Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function (Q35115023)

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English	Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 August 2017

Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function (English)

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PubMed publication ID

6 August 2017

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bioavailability

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based on heuristic

inferred from title

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10 June 2020

Michiel Adreanus van de Sande

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10 June 2020

Geesje M Dallinga-Thie

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10 June 2020

John J. P. Kastelein

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J J P Kastelein

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10 June 2020

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H L Mooij

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10 June 2020

S J Bernelot Moens

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10 June 2020

D Xu

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10 June 2020

S D Udayappan

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10 June 2020

A G Tsai

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10 June 2020

E de Groot

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10 June 2020

M Intaglietta

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10 June 2020

J D Esko

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10 June 2020

E S Stroes

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10 June 2020

M Nieuwdorp

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10 June 2020

publication date

2 December 2014

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6 August 2017

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

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10 June 2020

3

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10 June 2020

6

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10 June 2020

e001274

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25468659%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Coordinated endothelial nitric oxide synthase activation by translocation and phosphorylation determines flow-induced nitric oxide production in resistance vessels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

Podocyte-specific deletion of NDST1, a key enzyme in the sulfation of heparan sulfate glycosaminoglycans, leads to abnormalities in podocyte organization in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

Fluid shear stress induces the clustering of heparan sulfate via mobility of glypican-1 in lipid rafts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

Hemodynamic shear stress characteristic of atherosclerosis-resistant regions promotes glycocalyx formation in cultured endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

The structural stability of the endothelial glycocalyx after enzymatic removal of glycosaminoglycans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

The assessment of endothelial function: from research into clinical practice

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9 July 2018

Heparanase is essential for the development of diabetic nephropathy in mice.

1 reference

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9 July 2018

Heparan sulfate proteoglycan mediates shear stress-induced endothelial gene expression in mouse embryonic stem cell-derived endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

Role of heparanase on hepatic uptake of intestinal derived lipoprotein and fatty streak formation in mice

1 reference

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9 July 2018

Endothelial surface layer degradation by chronic hyaluronidase infusion induces proteinuria in apolipoprotein E-deficient mice

1 reference

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9 July 2018

Cardiovascular consequences when nitric oxide and lipid signaling converge

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

Endothelial glycocalyx as potential diagnostic and therapeutic target in cardiovascular disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

The endothelial glycocalyx: a mechano-sensor and -transducer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

Heparan sulphate proteoglycans fine-tune mammalian physiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

Heparan sulfate: lessons from knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

Molecular diversity of heparan sulfate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

Mutations in the EXT1 and EXT2 genes in hereditary multiple exostoses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

Identification of distinct luminal domains for macromolecules, erythrocytes, and leukocytes within mammalian capillaries

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9 July 2018

The natural history of hereditary multiple exostoses

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9 July 2018

Albuminuria reflects widespread vascular damage. The Steno hypothesis.

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9 July 2018

Calmodulin is a subunit of nitric oxide synthase from macrophages

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338717

9 July 2018

UK health performance: findings of the Global Burden of Disease Study 2010.

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27 September 2018

Pain, physical and social functioning, and quality of life in individuals with multiple hereditary exostoses in The Netherlands: a national cohort study

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27 September 2018

Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones

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27 September 2018

Vascular smooth muscle cell glycocalyx modulates shear-induced proliferation, migration, and NO production responses

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27 September 2018

Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability

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27 September 2018

Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo.

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27 September 2018

Heparan Sulfate Proteoglycan Is a Mechanosensor on Endothelial Cells

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27 September 2018

Glycosaminoglycans in the blood of hereditary multiple exostoses patients: Half reduction of heparan sulfate to chondroitin sulfate ratio and the possible diagnostic application

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12 December 2020

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inferred from PubMed ID database lookup

Heparan sulfate abnormalities in exostosis growth plates

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https://pubmed.ncbi.nlm.nih.gov/25468659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of hyaluronic acid glycosaminoglycans in shear-induced endothelium-derived nitric oxide release

1 reference

https://pubmed.ncbi.nlm.nih.gov/25468659

12 December 2020

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inferred from PubMed ID database lookup

Microvascular measurements by video image shearing and splitting

1 reference

https://pubmed.ncbi.nlm.nih.gov/25468659

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium-Dependent Inhibition of Constitutive Nitric Oxide Synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/25468659

12 December 2020

based on heuristic

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Role of endothelial nitric oxide in microvascular oxygen delivery and consumption

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/JAHA.114.001274

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25468659%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25468659%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25468659%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

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