Transcriptional coactivator PC4 stimulates promoter escape and facilitates transcriptional synergy by GAL4-VP16 (Q35127128)

6 August 2017

title

Transcriptional coactivator PC4 stimulates promoter escape and facilitates transcriptional synergy by GAL4-VP16 (English)

1 reference

6 August 2017

Aya Fukuda

1 reference

6 August 2017

Tomoyoshi Nakadai

1 reference

6 August 2017

Miho Shimada

1 reference

6 August 2017

Tohru Tsukui

1 reference

6 August 2017

Masahito Matsumoto

1 reference

6 August 2017

Yasuhisa Nogi

1 reference

6 August 2017

Michael Meisterernst

1 reference

6 August 2017

Koji Hisatake

1 reference

6 August 2017

language of work or name

English

0 references

publication date

1 July 2004

1 reference

Molecular and Cellular Biology

6 August 2017

published in

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6 August 2017

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6 August 2017

1 reference

6 August 2017

page(s)

6525-6535

1 reference

Alleviation of PC4-mediated transcriptional repression by the ERCC3 helicase activity of general transcription factor TFIIH

6 August 2017

cites work

1 reference

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Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation

28 July 2018

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Structure, function, and activator-induced conformations of the CRSP coactivator

28 July 2018

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The regulatory role for the ERCC3 helicase of general transcription factor TFIIH during promoter escape in transcriptional activation

28 July 2018

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The N-terminal regions of estrogen receptor alpha and beta are unstructured in vitro and show different TBP binding properties

28 July 2018

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Transcriptional coactivator complexes

28 July 2018

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The TRAP/SMCC/Mediator complex and thyroid hormone receptor function

28 July 2018

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Orchestrated response: a symphony of transcription factors for gene control

28 July 2018

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Mediator of Transcriptional Regulation

28 July 2018

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Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells

28 July 2018

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Mechanism of ATP-dependent promoter melting by transcription factor IIH

28 July 2018

1 reference

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Intrinsic structural disorder of the C-terminal activation domain from the bZIP transcription factor Fos

28 July 2018

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The many HATs of transcription coactivators

28 July 2018

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Activation of RNA polymerase II transcription

28 July 2018

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Role of general and gene-specific cofactors in the regulation of eukaryotic transcription

28 July 2018

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Coactivator and corepressor complexes in nuclear receptor function

28 July 2018

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An activator binding module of yeast RNA polymerase II holoenzyme

28 July 2018

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Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation

28 July 2018

1 reference

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Interaction of PC4 with melted DNA inhibits transcription

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Promoter-proximal stalling results from the inability to recruit transcription factor IIH to the transcription complex and is a regulated event

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

TAFII-independent activation mediated by human TBP in the presence of the positive cofactor PC4

28 July 2018

1 reference

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Transcription activation via enhanced preinitiation complex assembly in a human cell-free system lacking TAFIIs

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

DA-complex assembly activity required for VP16C transcriptional activation

28 July 2018

1 reference

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High-affinity DNA binding by the C-terminal domain of the transcriptional coactivator PC4 requires simultaneous interaction with two opposing unpaired strands and results in helix destabilization.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation

28 July 2018

1 reference

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C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Requirement for Transcription Factor IIA (TFIIA)-TFIID Recruitment by an Activator Depends on Promoter Structure and Template Competition

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Transcriptional activation by recruitment

28 July 2018

1 reference

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Topoisomerase I enhances TFIID-TFIIA complex assembly during activation of transcription

28 July 2018

1 reference

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Assembly of the isomerized TFIIA--TFIID--TATA ternary complex is necessary and sufficient for gene activation

28 July 2018

1 reference

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Distinct activated and non-activated RNA polymerase II complexes in yeast

28 July 2018

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The human general co-factors

28 July 2018

1 reference

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TAFs mediate transcriptional activation and promoter selectivity

28 July 2018

1 reference

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The role of general initiation factors in transcription by RNA polymerase II

28 July 2018

1 reference

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Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH

28 July 2018

1 reference

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TBP-associated factors are not generally required for transcriptional activation in yeast

28 July 2018

1 reference

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Transcription-positive cofactor 4 forms complexes with HSSB (RPA) on single-stranded DNA and influences HSSB-dependent enzymatic synthesis of simian virus 40 DNA.

28 July 2018

1 reference

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A yeast transcriptional stimulatory protein similar to human PC4.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

pX, the HBV-encoded coactivator, interacts with components of the transcription machinery and stimulates transcription in a TAF-independent manner

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Critical amino acids in the transcriptional activation domain of the herpesvirus protein VP16 are solvent-exposed in highly mobile protein segments. An intrinsic fluorescence study.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

The role of activators in assembly of RNA polymerase II transcription complexes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Phosphorylation negatively regulates the function of coactivator PC4

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Activation of the TFIID-TFIIA complex with HMG-2

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Promoter-proximal pausing of RNA polymerase II defines a general rate-limiting step after transcription initiation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

A class of activation domains interacts directly with TFIIA and stimulates TFIIA-TFIID-promoter complex assembly

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

How eukaryotic transcriptional activators work

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

How different eukaryotic transcriptional activators can cooperate promiscuously.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

A mechanism for synergistic activation of a mammalian gene by GAL4 derivatives.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Activation of class II gene transcription by regulatory factors is potentiated by a novel activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Polymerase II promoter activation: closed complex formation and ATP-driven start site opening

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Reconstitution of recombinant TFIIH that can mediate activator-dependent transcription

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Transcription activation in cells lacking TAFIIS.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Transcriptional activation domain of the herpesvirus protein VP16 becomes conformationally constrained upon interaction with basal transcription factors.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Transcriptional elongation by RNA polymerase II is stimulated by transactivators.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

A general mechanism for transcriptional synergy by eukaryotic activators

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

Local Structural Elements in the Mostly Unstructured Transcriptional Activation Domain of Human p53

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

GAL4-VP16 stimulates two RNA polymerase II promoters primarily at the preinitiation complex assembly step

8 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=434263

A transcription reinitiation intermediate that is stabilized by activator

8 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15226451

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mechanism of action of an acidic transcriptional activator in vitro

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15226451

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structural and functional analysis of the NF-kappa B p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15226451

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.24.14.6525-6535.2004

1 reference

6 August 2017

1 reference

6 August 2017

1 reference