Anthrax toxin: structures, functions and tumour targeting (Q35184740)

7 August 2017

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title

Anthrax toxin: structures, functions and tumour targeting (English)

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7 August 2017

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Stephen H Leppla

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7 August 2017

Thomas H Bugge

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7 August 2017

Shihui Liu

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7 August 2017

Rebecca L Schubert

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7 August 2017

language of work or name

English

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publication date

1 August 2003

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Expert Opinion on Biological Therapy

7 August 2017

published in

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

843-853

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Crystal structure of the anthrax toxin protective antigen

7 August 2017

cites work

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Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin

21 January 2018

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Identification of the cellular receptor for anthrax toxin

21 January 2018

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Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor

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Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor

21 January 2018

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Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages

21 January 2018

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The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen

21 January 2018

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Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen

21 January 2018

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Involvement of domain 3 in oligomerization by the protective antigen moiety of anthrax toxin

21 January 2018

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Point mutations in anthrax protective antigen that block translocation

21 January 2018

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Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

21 January 2018

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Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization

21 January 2018

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A dominant negative mutant of Bacillus anthracis protective antigen inhibits anthrax toxin action in vivo

21 January 2018

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Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity

21 January 2018

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Designing a polyvalent inhibitor of anthrax toxin

21 January 2018

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Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways

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Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin

21 January 2018

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Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase

21 January 2018

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Potent antitumor activity of a urokinase-activated engineered anthrax toxin

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Cancer statistics, 2003.

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Immunotoxins in cancer therapy

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Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors

21 January 2018

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Genes expressed in human tumor endothelium

21 January 2018

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Stoichiometry of anthrax toxin complexes

21 January 2018

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Characterization of membrane translocation by anthrax protective antigen

21 January 2018

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Biochemical and physiological changes induced by anthrax lethal toxin in J774 macrophage-like cells

21 January 2018

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Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells

21 January 2018

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Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo

21 January 2018

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Targeting HIV proteins to the major histocompatibility complex class I processing pathway with a novel gp120-anthrax toxin fusion protein

21 January 2018

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Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein

21 January 2018

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The development and therapeutic potential of protein kinase inhibitors

21 January 2018

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Tumor cell interactions with the extracellular matrix during invasion and metastasis

21 January 2018

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The plasminogen activation system in tumor growth, invasion, and metastasis

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Proteolytic remodeling of extracellular matrix

21 January 2018

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Changing views of the role of matrix metalloproteinases in metastasis

21 January 2018

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Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation

21 January 2018

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Matrix metalloproteinases: a review

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RECKing MMP function: implications for cancer development

21 January 2018

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21 January 2018

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Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor

21 January 2018

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The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type

21 January 2018

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Optimal Subsite Occupancy and Design of a Selective Inhibitor of Urokinase

21 January 2018

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Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator

21 January 2018

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Receptor-independent role of urokinase-type plasminogen activator in pericellular plasmin and matrix metalloproteinase proteolysis during vascular wound healing in mice

21 January 2018

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Dominant-Negative Mutants of a Toxin Subunit: An Approach to Therapy of Anthrax

21 January 2018

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21 January 2018

Identifiers

DOI

10.1517/14712598.3.5.843

1 reference

7 August 2017

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