The present view of the mechanism of protein folding (Q35141764)

6 August 2017

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title

The present view of the mechanism of protein folding (English)

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6 August 2017

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Alan Fersht

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6 August 2017

Valerie Daggett

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6 August 2017

publication date

1 June 2003

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Nature Reviews Molecular Cell Biology

6 August 2017

published in

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

497-502

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6 August 2017

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Protein folding and unfolding at atomic resolution

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Towards an understanding of amyloidogenesis

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Characterization of the transition state of protein unfolding by use of molecular dynamics: chymotrypsin inhibitor 2

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"New View" of Protein Folding Reconciled with the Old Through Multiple Unfolding Simulations

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Increasing temperature accelerates protein unfolding without changing the pathway of unfolding

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The molecular basis for the chemical denaturation of proteins by urea

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Protein folding from a highly disordered denatured state: the folding pathway of chymotrypsin inhibitor 2 at atomic resolution

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Towards a complete description of the structural and dynamic properties of the denatured state of barnase and the role of residual structure in folding

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Characterization of residual structure in the thermally denatured state of barnase by simulation and experiment: Description of the folding pathway

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Molecular dynamics simulation of the unfolding of barnase: characterization of the major intermediate 1 1Edited by A. R. Fersht

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The complete folding pathway of a protein from nanoseconds to microseconds

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Simulations of the structural and dynamical properties of denatured proteins: the “molten coil” state of bovine pancreatic trypsin inhibitor

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High populations of non-native structures in the denatured state are compatible with the formation of the native folded state

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Effects of topology and excluded volume on protein denatured state conformational properties

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Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding

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Evidence for sequential barriers and obligatory intermediates in apparent two-state protein folding

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Structure of the transition state for folding of a protein derived from experiment and simulation

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Determination of a transition state at atomic resolution from protein engineering data

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Self-consistent determination of the transition state for protein folding: application to a fibronectin type III domain

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How the folding rate constant of simple, single-domain proteins depends on the number of native contacts

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Transition-state structure as a unifying basis in protein-folding mechanisms: contact order, chain topology, stability, and the extended nucleus mechanism

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Long-range order in the src SH3 folding transition state

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NMR and SAXS characterization of the denatured state of the chemotactic protein CheY: implications for protein folding initiation

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Comparison of the folding processes of T. thermophilus and E. coli ribonucleases H.

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Early kinetic intermediate in the folding of acyl-CoA binding protein detected by fluorescence labeling and ultrarapid mixing

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Pathways to a protein folding intermediate observed in a 1-microsecond simulation in aqueous solution

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Absolute comparison of simulated and experimental protein-folding dynamics

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On the simulation of protein folding by short time scale molecular dynamics and distributed computing

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Mechanical and chemical unfolding of a single protein: a comparison

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The key event in force-induced unfolding of Titin's immunoglobulin domains

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Unfolding proteins by external forces and temperature: the importance of topology and energetics

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Mapping the folding pathway of an immunoglobulin domain: structural detail from Phi value analysis and movement of the transition state

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The effect of core destabilization on the mechanical resistance of I27.

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Mechanical unfolding of a titin Ig domain: structure of unfolding intermediate revealed by combining AFM, molecular dynamics simulations, NMR and protein engineering

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Direct observation of better hydration at the N terminus of an alpha-helix with glycine rather than alanine as the N-cap residue

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Determination of the three-dimensional solution structure of barnase using nuclear magnetic resonance spectroscopy

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Structural studies of the engrailed homeodomain

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31 March 2020

Identifiers

DOI

10.1038/NRM1126

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6 August 2017

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