vivo

21 January 2018

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Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi

21 January 2018

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Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study

21 January 2018

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Pigment Epithelium-Derived Factor Gene Therapy Targeting Retinal Ganglion Cell Injuries: Neuroprotection against Loss of Function in Two Animal Models

21 January 2018

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Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization

21 January 2018

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Inhibition of choroidal neovascularization via brief subretinal exposure to a newly developed lentiviral vector pseudotyped with Sendai viral envelope proteins

21 January 2018

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Regulation of VEGF expression in human retinal cells by cytokines: Implications for the role of inflammation in age‐related macular degeneration

21 January 2018

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Uncontrolled zinc- and copper-induced oligomerisation of the human complement regulator factor H and its possible implications for function and disease.

21 January 2018

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Assessment of ocular transduction using single-stranded and self-complementary recombinant adeno-associated virus serotype 2/8.

21 January 2018

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Differential expression of VEGF isoforms in mouse during development and in the adult

21 January 2018

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Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

21 January 2018

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Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia

21 January 2018

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Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor

21 January 2018

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Increased expression of VEGF in retinal pigmented epithelial cells is not sufficient to cause choroidal neovascularization.

21 January 2018

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Identification of a Novel Inhibitor of the Canonical Wnt Pathway

21 January 2018

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Mechanism of inflammation in age-related macular degeneration

21 January 2018

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Novel anti-VEGF chimeric molecules delivered by AAV vectors for inhibition of retinal neovascularization.

21 January 2018

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Animal models of age related macular degeneration

21 January 2018

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High-efficiency transduction of the mouse retina by tyrosine-mutant AAV serotype vectors

21 January 2018

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MicroRNA-373 induces expression of genes with complementary promoter sequences

21 January 2018

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miR-24 regulates apoptosis by targeting the open reading frame (ORF) region of FAF1 in cancer cells

21 January 2018

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Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity

21 January 2018

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Marked inhibition of retinal neovascularization in rats following soluble-flt-1 gene transfer

21 January 2018

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Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathy

21 January 2018

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Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors

21 January 2018

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An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris

21 January 2018

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Local RNA target structure influences siRNA efficacy: systematic analysis of intentionally designed binding regions

21 January 2018

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Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium

21 January 2018

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Familial aggregation of age-related maculopathy

21 January 2018

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Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

21 January 2018

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Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1.

21 January 2018

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Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis

21 January 2018

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Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis

21 January 2018

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Endothelial tip cells in ocular angiogenesis: potential target for anti-angiogenesis therapy

21 January 2018

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Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration

21 January 2018

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Macrophages in neovascular age-related macular degeneration: friends or foes?

21 January 2018

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Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor

21 January 2018

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Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease.

21 January 2018

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Pigment epithelium-derived factor receptor (PEDF-R): a plasma membrane-linked phospholipase with PEDF binding affinity

21 January 2018

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Inhibition of B-cell activation by retinal pigment epithelium

21 January 2018

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Versatility of AAV vectors for retinal gene transfer

21 January 2018

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Three-year follow-up after unilateral subretinal delivery of adeno-associated virus in patients with Leber congenital Amaurosis type 2

21 January 2018

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Systematic review and meta-analysis of the association between complement factor H Y402H polymorphisms and age-related macular degeneration

21 January 2018

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Smoking and age-related macular degeneration: a review of association.

21 January 2018

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Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model

21 January 2018

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Retinoic acid and dexamethasone regulate the expression of PEDF in retinal and endothelial cells

21 January 2018

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Pigment epithelium-derived factor inhibits oxidative stress-induced cell death by activation of extracellular signal-regulated kinases in cultured retinal pigment epithelial cells

21 January 2018

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Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

21 January 2018

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Mitochondrial diseases in man and mouse

21 January 2018

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General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

21 January 2018

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Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage

21 January 2018

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Recombinant adeno-associated virus serotype 4 mediates unique and exclusive long-term transduction of retinal pigmented epithelium in rat, dog, and nonhuman primate after subretinal delivery

21 January 2018

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Levels of vascular endothelial growth factor are elevated in the vitreous of patients with subretinal neovascularisation

21 January 2018

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Complement C3 variant and the risk of age-related macular degeneration

21 January 2018

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Pigment epithelial growth factor suppresses inflammation by modulating macrophage activation.

21 January 2018

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Immunosuppressive properties of the pigmented epithelial cells and the subretinal space

21 January 2018

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Current concepts in the pathogenesis of age-related macular degeneration

21 January 2018

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Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses

21 January 2018

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An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi

21 January 2018

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Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection

21 January 2018

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Prevalence and significance of subretinal drusenoid deposits (reticular pseudodrusen) in age-related macular degeneration

21 January 2018

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Induction of an interferon response by RNAi vectors in mammalian cells

21 January 2018

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