The lipid and non-lipid effects of statins (Q35153749)

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7 January 2021

Platelet Deposition on Eroded Vessel Walls at a Stenotic Shear Rate Is Inhibited by Lipid-Lowering Treatment With Atorvastatin

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7 January 2021

Treatment with atorvastatin to the National Cholesterol Educational Program goal versus 'usual' care in secondary coronary heart disease prevention. The GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) study

1 reference

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7 January 2021

Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein

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7 January 2021

Do statins cause cancer? A meta-analysis of large randomized clinical trials

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7 January 2021

Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina

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7 January 2021

Use of statins and blood pressure control in treated hypertensive patients with hypercholesterolemia

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7 January 2021

A second gene for peroxisomal HMG-CoA reductase? A genomic reassessment

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7 January 2021

Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease

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7 January 2021

HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis

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7 January 2021

Reduction in cardiovascular events during pravastatin therapy. Pooled analysis of clinical events of the Pravastatin Atherosclerosis Intervention Program

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7 January 2021

Reduction of stroke events with pravastatin: the Prospective Pravastatin Pooling (PPP) Project

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7 January 2021

Integrin-dependent homotypic adhesion of neutrophils. Arachidonic acid activates Raf-1/Mek/Erk via a 5-lipoxygenase- dependent pathway.

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7 January 2021

The inhibition of microsomal triglyceride transfer protein activity in rat hepatoma cells promotes proteasomal and nonproteasomal degradation of apoprotein b100.

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7 January 2021

Early and Sustained Survival Benefit Associated With Statin Therapy at the Time of Percutaneous Coronary Intervention

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7 January 2021

Association between enhanced soluble CD40L and prothrombotic state in hypercholesterolemia: effects of statin therapy

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7 January 2021

Inhibitors of prenylation of Ras and other G-proteins and their application as therapeutics

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7 January 2021

Pravastatin treatment increases collagen content and decreases lipid content, inflammation, metalloproteinases, and cell death in human carotid plaques: implications for plaque stabilization

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7 January 2021

Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content

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7 January 2021

Cell and molecular biology of the assembly and secretion of apolipoprotein B-containing lipoproteins by the liver

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7 January 2021

Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins

1 reference

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7 January 2021

B-mode ultrasound assessment of pravastatin treatment effect on carotid and femoral artery walls and its correlations with coronary arteriographic findings: a report of the Regression Growth Evaluation Statin Study (REGRESS)

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7 January 2021

Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors

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7 January 2021

Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study

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7 January 2021

Clinical pharmacologic concepts for the rational selection and use of drugs for the management of dyslipidemia

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7 January 2021

A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta

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7 January 2021

Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase

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7 January 2021

Effects of cholesterol and inflammation-sensitive plasma proteins on incidence of myocardial infarction and stroke in men.

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7 January 2021

3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells. Role of geranylgeranylation and Rho proteins

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7 January 2021

Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways

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7 January 2021

Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)

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7 January 2021

Pleiotropic effects of statins.

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7 January 2021

Are we mortgaging the medical profession?

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7 January 2021

3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase and Isoprenylation Inhibitors Induce Apoptosis of Vascular Smooth Muscle Cells in Culture

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7 January 2021

Rho GTPases and the actin cytoskeleton

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7 January 2021

Withdrawal of statins increases event rates in patients with acute coronary syndromes

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7 January 2021

The lipoprotein and coronary atherosclerosis study (LCAS): lipid and metabolic factors related to atheroma and clinical events

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7 January 2021

The role of prenylation in G-protein assembly and function

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7 January 2021

Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins).

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7 January 2021

Statins and monocytes

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7 January 2021

A comparison of simvastatin and atorvastatin up to maximal recommended doses in a large multicenter randomized clinical trial

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7 January 2021

Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: reduction of MRNA levels for interleukin-1beta, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor alpha (PPARalpha) in pri

1 reference

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7 January 2021

Inhibition of Rho/Rho-kinase signaling downregulates plasminogen activator inhibitor-1 synthesis in cultured human monocytes

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7 January 2021

Structural mechanism for statin inhibition of HMG-CoA reductase

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7 January 2021

Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis

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7 January 2021

Statins and peripheral neuropathy

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7 January 2021

Niacin accelerates intracellular ApoB degradation by inhibiting triacylglycerol synthesis in human hepatoblastoma (HepG2) cells

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7 January 2021

Pretreatment with simvastatin attenuates myocardial dysfunction after ischemia and chronic reperfusion

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7 January 2021

Atorvastatin attenuates remnant lipoprotein-induced monocyte adhesion to vascular endothelium under flow conditions

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7 January 2021

Statins and C-reactive protein

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7 January 2021

Effect of pravastatin on outcomes after cardiac transplantation.

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7 January 2021

Hydroxymethylglutaryl coenzyme A reductase inhibitors modify the inflammatory response of human macrophages and endothelial cells infected with Chlamydia pneumoniae

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7 January 2021

Central role of peroxisomes in isoprenoid biosynthesis

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7 January 2021

Cell compartmentalization of cholesterol biosynthesis

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7 January 2021

The Role of a Common Variant of the Cholesteryl Ester Transfer Protein Gene in the Progression of Coronary Atherosclerosis

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7 January 2021

The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals

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7 January 2021

Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase

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7 January 2021

Inhibition of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Blocks Hypoxia-mediated Down-regulation of Endothelial Nitric Oxide Synthase

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7 January 2021

Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice

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7 January 2021

Statins as potent antiinflammatory drugs

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7 January 2021

Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts

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7 January 2021

Treatment with atorvastatin improves small artery compliance in patients with severe hypercholesterolemia

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7 January 2021

Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice

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7 January 2021

Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s)

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7 January 2021

Dynamic regulation of LFA-1 activation and neutrophil arrest on intercellular adhesion molecule 1 (ICAM-1) in shear flow

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7 January 2021

Statin-induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-I

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7 January 2021

Inhibitory effect of Lovastatin on spontaneous metastases derived from a rat lymphoma

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7 January 2021

Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor

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7 January 2021

MRC/BHF Heart Protection Study of cholesterol-lowering therapy and of antioxidant vitamin supplementation in a wide range of patients at increased risk of coronary heart disease death: early safety and efficacy experience

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7 January 2021

MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial

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7 January 2021

Statins as immunomodulators: comparison with interferon-beta 1b in MS.

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7 January 2021

Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men

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7 January 2021

Inhibitory effect of fluvastatin, an HMG-CoA reductase inhibitor, on the expression of adhesion molecules on human monocyte cell line

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7 January 2021

Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month

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7 January 2021

Increased number of high sensitive platelets in hypercholesterolemia, cardiovascular diseases, and after incubation with cholesterol

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7 January 2021

Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages

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7 January 2021

New evidence for beneficial effects of statins unrelated to lipid lowering

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7 January 2021

Blood pressure reduction with HMG-CoA reductase inhibitors in renal transplant recipients

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7 January 2021

Simvastatin inhibits leukocyte-endothelial cell interactions and protects against inflammatory processes in normocholesterolemic rats

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7 January 2021

Simvastatin inhibits inflammatory properties of Staphylococcus aureus alpha-toxin

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7 January 2021

Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization

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7 January 2021

Effects of fibrates on metabolism of statins in human hepatocytes

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7 January 2021

High-sensitivity C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease

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7 January 2021

Inflammatory biomarkers, statins, and the risk of stroke: cracking a clinical conundrum

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7 January 2021

Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) Investigators

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7 January 2021

Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men.

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7 January 2021

Elevation of tumor necrosis factor-alpha and increased risk of recurrent coronary events after myocardial infarction

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7 January 2021

Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease

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7 January 2021

Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia

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7 January 2021

Inhibition of monocyte chemotactic protein-1 synthesis by statins

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7 January 2021

Statin use in acute coronary syndromes: cellular mechanisms and clinical evidence

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7 January 2021

Antiatherothrombotic properties of statins: implications for cardiovascular event reduction

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7 January 2021

Clinical outcomes in statin treatment trials: a meta-analysis

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7 January 2021

Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study

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7 January 2021

Diurnal variation of HMG-CoA reductase activity in rat liver peroxisomes

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7 January 2021

The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators

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7 January 2021

Coronary heart disease in patients with low LDL-cholesterol: benefit of pravastatin in diabetics and enhanced role for HDL-cholesterol and triglycerides as risk factors

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7 January 2021

Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial

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7 January 2021

Effect of simvastatin on monocyte adhesion molecule expression in patients with hypercholesterolemia

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7 January 2021

Fluvastatin for prevention of cardiac events following successful first percutaneous coronary intervention: a randomized controlled trial

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7 January 2021

Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group

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7 January 2021

Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial

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7 January 2021

Simvastatin has anti-inflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering

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7 January 2021

Additional reduction in blood pressure after cholesterol-lowering treatment by statins (lovastatin or pravastatin) in hypercholesterolemic patients using angiotensin-converting enzyme inhibitors (enalapril or lisinopril)

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7 January 2021

A new HMG-CoA reductase inhibitor, rosuvastatin, exerts anti-inflammatory effects on the microvascular endothelium: the role of mevalonic acid

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7 January 2021

Immunomodulation of experimental autoimmune encephalomyelitis in the Lewis rats by Lovastatin

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7 January 2021

Comparison of statins in hypertriglyceridemia

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7 January 2021

Statins reduce inflammation in atheroma of nonhuman primates independent of effects on serum cholesterol

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7 January 2021

Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors

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7 January 2021

ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: a randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness

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7 January 2021

Role of the mevalonate pathway of isoprenoid synthesis in IL-8 generation by activated monocytic cells.

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7 January 2021

Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels

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7 January 2021

The effect of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts

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7 January 2021

The effects of hydroxy-methyl-glutaryl co-enzyme A reductase inhibitors on platelet thrombus formation

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7 January 2021

Pravastatin, an HMG-CoA reductase inhibitor, is transported by rat organic anion transporting polypeptide, oatp2.

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7 January 2021

Effects of pravastatin in 3260 patients with unstable angina: results from the LIPID study

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7 January 2021

Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease

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7 January 2021

FXR, a bile acid receptor and biological sensor

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7 January 2021

Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V, and factor XIII and by enhancing factor Va inactivation

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7 January 2021

Avidity regulation of integrins: the driving force in leukocyte adhesion

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7 January 2021

The evolving role of statins in the management of atherosclerosis

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7 January 2021

Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis

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7 January 2021

Lipid metabolism in peroxisomes in relation to human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900055-X

7 January 2021

HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900055-X

7 January 2021

HMG-CoA Reductase Inhibitors Decrease CD11b Expression and CD11b-Dependent Adhesion of Monocytes to Endothelium and Reduce Increased Adhesiveness of Monocytes Isolated From Patients With Hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900055-X

7 January 2021

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900055-X

7 January 2021

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900055-X

7 January 2021

Dose-response effects of atorvastatin and simvastatin on high-density lipoprotein cholesterol in hypercholesterolaemic patients: a review of five comparative studies

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900055-X

7 January 2021

Effect of atorvastatin on plasma fibrinogen

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900055-X

7 January 2021

High-density lipoprotein cholesterol and triglyceride response with simvastatin versus atorvastatin in familial hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900055-X

7 January 2021

Statin-fibrate combination: therapy for hyperlipidemia: a review

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2803%2900055-X

7 January 2021